Detailed information for compound 1637592

Basic information

Technical information
  • TDR Targets ID: 1637592
  • Name: 3-(2-methylphenyl)-1-[3-[(2-methylphenyl)carb amoylamino]phenyl]urea
  • MW: 374.436 | Formula: C22H22N4O2
  • H donors: 4 H acceptors: 2 LogP: 3.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1C)Nc1cccc(c1)NC(=O)Nc1ccccc1C
  • InChi: 1S/C22H22N4O2/c1-15-8-3-5-12-19(15)25-21(27)23-17-10-7-11-18(14-17)24-22(28)26-20-13-6-4-9-16(20)2/h3-14H,1-2H3,(H2,23,25,27)(H2,24,26,28)
  • InChiKey: QPRZJIMXMVWCAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(2-methylphenyl)-1-[3-[[[(2-methylphenyl)amino]-oxomethyl]amino]phenyl]urea
  • ZINC00844837
  • 1-o-Tolyl-3-[3-(3-o-tolyl-ureido)-phenyl]-urea
  • BAS 00184691

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Putative ATP-dependent RNA helicase Pl10, putative Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium knowlesi ATP-dependent RNA helicase DBP1, putative Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium berghei ATP-dependent RNA helicase DBP1, putative Get druggable targets OG5_126849 All targets in OG5_126849
Loa Loa (eye worm) ATP-dependent RNA helicase An3 Get druggable targets OG5_126849 All targets in OG5_126849
Leishmania mexicana ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Cryptosporidium parvum Dbp1p, eIF4a-1 family RNA SFII helicase (DEXDC+HELICc) Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma cruzi ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126849 All targets in OG5_126849
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Schistosoma japonicum Putative ATP-dependent RNA helicase Pl10, putative Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma brucei gambiense ATP-dependent DEAD/H RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126849 All targets in OG5_126849
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Candida albicans ATP-dependent RNA helicase of DEAD box family Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus multilocularis atp dependent rna helicase ddxx atp dependent rna helicase an Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma brucei ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Babesia bovis DEAD/DEAH box helicase Get druggable targets OG5_126849 All targets in OG5_126849
Giardia lamblia DEAD box RNA helicase Vasa Get druggable targets OG5_126849 All targets in OG5_126849
Leishmania donovani ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Toxoplasma gondii DEAD (Asp-Glu-Ala-Asp) box polypeptide DDX3X Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma congolense ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Neospora caninum VASA RNA helicase, related Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma cruzi ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus granulosus ATP dependent RNA helicase ded1 Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus multilocularis ATP dependent RNA helicase DDX3X Get druggable targets OG5_126849 All targets in OG5_126849
Cryptosporidium hominis DEAD box polypeptide, Y chromosome-related Get druggable targets OG5_126849 All targets in OG5_126849
Theileria parva RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Giardia lamblia ATP-dependent RNA helicase-like protein Get druggable targets OG5_126849 All targets in OG5_126849
Brugia malayi ATP-dependent RNA helicase An3 Get druggable targets OG5_126849 All targets in OG5_126849
Mycobacterium ulcerans ATP-dependent RNA helicase, RhlE1 Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus granulosus DEAD box ATP dependent RNA helicase Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium yoelii DEAD box polypeptide, Y chromosome-related Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium vivax DEAD/DEAH box helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus multilocularis ATP dependent RNA helicase DDX3X Get druggable targets OG5_126849 All targets in OG5_126849
Onchocerca volvulus Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium falciparum ATP-dependent RNA helicase DBP1, putative Get druggable targets OG5_126849 All targets in OG5_126849
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126849 All targets in OG5_126849
Leishmania infantum ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Leishmania braziliensis ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus granulosus atp dependent rna helicase ddxx Get druggable targets OG5_126849 All targets in OG5_126849
Schistosoma japonicum ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative Get druggable targets OG5_126849 All targets in OG5_126849
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0048 0.8795 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0048 0.8795 1
Brugia malayi SH2 domain containing protein 0.0048 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0048 0.8795 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.8795 0.8795
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.8795 1
Echinococcus multilocularis epidermal growth factor receptor 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica cysteine surface protein, putative 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK/Met protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Brugia malayi C-terminal src kinase protein 1 0.0048 0.8795 1
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.8795 0.8795
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.8795 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0048 0.8795 1
Plasmodium falciparum protein kinase, putative 0.0048 0.8795 1
Giardia lamblia Kinase, NEK 0.0048 0.8795 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Entamoeba histolytica ankyrin repeat protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.8795 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Brugia malayi hypothetical protein 0.0048 0.8795 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Leishmania major protein kinase, putative 0.0048 0.8795 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein 0.0048 0.8795 0.8795
