Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydropteridine reductase | 0.0141 | 0.0515 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.059 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0141 | 0.0515 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0141 | 0.0515 | 0.8729 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0141 | 0.0515 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0141 | 0.0515 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.2082 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0156 | 0.059 | 0.0217 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0081 | 0.1368 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0141 | 0.0515 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0141 | 0.0515 | 0.5 |
Onchocerca volvulus | 0.0141 | 0.0515 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0081 | 0.1368 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0141 | 0.0515 | 0.8729 |
Onchocerca volvulus | 0.0141 | 0.0515 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0515 | 0.8729 |
Loa Loa (eye worm) | oxidoreductase | 0.0141 | 0.0515 | 0.8729 |
Leishmania major | oxidoreductase-like protein | 0.0141 | 0.0515 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0141 | 0.0515 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0141 | 0.0515 | 0.8729 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0141 | 0.0515 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.2082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.059 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0141 | 0.0515 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0156 | 0.059 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0141 | 0.0515 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0141 | 0.0515 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0141 | 0.0515 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0156 | 0.059 | 0.0217 |
Brugia malayi | Muscleblind-like protein | 0.0156 | 0.059 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0849 | 0.3973 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.2082 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.2082 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.2082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0081 | 0.1368 |
Trichomonas vaginalis | hypothetical protein | 0.2082 | 1 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.2082 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.2082 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0081 | 0.1368 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0141 | 0.0515 | 0.8729 |
Trypanosoma brucei | pteridine reductase 1 | 0.0141 | 0.0515 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.33 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.035 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.985 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.981 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.929 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.851 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.701 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.686 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.543 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.