Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0028 | 0.0000010538 | 0.0000010538 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0028 | 0.0000010538 | 0.0000010538 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0028 | 0.0000010538 | 0.0000010538 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | transient receptor potential channel | 0.0028 | 0.0000010538 | 0.0000010538 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 1 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0028 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0028 | 0.0000010538 | 0.0000010538 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0000010538 | 0.0000010538 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0028 | 0.0000010538 | 0.0000010538 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0028 | 0.0000010538 | 0.0000010538 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0028 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 1 | 1 |
Leishmania major | hypothetical protein, unknown function | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0000010538 | 0.0000010538 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0028 | 0.0000010538 | 0.0000010538 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0028 | 0 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0028 | 0.0000010538 | 0.0000010538 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0000010538 | 0.0000010538 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 610 nM | Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine chloride as substrate preincubated for 15 mins before substrate addition by Ellman's method | ChEMBL. | 22444876 |
IC50 (binding) | = 1440 nM | Inhibition of electric eel acetylcholinesterase using acetylcholine chloride as substrate preincubated for 15 mins before substrate addition by Ellman's method | ChEMBL. | 22444876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.