Detailed information for compound 163877

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 341.358 | Formula: C19H19NO5
  • H donors: 0 H acceptors: 1 LogP: 3.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(ccnc2cc1OC)Oc1cccc(c1OC)OC
  • InChi: 1S/C19H19NO5/c1-21-15-6-5-7-16(19(15)24-4)25-14-8-9-20-13-11-18(23-3)17(22-2)10-12(13)14/h5-11H,1-4H3
  • InChiKey: NQWDTJUCVNPURX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Platelet-derived growth factor receptor beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.1746 0.1743
Brugia malayi hypothetical protein 0.0043 0.0224 0.0639
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0224 0.0221
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0152 0.0149
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0265 0.0262
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0026 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0496
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1333 0.6372
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0003 0.0044
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0195 0.0192
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0093 0.0515
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0453 1
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0093 0.0263
Brugia malayi Latrophilin receptor protein 2 0.0103 0.0688 0.1969
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0043 0.0224 0.1673
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2092 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0152 0.0152
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0093 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1333 0.6372
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0152 0.0149
Leishmania major cytochrome p450-like protein 0.0015 0.0003 0.0044
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0152 0.0152
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0581 0.5
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0011 0.0029
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.1277 0.3658
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0152 0.0622
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0195 0.429
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0035 0.0253
Brugia malayi nuclear receptor NHR-88 0.0034 0.0152 0.0431
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Echinococcus granulosus transient receptor potential gamma protein 0.0215 0.1565 0.1563
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0224 0.0921
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0404 0.8911
Schistosoma mansoni transcription factor LCR-F1 0.0462 0.3491 0.3491
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.0581 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Echinococcus multilocularis TRP (transient receptor potential) channel 0.008 0.0511 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0159 0.0892
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0093 0.1063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0152 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0496
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0152 0.0152
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0159 0.0155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0103 0.0688 0.1969
Brugia malayi ecdysteroid receptor 0.0034 0.0152 0.0431
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0159 0.4594
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0581 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0683 0.0683
Leishmania major cathepsin L-like protease 0.0019 0.0035 0.0747
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0159 0.0892
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1411 0.6745
Schistosoma mansoni cytochrome P450 0.0015 0.0003 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0152 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0152 0.0431
Brugia malayi nuclear hormone receptor 0.0034 0.0152 0.0431
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0159 0.3486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0195 0.0927
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Brugia malayi Doublecortin family protein 0.0043 0.0224 0.0639
Brugia malayi Cathepsin L-like precursor 0.0019 0.0035 0.0097
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.1277 0.5274
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0195 0.0801
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0322
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0104
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0152 0.0152
Toxoplasma gondii hypothetical protein 0.0031 0.0125 0.0702
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0222 0.1619 0.6686
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0035 0.0032
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0581 1
Schistosoma mansoni hypothetical protein 0.0366 0.2743 0.2743
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0103 0.0688 0.0685
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0152 0.0149
Onchocerca volvulus 0.0016 0.0011 0.0077
Brugia malayi Cathepsin L-like precursor 0.0019 0.0035 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0195 0.429
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0105 0.0496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0152 0.0622
Leishmania major cathepsin L-like protease 0.0073 0.0453 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0152 0.113
Brugia malayi conserved hypotetical protein 0.0016 0.0011 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2092 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0159 0.0155
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0035 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Leishmania major cathepsin L-like protease 0.0019 0.0035 0.0747
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0224 0.0221
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0152 0.0431
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0026 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0152 0.0431
Brugia malayi ecdysone receptor 0.0016 0.0011 0.0029
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0125 0.1659
Leishmania major cathepsin L-like protease 0.0073 0.0453 1
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0453 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0105 0.0496
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0003 0.0044
Entamoeba histolytica hypothetical protein 0.0462 0.3491 1
Echinococcus multilocularis transcription factor eb 0.0114 0.0778 0.0775
Echinococcus multilocularis transient receptor potential ion channel A 0.0208 0.1509 0.1507
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0622
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0152 0.0149
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0159 0.3486
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0159 0.0451
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0093 0.1599
Schistosoma mansoni transient receptor potential channel 4 0.0215 0.1565 0.1565
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0185 0.0182
Echinococcus multilocularis short transient receptor potential channel 6 0.0142 0.0997 0.0994
Schistosoma mansoni hypothetical protein 0.0103 0.0688 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Schistosoma mansoni lipoxygenase 0.0181 0.1299 0.1299
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0011 0.0011
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0011 0.0008
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0003 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0035 0.0161
