Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 0.071 uM | Cytotoxicity against human HSC2 cells after 48 hrs | ChEMBL. | 22409967 |
Ratio (binding) | = 50.2 | Inhibition of human MDR1-mediated multidrug resistant in mouse L5178Y cells at 4 uM treated 10 mins before rhodamine 123 challenge measured after 20 mins relative to control | ChEMBL. | 22409967 |
Ratio (binding) | = 73.4 | Inhibition of human MDR1-mediated multidrug resistant in mouse L5178Y cells at 40 uM treated 10 mins before rhodamine 123 challenge measured after 20 mins relative to control | ChEMBL. | 22409967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.