Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0279 | 0.0279 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0028 | 0.0279 | 0.0279 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0279 | 0.0279 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0279 | 0.0279 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0028 | 0.0279 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0279 | 0.0279 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0279 | 0.0279 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0279 | 0.0279 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0279 | 0.0279 |
Onchocerca volvulus | 0.0028 | 0.0279 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0028 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0279 | 0.0279 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0279 | 0.0279 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0028 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0279 | 0.0279 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0028 | 0.0279 | 0.0279 |
Schistosoma mansoni | acetylcholinesterase | 0.0028 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0028 | 0.0279 | 0.0279 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0028 | 0.0279 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0028 | 0.0279 | 0.0279 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0028 | 0.0279 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0279 | 0.0279 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0279 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0279 | 0.0279 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0028 | 0.0279 | 0.0279 |
Onchocerca volvulus | 0.0028 | 0.0279 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0028 | 0.0279 | 0.0279 |
Onchocerca volvulus | 0.0028 | 0.0279 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0279 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0279 | 0.0279 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0028 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0279 | 0.0279 |
Echinococcus multilocularis | neuroligin | 0.0028 | 0.0279 | 0.0279 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.0279 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0028 | 0.0279 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0028 | 0.0279 | 0.0279 |
Onchocerca volvulus | 0.0028 | 0.0279 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1510 nM | Inhibition of electric eel acetylcholinesterase using acetylcholine chloride as substrate preincubated for 15 mins before substrate addition by Ellman's method | ChEMBL. | 22444876 |
IC50 (binding) | = 6750 nM | Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine chloride as substrate preincubated for 15 mins before substrate addition by Ellman's method | ChEMBL. | 22444876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.