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0093 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0152 0.0622
Loa Loa (eye worm) hypothetical protein 0.0103 0.0688 0.2839
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0126 0.0126
Echinococcus granulosus TRP transient receptor potential channel 0.008 0.0511 0.0508
Onchocerca volvulus 0.0019 0.0035 0.0253
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0152 0.0149
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0453 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0152 0.0431
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0026 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0152 0.0431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0683 0.068
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0114 0.0778 0.2227
Brugia malayi hypothetical protein 0.0043 0.0224 0.0639
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.0181 0.0515
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0152 0.0149
Brugia malayi Cathepsin L-like precursor 0.0019 0.0035 0.0097
Brugia malayi steroid hormone receptor 0.0034 0.0152 0.0431
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0262 0.1933 0.1933
Schistosoma mansoni rab6-interacting 0.0043 0.0224 0.0224
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0035 0.0032
Toxoplasma gondii cathepsin CPL 0.0019 0.0035 0.0182
Loa Loa (eye worm) histone methyltransferase 0.0038 0.0185 0.0759
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0581 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0076 0.0308
Brugia malayi hypothetical protein 0.016 0.1135 0.3249
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0233 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0035 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0104
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0233 0.0668
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0341 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0224 0.0221
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.0581 1
Brugia malayi Probable ClpP-like protease 0.0089 0.0581 0.1661
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0259 0.1907 0.1905
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0152 0.0431
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0105 0.0496
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0622
Trichomonas vaginalis helicase, putative 0.0028 0.0105 0.0496
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0622
Echinococcus granulosus cpg binding protein 0.0131 0.0906 0.0904
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0105 0.0496
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0159 0.3486
Echinococcus granulosus GPCR family 2 0.0103 0.0688 0.0685
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0581 1
Brugia malayi hypothetical protein 0.0238 0.1746 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.1746 0.1743
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.1173 0.1173
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0152 0.0152
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0001 0.0003
Brugia malayi hypothetical protein 0.0016 0.0011 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0152 0.0431
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0265 0.1501
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0011 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0035 0.0161
Loa Loa (eye worm) cysteine protease 0.0019 0.0035 0.0139
Onchocerca volvulus 0.0034 0.0152 0.113
Schistosoma mansoni polycystin 1-related 0.0043 0.0224 0.0224
Brugia malayi hypothetical protein 0.0018 0.0026 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0152 0.0431
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0325 0.2421 0.6935
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0076 0.1648
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0622
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0035 0.0161
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0011 0.0008
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0581 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0104
Echinococcus multilocularis GPCR, family 2 0.0103 0.0688 0.0685
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0152 0.0152
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0195 0.0927
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0224 0.3857
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2092 1
Echinococcus multilocularis cysteine protease 0.0019 0.0035 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0035 0.0161
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0035 0.06
Schistosoma mansoni nuclear receptor 0.0016 0.0011 0.0011
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.0581 0.0578
Brugia malayi nuclear hormone receptor 0.0016 0.0011 0.0029
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0003 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0003
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0265 0.1261
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0035 0.06
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0224 0.0221
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0159 0.273
Brugia malayi Cytochrome P450 family protein 0.0024 0.0076 0.0213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0496
Leishmania major cytochrome p450-like protein 0.0015 0.0003 0.0044
Loa Loa (eye worm) ctsf protein 0.0019 0.0035 0.0139
Onchocerca volvulus 0.0016 0.0011 0.0077
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.2092 0.599
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1333 0.6372
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0462 0.3491 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0035 0.0032
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.1277 0.1275
Loa Loa (eye worm) DR-78 0.0016 0.0011 0.0042
Onchocerca volvulus 0.0019 0.0035 0.0253
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0159 0.0155
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0105 0.0496
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0093 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1333 0.6372
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0093 0.0439
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0622
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0331 0.7315
Brugia malayi nuclear receptor NHR-67 0.0016 0.0011 0.0029
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0011 0.0008
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0011 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1333 0.6372
Brugia malayi nuclear receptor RXR 0.0018 0.0026 0.0072
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0152 0.0152
Schistosoma mansoni lipoxygenase 0.0259 0.1907 0.1907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0076 0.0308
Loa Loa (eye worm) cytochrome P450 0.0015 0.0003 0.0008
Entamoeba histolytica hypothetical protein 0.0462 0.3491 1
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0152 0.0622
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0011 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0103 0.0688 0.0685
Echinococcus granulosus mixed lineage leukemia protein mll 0.0031 0.0126 0.0123
Entamoeba histolytica cysteine protease, putative 0.0019 0.0035 0.01
Loa Loa (eye worm) hypothetical protein 0.0238 0.1746 0.721
Brugia malayi Cytochrome P450 family protein 0.0024 0.0076 0.0213
Schistosoma mansoni transient receptor potential channel 0.0215 0.1565 0.1565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0161 0.066
