Detailed information for compound 163666

Basic information

Technical information
  • TDR Targets ID: 163666
  • Name: 5-phenyl-N-pyrazin-2-yl-1,3-thiazol-2-amine
  • MW: 254.31 | Formula: C13H10N4S
  • H donors: 1 H acceptors: 3 LogP: 2.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)c1cnc(s1)Nc1cnccn1
  • InChi: 1S/C13H10N4S/c1-2-4-10(5-3-1)11-8-16-13(18-11)17-12-9-14-6-7-15-12/h1-9H,(H,15,16,17)
  • InChiKey: DCRDZICLFLDBFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-phenyl-N-pyrazin-2-yl-thiazol-2-amine
  • 5-phenyl-N-(2-pyrazinyl)-2-thiazolamine
  • (5-phenylthiazol-2-yl)-pyrazin-2-yl-amine
  • N-(5-phenyl-1,3-thiazol-2-yl)pyrazin-2-amine
  • N-(5-phenylthiazol-2-yl)pyrazin-2-amine
  • N-(5-phenyl-2-thiazolyl)-2-pyrazinamine
  • aminothiazole 4

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin D (A01 family) 0.0176 0.1152 0.1152
Plasmodium vivax subtilisin-like protease 2, putative 0.0061 0.0336 0.5737
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0868 0.604 1
Plasmodium vivax plasmepsin V, putative 0.0045 0.0225 0.2585
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0225 0.0225
Trypanosoma brucei subtilisin peptidase 0.0061 0.0336 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0225 0.0225
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Giardia lamblia Furin precursor putative serine protease 0.0276 0.1857 0.508
Echinococcus granulosus neuroendocrine convertase 2 0.0897 0.6249 0.6249
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0061 0.0336 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0032 0.0134 0.2758
Plasmodium vivax subtilisin-like serine protease, putative 0.0061 0.0336 0.5737
Onchocerca volvulus 0.0061 0.0336 0.0988
Schistosoma mansoni amine oxidase 0.0032 0.0134 0.0134
Brugia malayi Subtilase family protein 0.0061 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0134
Plasmodium vivax plasmepsin IV, putative 0.0082 0.0486 1
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0336 0.0556
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0276 0.1857 0.3075
Plasmodium vivax aspartyl proteinase, putative 0.0082 0.0486 1
Toxoplasma gondii subtilisin SUB4 0.0061 0.0336 0.6913
Echinococcus granulosus Furin 1 0.0337 0.2289 0.2289
Loa Loa (eye worm) endoprotease bli-4 0.1428 1 1
Toxoplasma gondii subtilisin SUB11 0.0061 0.0336 0.6913
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.1196 0.1196
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0061 0.0336 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0868 0.604 0.604
Schistosoma mansoni cathepsin D (A01 family) 0.0176 0.1152 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Plasmodium falciparum plasmepsin I 0.0082 0.0486 1
Plasmodium falciparum plasmepsin IV 0.0082 0.0486 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0082 0.0486 0.0604
Schistosoma mansoni Lysine-specific histone demethylase 1 0.016 0.1034 0.1034
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0336 0.0556
Brugia malayi hypothetical protein 0.0045 0.0225 0.0225
Brugia malayi Pepsin A precursor 0.0045 0.0225 0.0225
Toxoplasma gondii aspartyl protease 0.0045 0.0225 0.463
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0045 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0134
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0061 0.0336 0.0336
Toxoplasma gondii subtilisin SUB12 0.0061 0.0336 0.6913
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Toxoplasma gondii subtilisin SUB8 0.0061 0.0336 0.6913
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Schistosoma mansoni site-1 peptidase (S08 family) 0.0061 0.0336 0.0336
Schistosoma mansoni memapsin-2 (A01 family) 0.0856 0.5956 0.5956
Onchocerca volvulus CoRest homolog 0.0204 0.1347 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0225 0.0225
Giardia lamblia High cysteine membrane protein Group 2 0.053 0.3656 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Loa Loa (eye worm) hypothetical protein 0.0045 0.0225 0.0225
Toxoplasma gondii aspartyl protease ASP3 0.0045 0.0225 0.463
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.1111 0.7891
Brugia malayi SWIRM domain containing protein 0.0173 0.113 0.113
Schistosoma mansoni amine oxidase 0.0032 0.0134 0.0134
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1428 1 1
Echinococcus granulosus roundabout 2 0.0018 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0868 0.604 0.7506
