Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0292 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0292 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0292 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0154 | 0.1071 | 0.1071 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0292 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0292 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0292 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0292 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0292 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0292 | 1 | 1 |
Onchocerca volvulus | 0.0292 | 1 | 1 | |
Brugia malayi | nuclear receptor RXR | 0.0154 | 0.1071 | 0.1071 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0292 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0292 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0292 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0154 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0292 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0292 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0154 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0154 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0292 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0292 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0292 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0154 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0292 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0154 | 0.1071 | 0.1071 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0292 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0292 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0292 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1071 | 0.1071 |
Brugia malayi | nuclear receptor NHR-88 | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0292 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0292 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0292 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0292 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0154 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0292 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0292 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0292 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0292 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0292 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0292 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0154 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0292 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0292 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0292 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0292 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0292 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0154 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0292 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0292 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Minimum inhibitory concentration towards T. mentagraphytes | ChEMBL. | 15125956 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration towards C. albicans | ChEMBL. | 15125956 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration towards C. neoformans | ChEMBL. | 15125956 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration towards A. fumigatus | ChEMBL. | 15125956 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration towards M. cannis | ChEMBL. | 15125956 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration towards C. albicans | ChEMBL. | 15125956 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration towards C. neoformans | ChEMBL. | 15125956 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.