Onchocerca volvulus 0.0049 0.0265 0.1985
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0025 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0622
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0341 1
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0035 0.0253
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0265 0.4211
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0093 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0152 0.0622
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0622
Leishmania major cathepsin L-like protease 0.0019 0.0035 0.0747
Brugia malayi Cytochrome P450 family protein 0.0035 0.0161 0.0458
Brugia malayi MH2 domain containing protein 0.0131 0.0906 0.2592
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0152 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0496
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0125 0.2118
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0159 0.0155
Echinococcus granulosus histone acetyltransferase KAT2B 0.016 0.1137 0.1135
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0159 0.0651
Loa Loa (eye worm) hypothetical protein 0.0073 0.0455 0.1874
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0035 0.0161
Schistosoma mansoni hypothetical protein 0.0103 0.0688 0.0688
Brugia malayi hypothetical protein 0.0016 0.0011 0.0029
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0265 0.0758
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0325 0.2421 1
Loa Loa (eye worm) hypothetical protein 0.0215 0.1565 0.6463
Onchocerca volvulus 0.0019 0.0035 0.0253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0035 0.0161
Echinococcus granulosus cathepsin l1 0.0019 0.0035 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0496
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0195 0.0192
Echinococcus granulosus geminin 0.0366 0.2743 0.2741
Loa Loa (eye worm) hypothetical protein 0.0325 0.2421 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0003 0.0011
Trichomonas vaginalis hypothetical protein 0.0015 0.0003 0.0011
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.1277 0.1275
Trypanosoma brucei glucosidase, putative 0.004 0.0195 0.429
Brugia malayi hypothetical protein 0.0018 0.0026 0.0072
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0159 0.0155
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0076 0.1648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0683 0.068
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0224 0.0221
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0011 0.0011
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0026 0.0023
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0093 0.0379
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0152 0.0149
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0011 0.0029
Schistosoma mansoni cpg binding protein 0.0124 0.0851 0.0851
Schistosoma mansoni alpha-glucosidase 0.0154 0.1084 0.1084
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0011 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0105 0.0496
Schistosoma mansoni hypothetical protein 0.0222 0.1619 0.1619
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0496
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0093 0.0093
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0152 0.0431
Onchocerca volvulus 0.0019 0.0035 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0683 0.0683
Schistosoma mansoni nuclear receptor 0.0016 0.0011 0.0011
Brugia malayi nuclear receptor RXR 0.0016 0.0011 0.0029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0152 0.0149
Schistosoma mansoni loxhd1 0.0043 0.0224 0.0224
Brugia malayi latrophilin 2 splice variant baaae 0.0222 0.1619 0.4636
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0185 0.0182
Loa Loa (eye worm) hypothetical protein 0.0135 0.0941 0.3883
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0093 0.0263
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0093 0.2031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0325 0.2421 0.6935
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.1173 0.1171
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0076 0.1648
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1411 0.6745
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0011 0.0077
Brugia malayi CXXC zinc finger family protein 0.0124 0.0851 0.2436
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0195 0.0555
Echinococcus multilocularis dnaJ subfamily B 0.1297 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0035 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0035 0.0161
Loa Loa (eye worm) fibroinase 0.0019 0.0035 0.0139
Brugia malayi cytochrome P450 0.0015 0.0003 0.0006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0011 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0104
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0093 0.2031
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0035 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0152 0.0149
Loa Loa (eye worm) hypothetical protein 0.016 0.1135 0.4686
Schistosoma mansoni hypothetical protein 0.0043 0.0224 0.0224
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0011 0.0008
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.0581 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2092 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0152 0.0149
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0035 0.0747
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0159 0.3486
Leishmania major cathepsin L-like protease 0.0019 0.0035 0.0747
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0011 0.0008
Brugia malayi Cathepsin L-like precursor 0.0019 0.0035 0.0097
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0093 0.2031
Schistosoma mansoni rab6-interacting 0.0043 0.0224 0.0224
Schistosoma mansoni coup transcription factor 0.0034 0.0152 0.0152
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0035 0.0161
Brugia malayi Cathepsin L-like precursor 0.0019 0.0035 0.0097
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0195 0.0927
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0462 0.3491 0.3489
Onchocerca volvulus 0.0019 0.0035 0.0253
Onchocerca volvulus 0.0019 0.0035 0.0253
Trichomonas vaginalis chaperonin, putative 0.0026 0.0093 0.0439
Onchocerca volvulus 0.016 0.1135 0.8512
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0265 0.1501
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1333 0.6372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Schistosoma mansoni transient receptor potential channel 0.0142 0.0997 0.0997
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0152 0.0149
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0581 0.3313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0011 0.0008
Onchocerca volvulus 0.0124 0.0851 0.6383
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0152 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0683 0.1954
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0195 0.11
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0103 0.0688 0.0685
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0195 0.0927
Loa Loa (eye worm) hypothetical protein 0.0089 0.0581 0.2395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0341 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Schistosoma mansoni hypothetical protein 0.0103 0.0688 0.0688
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.1333 1
Onchocerca volvulus 0.0043 0.0224 0.1673
Schistosoma mansoni transient receptor potential channel 0.0142 0.0997 0.0997
Brugia malayi hypothetical protein 0.0462 0.3491 1