Echinococcus granulosus membrane bound transcription factor site 1 0.0061 0.0336 0.0336
Echinococcus granulosus lysine specific histone demethylase 1A 0.016 0.1034 0.1034
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Loa Loa (eye worm) hypothetical protein 0.0198 0.1306 0.1306
Schistosoma mansoni cell adhesion molecule 0.0015 0.001 0.001
Plasmodium vivax aspartyl protease, putative 0.0045 0.0225 0.2585
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0061 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.003
Echinococcus multilocularis 0.1151 0.8047 1
Mycobacterium leprae Possible secreted protease 0.0061 0.0336 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Echinococcus multilocularis protoporphyrinogen oxidase 0.0032 0.0134 0.0167
Plasmodium falciparum plasmepsin VIII, putative 0.0045 0.0225 0.2585
Plasmodium falciparum plasmepsin III 0.0045 0.0225 0.2585
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Loa Loa (eye worm) aspartyl protease 6 0.0045 0.0225 0.0225
Brugia malayi hypothetical protein 0.0045 0.0225 0.0225
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0061 0.0336 1
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0082 0.0486 0.0486
Brugia malayi Eukaryotic aspartyl protease family protein 0.0045 0.0225 0.0225
Toxoplasma gondii subtilisin SUB7 0.0061 0.0336 0.6913
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Chlamydia trachomatis protoporphyrinogen oxidase 0.0032 0.0134 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.016 0.1034 0.1034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0486 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Toxoplasma gondii subtilisin SUB1 0.0061 0.0336 0.6913
Loa Loa (eye worm) hypothetical protein 0.0173 0.113 0.113
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0868 0.604 1
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Leishmania major subtilisin-like serine peptidase 0.0061 0.0336 1
Echinococcus multilocularis membrane bound transcription factor site 1 0.0061 0.0336 0.0417
Plasmodium vivax subtilisin-like protease 1 0.0061 0.0336 0.5737
Plasmodium falciparum plasmepsin IX 0.0045 0.0225 0.2585
Echinococcus multilocularis roundabout 2 0.0018 0.003 0.0037
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0061 0.0336 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0061 0.0336 1
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0061 0.0336 1
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0061 0.0336 0.0336
Onchocerca volvulus 0.0167 0.1083 0.7646
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0337 0.2289 0.3789
Toxoplasma gondii subtilisin SUB10 0.0061 0.0336 0.6913
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0336 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0336 0.0556
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0276 0.1857 0.3075
Entamoeba histolytica hypothetical protein 0.0014 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1428 1 1
Brugia malayi celfurPC protein 0.1151 0.8047 0.8047
Loa Loa (eye worm) hypothetical protein 0.0204 0.1347 0.1347
Toxoplasma gondii subtilisin SUB6 0.0061 0.0336 0.6913
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0061 0.0336 1
Plasmodium falciparum plasmepsin X 0.0045 0.0225 0.2585
Echinococcus multilocularis 0.0032 0.0134 0.0167
Brugia malayi proprotein convertase 2 0.0897 0.6249 0.6249
Schistosoma mansoni site-1 peptidase (S08 family) 0.0061 0.0336 0.0336
Plasmodium falciparum plasmepsin II 0.0082 0.0486 1
Toxoplasma gondii subtilisin SUB5 0.0061 0.0336 0.6913
Echinococcus granulosus furin 0.1428 1 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0045 0.0225 0.0225
Brugia malayi Myb-like DNA-binding domain containing protein 0.0198 0.1306 0.1306
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0337 0.2289 0.3789
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0046 0.023 0.023
Echinococcus multilocularis neuroendocrine convertase 2 0.0897 0.6249 0.7765
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0337 0.2289 0.2289
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0336 0.0556
Toxoplasma gondii histone lysine-specific demethylase 0.0032 0.0134 0.2758
Plasmodium vivax aspartyl protease, putative 0.0045 0.0225 0.2585
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0061 0.0336 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Echinococcus granulosus lysine specific histone demethylase 1A 0.0032 0.0134 0.0134
