Detailed information for compound 1636110

Basic information

Technical information
  • TDR Targets ID: 1636110
  • Name: 6-phenyl-1,2,4-triazine-3,5-diamine
  • MW: 187.201 | Formula: C9H9N5
  • H donors: 2 H acceptors: 3 LogP: 0.16 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nnc(c(n1)N)c1ccccc1
  • InChi: 1S/C9H9N5/c10-8-7(13-14-9(11)12-8)6-4-2-1-3-5-6/h1-5H,(H4,10,11,12,14)
  • InChiKey: IGICDOGCTIXJCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3-amino-6-phenyl-1,2,4-triazin-5-yl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens casein kinase 1, alpha 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei gambiense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi casein kinase 1, delta Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma brucei casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Cryptosporidium hominis casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Toxoplasma gondii casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma congolense casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium berghei casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania braziliensis casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Theileria parva casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania infantum casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Entamoeba histolytica casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Cryptosporidium parvum casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania mexicana casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium yoelii casein kinase i Get druggable targets OG5_126780 All targets in OG5_126780
Babesia bovis casein kinase I, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, delta isoform, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium vivax casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Brugia malayi casein kinase I Get druggable targets OG5_126780 All targets in OG5_126780
Giardia lamblia Kinase, CK1 Casein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum ko:K02218 casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum Casein kinase I isoform delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium falciparum casein kinase 1 Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma congolense casein kinase I, isoform 2 Get druggable targets OG5_126780 All targets in OG5_126780
Trypanosoma cruzi casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Trichomonas vaginalis CK1 family protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus multilocularis casein kinase I delta Get druggable targets OG5_126780 All targets in OG5_126780
Plasmodium knowlesi casein kinase 1, putative Get druggable targets OG5_126780 All targets in OG5_126780
Candida albicans Casein kinase I: DNA repair, meiosis Get druggable targets OG5_126780 All targets in OG5_126780
Echinococcus granulosus casein kinase I alpha Get druggable targets OG5_126780 All targets in OG5_126780
Onchocerca volvulus Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126780 All targets in OG5_126780
Neospora caninum AFL091Wp, related Get druggable targets OG5_126780 All targets in OG5_126780
Schistosoma japonicum ko:K08959 casein kinase 1, delta, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania major casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Leishmania donovani casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126780 All targets in OG5_126780
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Protein kinase domain containing protein casein kinase 1, alpha 1 365 aa 307 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi acetyl-CoA carboxylase 0.0254 0.5408 1
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0156 0.2536 0.5
Entamoeba histolytica acetyl-coA carboxylase, putative 0.007 0 0.5
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0396 0.9578 0.5
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0156 0.2536 0.5
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0156 0.2536 0.5
Trypanosoma brucei acetyl-CoA carboxylase 0.0411 1 1
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0156 0.2536 0.1741
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.007 0 0.5
Leishmania major acetyl-CoA carboxylase, putative 0.0411 1 1
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0411 1 1
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0297 0.6669 0.5
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0411 1 1
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0156 0.2536 0.5
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0156 0.2536 0.5
Mycobacterium ulcerans pyruvate carboxylase 0.0156 0.2536 0.5
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0156 0.2536 0.5
Brugia malayi Carboxyl transferase domain containing protein 0.0396 0.9578 0.5
Chlamydia trachomatis biotin carboxylase 0.0142 0.2114 0.5
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0297 0.6669 0.5
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0411 1 1
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0156 0.2536 0.1741
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0156 0.2536 0.5
Schistosoma mansoni acetyl-CoA carboxylase 0.0411 1 1

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 4.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference
Ki (functional) = 4.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1A1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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