Schistosoma mansoni serine/threonine RGC 0.0048 0.8795 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.8795 1
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.8795 0.8795
Brugia malayi Furin-like cysteine rich region family protein 0.0048 0.8795 1
Entamoeba histolytica receptor protein kinase, putative 0.0048 0.8795 0.8795
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK/CSK protein kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.8795 0.8795
Toxoplasma gondii protein kinase domain-containing protein 0.0048 0.8795 1
Echinococcus multilocularis insulin receptor 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0048 0.8795 1
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.8795 0.8795
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.8795 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Echinococcus multilocularis activated cdc42 kinase 1 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Entamoeba histolytica hypothetical protein 0.0048 0.8795 0.8795
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis protein kinase atn1, putative 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein 0.0053 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Brugia malayi Tyrosine-protein kinase PR2 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Echinococcus granulosus epidermal growth factor receptor 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0048 0.8795 1
Echinococcus granulosus protein kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.8795 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.8795 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.8795 1
Echinococcus granulosus protein tyrosine kinase 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Echinococcus multilocularis protein tyrosine kinase 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein 0.0053 1 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0048 0.8795 1
Toxoplasma gondii protein kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0048 0.8795 1
Echinococcus multilocularis protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0053 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein 0.0048 0.8795 0.8795
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.8795 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0048 0.8795 0.8795
Trypanosoma cruzi protein kinase, putative 0.0048 0.8795 1
Trichomonas vaginalis AGC family protein kinase 0.0048 0.8795 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Brugia malayi Guanylyl cyclase protein 23 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Brugia malayi Receptor family ligand binding region containing protein 0.0048 0.8795 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0048 0.8795 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.8795 0.8795
Plasmodium vivax protein kinase, putative 0.0048 0.8795 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.8795 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Leishmania major protein kinase, putative 0.0048 0.8795 0.5
Brugia malayi SRC-1 0.0048 0.8795 1
Toxoplasma gondii STE kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Echinococcus multilocularis activin receptor type 0.0048 0.8795 1
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.8795 1
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0048 0.8795 0.8795
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.8795 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.8795 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.8795 1
Plasmodium falciparum protein kinase, putative 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) SRC-1 0.0048 0.8795 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.8795 0.8795
Brugia malayi protein-tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0048 0.8795 1
Trichomonas vaginalis STE family protein kinase 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Plasmodium falciparum tyrosine kinase-like protein 0.0048 0.8795 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Brugia malayi hypothetical protein 0.0048 0.8795 1
Echinococcus granulosus activated cdc42 kinase 1 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Echinococcus multilocularis c src tyrosine kinase 0.0048 0.8795 1
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.8795 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.8795 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0048 0.8795 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase shark 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Trypanosoma brucei protein kinase, putative 0.0048 0.8795 1
Echinococcus granulosus insulin receptor 0.0048 0.8795 1
Giardia lamblia Kinase 0.0048 0.8795 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine protein kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus granulosus activated cdc42 kinase 1 0.0048 0.8795 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0048 0.8795 1
Brugia malayi hypothetical protein 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus granulosus epidermal growth factor receptor 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Echinococcus multilocularis epidermal growth factor receptor 0.0048 0.8795 1
Mycobacterium ulcerans ATP-dependent RNA helicase, RhlE1 0.0008 0.0000000029022 0.5
Echinococcus granulosus tyrosine kinase 0.0048 0.8795 1
Brugia malayi integrin-linked kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Trypanosoma brucei Pseudokinase, putative 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0048 0.8795 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trypanosoma cruzi protein kinase, putative 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Brugia malayi SH2 domain containing protein 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0053 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0048 0.8795 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica tyrosin kinase, putative 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0048 0.8795 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.8795 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Entamoeba histolytica receptor protein kinase, putative 0.0048 0.8795 0.8795
