TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 474.408 | Formula: C23H18F4N4O3
H donors: 2 H acceptors: 3 LogP: 3.26 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: NCc1oc(nc1C(=O)NCc1cccc(c1)F)c1ccc(c2c1ccc(n2)C(F)(F)F)OC
InChi: 1S/C23H18F4N4O3/c1-33-16-7-5-15(14-6-8-18(23(25,26)27)30-19(14)16)22-31-20(17(10-28)34-22)21(32)29-11-12-3-2-4-13(24)9-12/h2-9H,10-11,28H2,1H3,(H,29,32)
InChiKey: QSCJWBXGGNYDSG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4B, cAMP-specific	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 11A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	phosphodiesterase 11A	489 aa	471 aa	34.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0033	0.0231	0.0252
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0094	0.0102
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0023	0.0094	0.0102
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0023	0.0094	0.0102
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0179	0.2124	0.2317
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0228	0.0148
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0228	0.9795
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0094	0.0102
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0064	0.0627	0.0684
Schistosoma mansoni	hypothetical protein	0.0353	0.437	0.4768
Brugia malayi	beta-lactamase family protein	0.0033	0.0231	0.0252
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0094	0.0102
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0147	0.0161
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.1071	0.1168
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0332	0.0362
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0023	0.0094	0.0102
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0723	0.9167	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0033	0.0231	1
Giardia lamblia	hypothetical protein	0.0023	0.0094	0.0102
Schistosoma mansoni	hypothetical protein	0.0123	0.1389	0.1515
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0231	0.0252
Plasmodium vivax	hypothetical protein, conserved	0.0023	0.0104	0.0782
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0023	0.0094	0.0102
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0087	0.0931	0.1016
Toxoplasma gondii	hypothetical protein	0.0065	0.0638	0.06
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.1038	0.1133
Entamoeba histolytica	Ran family GTPase	0.0024	0.0115	0.1109
Giardia lamblia	Kinase, CMGC MAPK	0.0723	0.9167	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0723	0.9167	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0123	0.1389	0.1515
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0723	0.9167	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.0231	0.0252
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0231	0.0252
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0231	0.0252
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0332	0.0362
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0479	0.0523
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0094	0.0102
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.1038	0.1133
Brugia malayi	beta-lactamase	0.0033	0.0231	0.0252
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0057	0.0535	0.0535
Echinococcus multilocularis	protein patched	0.0041	0.0332	0.0332
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0094	0.0102
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0033	0.0231	0.0905
Brugia malayi	RNA, U transporter 1	0.0094	0.1018	0.111
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0046	0.0398	0.0434
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0046	0.0398	0.0434
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0094	0.0102
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0023	0.0104	0.4518
Loa Loa (eye worm)	PDE1B protein	0.0023	0.0094	0.0102
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0104	0.0114
Brugia malayi	Latrophilin receptor protein 2	0.0057	0.0535	0.0584
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0121	0.1364	0.1364
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0115	0.0126
Schistosoma mansoni	hypothetical protein	0.0057	0.0535	0.0584
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.0115	0.0126
Schistosoma mansoni	hypothetical protein	0.0153	0.1787	0.195
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0479	0.0523
Schistosoma mansoni	ran	0.0024	0.0115	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0231	0.0252
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.157	0.1713
Mycobacterium tuberculosis	Probable lipase LipD	0.0033	0.0231	0.0905
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0023	0.0094	0.0102
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0121	0.1364	0.1488
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0931	0.1016
Schistosoma mansoni	importin beta-1	0.0033	0.0228	0.0249
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0332	0.0362
Mycobacterium tuberculosis	Probable lipase LipE	0.0033	0.0231	0.0905
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Mycobacterium ulcerans	putative regulatory protein	0.0023	0.0104	0.4518
Schistosoma mansoni	serine/threonine protein kinase	0.0723	0.9167	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0231	0.0905
Trichomonas vaginalis	CMGC family protein kinase	0.0723	0.9167	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1038	0.1133
Leishmania major	GTP-binding protein, putative	0.0024	0.0115	0.0126
Brugia malayi	beta-lactamase family protein	0.0033	0.0231	0.0252
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0723	0.9167	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0398	0.0434
Echinococcus granulosus	snurportin 1	0.0353	0.437	0.4768
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0102
Schistosoma mansoni	hypothetical protein	0.0057	0.0535	0.0584
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0064	0.0627	0.0684
Toxoplasma gondii	hypothetical protein	0.0023	0.0104	0.0012
Toxoplasma gondii	GAF domain-containing protein	0.0023	0.0104	0.0012
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.157	0.157
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.0115	0.0126
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0353	0.437	0.4768
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0147	0.0161
Schistosoma mansoni	hypothetical protein	0.004	0.0312	0.0341
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0023	0.0094	0.0102
