Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | oligopeptidase b | 0.0079 | 0.0196 | 0.0196 |
Trichomonas vaginalis | set domain proteins, putative | 0.0278 | 0.1237 | 0.1237 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0226 | 0.0965 | 0.0965 |
Echinococcus multilocularis | tumor protein p63 | 0.0396 | 0.1858 | 0.1858 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1945 | 1 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0079 | 0.0196 | 0.0196 |
Trypanosoma brucei | protein kinase, putative | 0.1945 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0079 | 0.0196 | 0.0196 |
Onchocerca volvulus | 0.0058 | 0.0083 | 0.067 | |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1945 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.0696 | 0.0696 |
Echinococcus granulosus | tumor protein p63 | 0.0396 | 0.1858 | 0.1858 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0175 | 0.0696 | 0.5631 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0087 | 0.0235 | 0.0235 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.0965 | 0.0965 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0061 | 0.0061 |
Leishmania major | oligopeptidase b | 0.0079 | 0.0196 | 0.0196 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.0235 | 0.0235 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0235 | 0.0235 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1945 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0061 | 0.0061 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1945 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0696 | 0.0696 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1945 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1945 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1945 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1945 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1945 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0.0196 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0087 | 0.0235 | 0.0235 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.0696 | 0.0696 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1945 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.0696 | 0.0696 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 0.0965 | 0.7803 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0087 | 0.0235 | 0.0235 |
Onchocerca volvulus | 0.0278 | 0.1237 | 1 | |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0.0196 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0087 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1945 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.0696 | 0.0696 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0079 | 0.0196 | 0.0196 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 0.0965 | 0.0965 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0269 | 0.1194 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.0083 | 0.0083 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0083 | 0.0083 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1945 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0079 | 0.0196 | 0.0196 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0079 | 0.0196 | 0.0196 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.0696 | 0.0696 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0244 | 0.106 | 0.106 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1945 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0079 | 0.0196 | 0.0196 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1945 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0244 | 0.106 | 0.106 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1945 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 0.0965 | 0.0965 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1945 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1945 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0079 | 0.0196 | 0.164 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.0696 | 0.0696 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 0.0965 | 0.0965 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.0696 | 0.0696 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0079 | 0.0196 | 0.0196 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1945 | 1 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.0696 | 0.0696 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.0235 | 0.0235 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0087 | 0.0235 | 0.0235 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.0696 | 0.0696 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.0235 | 0.0235 |
Mycobacterium tuberculosis | Probable peptidase | 0.0079 | 0.0196 | 0.164 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.0522 | 0.4371 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1945 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of mouse recombinant FAP expressed in HEK293 cells assessed as pNA release from Ala-Pro-p-nitroanilide pre-incubated with enzyme for 15 mins prior to substrate addition by fluorescence technique | ChEMBL. | 22525314 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant PREP expressed in Escherichia coli assessed as pNA release from Z-Gly-Pro-p-nitroanilide pre-incubated with enzyme for 15 mins prior to substrate addition by fluorescence technique | ChEMBL. | 22525314 |
IC50 (binding) | > 100 uM | Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | ChEMBL. | 22525314 |
IC50 (binding) | > 100 uM | Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | ChEMBL. | 22525314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.