Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | No references |
Homo sapiens | aurora kinase A | Starlite/ChEMBL | No references |
Homo sapiens | aurora kinase B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | aurora kinase B | 303 aa | 299 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.0545 | 0.8296 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0204 | 0.0657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0028 | 0.0423 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0025 | 0.0383 |
Loa Loa (eye worm) | oxidoreductase | 0.0204 | 0.0657 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0016 | 0.0238 |
Schistosoma mansoni | protein kinase | 0.0136 | 0.0431 | 0.6561 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0003 | 0.0052 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0011 | 0.0016 | 0.0238 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0204 | 0.0657 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0204 | 0.0657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0037 | 0.0568 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0204 | 0.0657 | 0.0236 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0204 | 0.0657 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0037 | 0.0568 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0136 | 0.0431 | 0.6561 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.0016 | 0.0238 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0204 | 0.0657 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0136 | 0.0431 | 0.6561 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0204 | 0.0657 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0204 | 0.0657 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0204 | 0.0657 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0238 |
Giardia lamblia | Aurora kinase | 0.0136 | 0.0431 | 0.5 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0136 | 0.0431 | 0.6561 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.3016 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0136 | 0.0431 | 0.6561 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0028 | 0.0423 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0136 | 0.0431 | 0.6561 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.0585 | 0.8904 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0037 | 0.0568 |
Brugia malayi | serine/threonine kinase 12 | 0.0136 | 0.0431 | 0.6561 |
Onchocerca volvulus | 0.0167 | 0.0532 | 0.8099 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0011 | 0.0016 | 0.0238 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0008 | 0.0004 | 0.0056 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.3016 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0136 | 0.0431 | 0.6561 |
Leishmania major | oxidoreductase-like protein | 0.0204 | 0.0657 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0136 | 0.0431 | 0.6561 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0028 | 0.0423 |
Onchocerca volvulus | 0.0204 | 0.0657 | 1 | |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.3016 | 1 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0204 | 0.0657 | 1 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0204 | 0.0657 | 0.0236 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0204 | 0.0657 | 0.0236 |
Leishmania major | pteridine reductase 1 | 0.0204 | 0.0657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0238 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.0016 | 0.0238 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0204 | 0.0657 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0204 | 0.0657 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.0585 | 0.8904 |
Echinococcus multilocularis | aurora kinase A | 0.0136 | 0.0431 | 0.6561 |
Trypanosoma brucei | pteridine reductase 1 | 0.0204 | 0.0657 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0011 | 0.0016 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0238 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.3016 | 1 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0016 | 0.0238 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0025 | 0.0383 |
Schistosoma mansoni | dihydropteridine reductase | 0.0204 | 0.0657 | 1 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0025 | 0.0383 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0204 | 0.0657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0238 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0204 | 0.0657 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0204 | 0.0657 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0016 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0037 | 0.0568 |
Trichomonas vaginalis | hypothetical protein | 0.3016 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.3016 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.3016 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.3016 | 1 | 1 |
Onchocerca volvulus | 0.0204 | 0.0657 | 1 | |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0204 | 0.0657 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0204 | 0.0657 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0011 | 0.0016 | 0.0238 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0136 | 0.0431 | 0.6561 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0204 | 0.0657 | 0.0236 |
Echinococcus granulosus | aurora kinase A | 0.0136 | 0.0431 | 0.6561 |
Echinococcus granulosus | twitchin | 0.0015 | 0.0029 | 0.0439 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.0016 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0238 |
Echinococcus granulosus | Immunoglobulin | 0.0011 | 0.0016 | 0.0238 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0204 | 0.0657 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | > 5.3 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KDR | ChEMBL. | No reference |
Ki (functional) | = 5.9 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK6 | ChEMBL. | No reference |
Ki (functional) | = 7.1 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK12 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.