Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | pyruvate carboxylase | 0.0448 | 0.2839 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0448 | 0.2839 | 1 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0448 | 0.2839 | 0.2839 |
Schistosoma mansoni | pyruvate carboxylase | 0.0448 | 0.2839 | 0.2839 |
Trichomonas vaginalis | AGC family protein kinase | 0.0333 | 0.1712 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0333 | 0.1712 | 1 |
Leishmania major | protein kinase, putative | 0.0333 | 0.1712 | 0.1712 |
Echinococcus multilocularis | aurora kinase A | 0.0333 | 0.1712 | 0.1712 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0448 | 0.2839 | 0.5074 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.1175 | 1 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.085 | 0.6803 | 1 |
Trypanosoma brucei | aurora B kinase | 0.0333 | 0.1712 | 0.1712 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0333 | 0.1712 | 0.1732 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.1175 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0333 | 0.1712 | 1 |
Trypanosoma brucei | unspecified product | 0.0294 | 0.1329 | 0.1329 |
Giardia lamblia | Aurora kinase | 0.0333 | 0.1712 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.1175 | 1 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0333 | 0.1712 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0333 | 0.1712 | 0.1732 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0448 | 0.2839 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0333 | 0.1712 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0448 | 0.2839 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.0333 | 0.1712 | 0.1732 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0333 | 0.1712 | 0.1712 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0333 | 0.1712 | 0.1732 |
Toxoplasma gondii | pyruvate carboxylase | 0.0448 | 0.2839 | 0.2839 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0448 | 0.2839 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0333 | 0.1712 | 0.1712 |
Schistosoma mansoni | protein kinase | 0.0333 | 0.1712 | 0.1712 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0333 | 0.1712 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0448 | 0.2839 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0333 | 0.1712 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0333 | 0.1712 | 1 |
Leishmania major | carboxylase, putative | 0.0448 | 0.2839 | 0.2839 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0333 | 0.1712 | 1 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0448 | 0.2839 | 0.2839 |
Trichomonas vaginalis | AGC family protein kinase | 0.0333 | 0.1712 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0448 | 0.2839 | 0.2839 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0165 | 0.0061 | 0.0061 |
Chlamydia trachomatis | biotin carboxylase | 0.0406 | 0.2433 | 1 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.02 | 0.0405 | 0.2087 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0333 | 0.1712 | 0.1712 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0333 | 0.1712 | 0.306 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0727 | 0.5594 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0448 | 0.2839 | 0.2839 |
Loa Loa (eye worm) | AUR protein kinase | 0.0333 | 0.1712 | 0.1732 |
Entamoeba histolytica | protein kinase, putative | 0.0333 | 0.1712 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.085 | 0.6803 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.1134 | 0.9595 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.1134 | 0.9595 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.1175 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.1175 | 1 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0448 | 0.2839 | 0.5074 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0448 | 0.2839 | 0.2839 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0448 | 0.2839 | 1 |
Toxoplasma gondii | AGC kinase | 0.0165 | 0.0061 | 0.0061 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0448 | 0.2839 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0448 | 0.2839 | 0.2839 |
Loa Loa (eye worm) | AUR protein kinase | 0.0333 | 0.1712 | 0.1732 |
Echinococcus granulosus | aurora kinase A | 0.0333 | 0.1712 | 0.1712 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0448 | 0.2839 | 0.2839 |
Toxoplasma gondii | aurora kinase | 0.0333 | 0.1712 | 0.1712 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.1175 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.