Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1792 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0884 | 0.4872 | 0.4872 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.0927 | 0.0927 |
Echinococcus multilocularis | geminin | 0.0185 | 0.0927 | 0.0927 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1792 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1792 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.1792 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1792 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1792 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1792 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.0927 | 0.0927 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1792 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1792 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1792 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1792 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1792 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1792 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0185 | 0.0927 | 0.0927 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1792 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1792 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1792 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1792 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.