Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 113.85 umol/L | Cytotoxicity against human PBMC after 48 hrs by MTT assay | ChEMBL. | 22401914 |
MIC100 (functional) | Antifungal activity against Candida albicans ATCC 09548 after 24 hrs by broth microdilution method | ChEMBL. | 22401914 | |
MIC50 (functional) | Antifungal activity against Candida albicans ATCC 09548 after 24 hrs by broth microdilution method | ChEMBL. | 22401914 | |
MIC50 (functional) | = 0.044 umol/ml | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method | ChEMBL. | 22401914 |
MIC50 (functional) | = 45.459 umol/ml | Antifungal activity against Cryptococcus neoformans ATCC 90012 after 24 hrs by broth microdilution method | ChEMBL. | 22401914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.