Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | No references |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 uM | Compound was evaluated for inhibitory activity against human Prostaglandin G/H synthase 2 | ChEMBL. | No reference |
IC50 (binding) | = 14 uM | Compound was evaluated for inhibitory activity against human Prostaglandin G/H synthase 2 | ChEMBL. | No reference |
IC50 (binding) | > 1000 uM | Compound was evaluated for inhibitory activity against ovine Prostaglandin G/H synthase 1 | ChEMBL. | No reference |
IC50 (binding) | > 1000 uM | Compound was evaluated for inhibitory activity against ovine Prostaglandin G/H synthase 1 | ChEMBL. | No reference |
Selectivity (binding) | > 71.4 | Selectivity of the compound was evaluated on COX-1 to COX-2 | ChEMBL. | No reference |
Selectivity (binding) | > 71.4 | Selectivity of the compound was evaluated on COX-1 to COX-2 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.