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0023	0.0094	0.0094
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0115	0.0126
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0231	0.0905
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0087	0.0931	0.1016
Trypanosoma brucei	protein kinase, putative	0.0723	0.9167	1
Schistosoma mansoni	hypothetical protein	0.004	0.0312	0.0341
Schistosoma mansoni	hypothetical protein	0.004	0.0312	0.0341
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0332	0.0332
Trypanosoma brucei	hypothetical protein, conserved	0.0033	0.0231	0.0252
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0023	0.0094	0.0102
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0231	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0023	0.0094	0.0102
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0023	0.0094	0.0102
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0024	0.0115	0.0126
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1364	0.1488
Schistosoma mansoni	ran	0.0024	0.0115	0.0126
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0723	0.9167	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0121	0.1364	0.1488
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0023	0.0094	0.0102
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0104	0.0114
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0479	0.0479
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0023	0.0094	0.0102
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.1071	0.1168
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.1038	0.1038
Loa Loa (eye worm)	beta-lactamase	0.0033	0.0231	0.0252
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0046	0.0398	0.0434
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0638	0.0696
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.0115	0.1569
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0479	0.0523
Entamoeba histolytica	hypothetical protein	0.0027	0.0147	0.1418
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0638	0.0696
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0023	0.0094	0.0102
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0931	0.1016
Echinococcus multilocularis	GPCR, family 2	0.0057	0.0535	0.0535
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0023	0.0094	0.0094
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0023	0.0094	0.0102
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0087	0.0931	0.1016
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0057	0.0535	0.0584
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0231	0.0252
Brugia malayi	CHE-14 protein	0.0041	0.0332	0.0362
Toxoplasma gondii	hypothetical protein	0.0023	0.0104	0.0012
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0033	0.0231	0.0231
Brugia malayi	Importin beta-1 subunit	0.0033	0.0228	0.0249
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0284	0.3486	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0723	0.9167	0.9167
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.0115	0.0115
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0231	0.0252
Echinococcus multilocularis	snurportin 1	0.0353	0.437	0.437
Trichomonas vaginalis	CMGC family protein kinase	0.0723	0.9167	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0087	0.0931	0.1016
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0024	0.0115	0.0024
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0046	0.0398	0.0434
Mycobacterium leprae	Probable lipase LipE	0.0033	0.0231	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.1071	0.1168
Mycobacterium leprae	conserved hypothetical protein	0.0033	0.0231	1
Trichomonas vaginalis	CMGC family protein kinase	0.0723	0.9167	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0228	0.0249
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0094	0.0102
Mycobacterium ulcerans	lipase LipD	0.0033	0.0231	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0231	0.0252
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0033	0.0231	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0231	0.0252
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0087	0.0931	0.1016
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0231	0.0252
Trichomonas vaginalis	esterase, putative	0.0033	0.0231	0.0252
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0479	0.0523
Brugia malayi	MAP kinase sur-1	0.0723	0.9167	1
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0087	0.0931	0.0931
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0023	0.0094	0.0102
Echinococcus granulosus	geminin	0.0153	0.1787	0.195
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0479	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0179	0.2124	0.2317
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0057	0.0535	0.0584
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.0115	0.0126
Mycobacterium ulcerans	putative regulatory protein	0.0023	0.0104	0.4518
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0094	0.0102
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0212	0.2553	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0479	0.0523
Schistosoma mansoni	hypothetical protein	0.0057	0.0535	0.0584
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0479	0.0523
Giardia lamblia	Hypothetical protein	0.0023	0.0094	0.0102
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0023	0.0094	0.0102
Echinococcus multilocularis	expressed conserved protein	0.009	0.0963	0.0963
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0231	0.0252
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0023	0.0094	0.0102
Schistosoma mansoni	hypothetical protein	0.0057	0.0535	0.0584
Leishmania major	hypothetical protein, conserved	0.0023	0.0094	0.0102
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0023	0.0094	0.0102
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.0931	0.1016
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0046	0.0398	0.0434
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0228	0.0249
Brugia malayi	N-terminal motif family protein	0.0284	0.3486	0.3803
Leishmania major	hypothetical protein, conserved	0.0033	0.0231	0.0252
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0023	0.0104	0.0409
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0024	0.0115	0.0126
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0023	0.0094	0.0102
Echinococcus multilocularis	geminin	0.0153	0.1787	0.1787
Mycobacterium ulcerans	hypothetical protein	0.0033	0.0231	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0057	0.0535	0.0535