Onchocerca volvulus Tyrosine kinase homolog 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0048 0.8795 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Echinococcus granulosus activin receptor type 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK/EPH protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus multilocularis integrin linked protein kinase 0.0048 0.8795 1
Echinococcus multilocularis natriuretic peptide receptor 1 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.8795 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TK family protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0048 0.8795 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein 0.0048 0.8795 0.8795
Brugia malayi ephrin receptor 1 precursor 0.0048 0.8795 1
Entamoeba histolytica protein kinase, putative 0.0048 0.8795 0.8795
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Brugia malayi Raf kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine kinase 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0048 0.8795 1
Echinococcus granulosus tyrosine kinase 0.0048 0.8795 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Echinococcus granulosus tyrosine protein kinase ABL1 0.0048 0.8795 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0048 0.8795 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica serine/threonine kinase, putative 0.0048 0.8795 0.8795
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0048 0.8795 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Entamoeba histolytica ankyrin repeat protein 0.0048 0.8795 0.8795
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) protein kinase domain-containing protein 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Echinococcus multilocularis FL cytokine receptor 0.0048 0.8795 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0048 0.8795 1
Schistosoma mansoni hypothetical protein 0.0048 0.8795 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0048 0.8795 1
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Schistosoma mansoni protein tyrosine kinase 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.8795 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Echinococcus multilocularis ephrin type A receptor 4 A 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Leishmania major hypothetical protein, conserved 0.0048 0.8795 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0048 0.8795 0.8795
Loa Loa (eye worm) TK/ACK protein kinase 0.0048 0.8795 1
Echinococcus multilocularis protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Onchocerca volvulus 0.0048 0.8795 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0048 0.8795 0.8795
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.8795 1
Echinococcus multilocularis heat shock protein 70 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0048 0.8795 1
Schistosoma mansoni ephrin receptor 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Echinococcus granulosus receptor type guanylyl cyclase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein 0.0048 0.8795 0.8795
Echinococcus granulosus c src tyrosine kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0048 0.8795 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Giardia lamblia Protein 21.1 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.8795 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.8795 1
Echinococcus granulosus integrin linked protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica protein kinase domain containing protein 0.0048 0.8795 0.8795
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Echinococcus multilocularis tyrosine kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Plasmodium falciparum tyrosine kinase-like protein 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795
Plasmodium falciparum protein kinase, putative 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein 0.0048 0.8795 0.8795
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0048 0.8795 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Schistosoma mansoni ephrin receptor 0.0048 0.8795 1
Echinococcus granulosus tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0048 0.8795 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0048 0.8795 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Echinococcus granulosus atp dependent rna helicase ddxx 0.0008 0.0000000029022 0.0000000032998
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Schistosoma mansoni protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Giardia lamblia Kinase, NEK 0.0048 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0048 0.8795 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0048 0.8795 1
Entamoeba histolytica hypothetical protein 0.0048 0.8795 0.8795
Trypanosoma brucei Flagellum attachment zone protein 20 0.0048 0.8795 1
Loa Loa (eye worm) TK protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.8795 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.8795 1
Echinococcus multilocularis transfer RNA-Thr 0.0048 0.8795 1
Schistosoma mansoni tyrosine kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.8795 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0048 0.8795 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.8795 1
Trichomonas vaginalis TKL family protein kinase 0.0048 0.8795 1
Entamoeba histolytica tyrosine kinase, putative 0.0048 0.8795 0.8795

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17 uM Inhibition of human recombinant DDX3 ATPase activity expressed in Escherichia coli assessed as [gamma-32P] ATP hydrolysis after 5 mins by densitometric analysis ChEMBL. 22300661
IC50 (binding) = 65 uM Inhibition of human recombinant DDX3 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in to single stranded nucleic acid by laser scanning densitometric analysis ChEMBL. 22300661
IC50 (binding) > 500 uM Inhibition of human recombinant DDX1 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in to single stranded nucleic acid by laser scanning densitometric analysis ChEMBL. 22300661

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.