Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase | 0.3885 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3885 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3885 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.3885 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.3885 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3885 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3885 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.3885 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3885 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.3885 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.3885 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.3885 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.3885 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3885 | 0.5 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.3885 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.3885 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.3885 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.3885 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3885 | 0.5 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.3885 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 47 uM | Inhibition of urokinase-type plasminogen activator using Glt-Gly-Arg-AMC as substrate by spectrofluorometry | ChEMBL. | 22366654 |
IC50 (binding) | > 250 uM | Inhibition of tPA using CH3SO2-D-HHT-Gly-Arg-pNA as substrate by spectrofluorometry | ChEMBL. | 22366654 |
IC50 (binding) | > 250 uM | Inhibition of plasmin using tosyl-Gly-Pro-Lys-pNA as substrate by spectrofluorometry | ChEMBL. | 22366654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.