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0046	0.0398	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0102
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0023	0.0094	0.0102
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0064	0.0627	0.0684
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0231	0.0252
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0407	0.0407
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0023	0.0094	0.0102
Echinococcus multilocularis	mitogen activated protein kinase	0.0723	0.9167	0.9167
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.0094	0.0102
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0023	0.0104	0.0409
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0023	0.0094	0.0094
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0723	0.9167	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0033	0.0231	0.0252
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0057	0.0535	0.0584
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0023	0.0094	0.0102
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0723	0.9167	1
Plasmodium falciparum	importin beta, putative	0.0033	0.0228	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0057	0.0535	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0535	0.0584
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0179	0.2124	0.2317
Loa Loa (eye worm)	hypothetical protein	0.005	0.0451	0.0492
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0023	0.0094	0.0102
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0023	0.0094	0.0102
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0147	0.0161
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0231	0.0252
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0723	0.9167	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0087	0.0931	0.1016
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0046	0.0398	0.0398
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0332	0.0362
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0023	0.0094	0.0102
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.0094	0.0102
Mycobacterium tuberculosis	Probable esterase LipL	0.0033	0.0231	0.0905
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0033	0.0231	0.0905
Echinococcus granulosus	mitogen activated protein kinase 3	0.0723	0.9167	1
Trichomonas vaginalis	CMGC family protein kinase	0.0723	0.9167	1
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0023	0.0094	0.0102
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.1058	0.1154
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0121	0.1364	0.1488
Schistosoma mansoni	patched 1	0.0041	0.0332	0.0362
Mycobacterium tuberculosis	Probable hydrolase	0.0033	0.0231	0.0905
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0094	0.0102
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0033	0.0231	0.0905
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.0231	0.0252
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0087	0.0931	0.1016
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.0094	0.0102
Toxoplasma gondii	ABC1 family protein	0.0033	0.0231	0.0151
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Echinococcus granulosus	mitogen activated protein kinase	0.0723	0.9167	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.1038	1
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0147	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0284	0.3486	0.3803
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0023	0.0094	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0228	0.0249
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0023	0.0094	0.0102
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0121	0.1364	0.1364
Echinococcus granulosus	GPCR family 2	0.0057	0.0535	0.0584
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0228	0.0249
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.1071	0.1071
Trichomonas vaginalis	ran, putative	0.0024	0.0115	0.0126
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0023	0.0094	0.0102
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0121	0.1364	0.1488
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0479	0.0523
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0179	0.2124	0.2317
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0023	0.0094	0.0094
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0087	0.0931	0.1016
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0023	0.0094	0.0102
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0121	0.1364	0.1401
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0023	0.0094	0.0102
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0147	0.0161
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0723	0.9167	1
Plasmodium falciparum	GAF domain-related protein, putative	0.0023	0.0104	0.0799
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0023	0.0094	0.0102
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0087	0.0931	0.1016
Schistosoma mansoni	hypothetical protein	0.0153	0.1787	0.195
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.0115	0.1601
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1389	0.1515
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0023	0.0094	0.0102
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0046	0.0398	0.0434
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0033	0.0231	0.0252
Leishmania major	hypothetical protein, conserved	0.0023	0.0094	0.0102
Schistosoma mansoni	hypothetical protein	0.004	0.0312	0.0341
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0638	0.0696
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0087	0.0931	0.1016
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0332	0.0362
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0931	0.1016
Mycobacterium ulcerans	beta-lactamase	0.0033	0.0231	1
Echinococcus granulosus	expressed conserved protein	0.009	0.0963	0.1051
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0231	0.0252
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0231	0.0905
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0023	0.0094	0.0102
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0023	0.0094	0.0102

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.8 nM	Inhibition of PDE4B	ChEMBL.	22401864
IC50 (binding)	= 3900 nM	Inhibition of PDE11	ChEMBL.	22401864

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2012212

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1637456