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0337 0.2289 0.3789
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0082 0.0486 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Loa Loa (eye worm) proprotein convertase 2 0.0337 0.2289 0.2289
Toxoplasma gondii subtilisin SUB9 0.0061 0.0336 0.6913
Echinococcus multilocularis lysine specific histone demethylase 1A 0.016 0.1034 0.1285
Echinococcus granulosus twitchin 0.0014 0.0004 0.0004
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0045 0.0225 0.463
Plasmodium falciparum subtilisin-like protease 1 0.0061 0.0336 0.5737
Plasmodium falciparum subtilisin-like protease 2 0.0061 0.0336 0.5737
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0337 0.2289 0.3789
Loa Loa (eye worm) hypothetical protein 0.0045 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.016 0.1034 0.1034
Trypanosoma cruzi subtilisin peptidase 0.0061 0.0336 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0336 0.0336
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0082 0.0486 0.0804
Echinococcus multilocularis neuroglian 0.0014 0.0004 0.0005
Toxoplasma gondii aspartyl protease ASP1 0.0082 0.0486 1
Echinococcus multilocularis Furin 1 0.0337 0.2289 0.2844
Plasmodium falciparum subtilisin-like protease 3 0.0061 0.0336 0.5737
Loa Loa (eye worm) hypothetical protein 0.0082 0.0486 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0337 0.2289 0.3789
Plasmodium falciparum plasmepsin VI 0.0082 0.0486 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0046 0.023 0.023
Schistosoma mansoni furin-1 (S08 family) 0.0621 0.4296 0.4296
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0225 0.0225
Entamoeba histolytica SWIRM domain protein 0.0014 0 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0225 0.0225
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0061 0.0336 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0045 0.0225 0.0225
Plasmodium falciparum plasmepsin V 0.0045 0.0225 0.2585
Entamoeba histolytica SWIRM domain protein 0.0014 0 0.5
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0061 0.0336 0.0417
Toxoplasma gondii subtilisin SUB2 0.0061 0.0336 0.6913
Trichomonas vaginalis hypothetical protein 0.0276 0.1857 0.3075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0337 0.2289 0.3789
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0061 0.0336 0.0336
Plasmodium vivax aspartyl proteinase, putative 0.0045 0.0225 0.2585
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0061 0.0336 0.5
Schistosoma mansoni nephrin 0.0014 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0276 0.1857 0.1857
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0225 0.0225
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0061 0.0336 0.0336
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0082 0.0486 0.0486
Echinococcus granulosus neuroglian 0.0014 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0225 0.0225
Brugia malayi hypothetical protein 0.0032 0.0134 0.0134
Plasmodium falciparum plasmepsin VII 0.0045 0.0225 0.2585
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0061 0.0336 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Onchocerca volvulus 0.0173 0.113 0.8064
Loa Loa (eye worm) hypothetical protein 0.056 0.3864 0.3864
Brugia malayi neuroendocrine convertase 1 precursor 0.0897 0.6249 0.6249
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.1196 0.1196
Loa Loa (eye worm) subtilase 0.0061 0.0336 0.0336
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0061 0.0336 1
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0061 0.0336 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0276 0.1857 0.3075
Plasmodium vivax aspartyl protease, putative 0.0045 0.0225 0.2585
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0061 0.0336 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1857 0.3075
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0032 0.0134 0.0134

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 23 nM Inhibitory activity towards vascular endothelial growth factor receptor 2 ChEMBL. 15125964
IC50 (binding) = 23 nM Inhibitory activity towards vascular endothelial growth factor receptor 2 ChEMBL. 15125964

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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