Echinococcus granulosus RUN 0.0043 0.0224 0.0221
Schistosoma mansoni hypothetical protein 0.0366 0.2743 0.2743
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0035 0.0161
Entamoeba histolytica hypothetical protein 0.0462 0.3491 1
Echinococcus granulosus short transient receptor potential channel 6 0.0142 0.0997 0.0994
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0341 0.5857
Schistosoma mansoni zinc finger protein 0.0016 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2092 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0011 0.0029
Leishmania major cathepsin L-like protease 0.0073 0.0453 1
Schistosoma mansoni hypothetical protein 0.0462 0.3491 0.3491
Schistosoma mansoni survival motor neuron protein 0.0049 0.0265 0.0265
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0011 0.0029
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0126 0.0123
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0265 0.1261
Brugia malayi tailless protein 0.0016 0.0011 0.0029
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0011 0.0011
Echinococcus granulosus transcription factor eb 0.0114 0.0778 0.0775
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0035 0.01
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0035 0.0032
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0003 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0152 0.0431
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0233 0.4015
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0906 0.3738
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0152 0.0149
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.1277 0.1275
Schistosoma mansoni cpg binding protein 0.0131 0.0906 0.0906
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0581 1
Echinococcus multilocularis cysteine protease 0.0019 0.0035 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0195 0.0927
Schistosoma mansoni alpha-glucosidase 0.0154 0.1084 0.1084
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0035 0.0097
Leishmania major cytochrome p450-like protein 0.0024 0.0076 0.1648
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0581 0.3313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0035 0.0161
Loa Loa (eye worm) latrophilin receptor protein 2 0.0103 0.0688 0.2839
Schistosoma mansoni hypothetical protein 0.0049 0.0265 0.0265
Schistosoma mansoni vesicular amine transporter 0.0018 0.003 0.003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0238 0.1746 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0683 0.2818
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.2092 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0152 0.113
Brugia malayi Cathepsin L-like precursor 0.0019 0.0035 0.0097
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0224 0.3465
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0152 0.0149
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0195 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0152 0.0431
Brugia malayi isocitrate dehydrogenase 0.0035 0.0159 0.0451
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0035 0.0747
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0683 0.068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0224 0.0921
Schistosoma mansoni hypothetical protein 0.1297 1 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0031 0.0126 0.0123
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0159 0.0159
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0159 0.0155
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.008 0.0511 0.2105
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0152 0.0149
Loa Loa (eye worm) hypothetical protein 0.0043 0.0224 0.0921
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0152 0.0149
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0105 0.0496
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0159 0.3486
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0152 0.0152
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0035 0.0035
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0011 0.0029
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0259 0.1907 0.1905
Onchocerca volvulus 0.0103 0.0691 0.5178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0683 0.0683
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0152 0.0149
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0114 0.0774 0.3193
Onchocerca volvulus 0.0019 0.0035 0.0253
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0195 0.0927
Brugia malayi Transient-receptor-potential like protein 0.008 0.0511 0.146
Schistosoma mansoni hypothetical protein 0.0103 0.0688 0.0688
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0026 0.0104
Echinococcus multilocularis geminin 0.0366 0.2743 0.2741
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0076 0.1254
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0011 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0152 0.0431
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0341 0.0338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1333 0.6372
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0195 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0462 0.3491 0.3489
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0622
Echinococcus granulosus short transient receptor potential channel 6 0.0142 0.0997 0.0994
Brugia malayi Cytochrome P450 family protein 0.0015 0.0003 0.0006
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0224 0.0221
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0195 0.429
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0035 0.06
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0453 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0105 0.0496
Echinococcus multilocularis cpg binding protein 0.0131 0.0906 0.0904
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0104
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0195 0.0558
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0683 0.068
Echinococcus granulosus transient receptor potential ion channel A 0.0208 0.1509 0.1507
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0152 0.113
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0195 0.0927
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.2092 0.8638
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0105 0.0496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0152 0.0622
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0035 0.0161
Brugia malayi nuclear receptor NHR-88 0.0016 0.0011 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0152 0.0431
Leishmania major cathepsin L-like protease 0.0019 0.0035 0.0747
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.0581 0.0581
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0126 0.0123
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0093 0.0093
Loa Loa (eye worm) CXXC zinc finger family protein 0.0124 0.0851 0.3513
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0152 0.0431
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0159 0.2266
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0195 0.0927
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0035 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0139
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.1173 0.336
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0076 0.0308
Echinococcus multilocularis transient receptor potential gamma protein 0.0215 0.1565 0.1563
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0152 0.0149
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0103 0.0688 0.0685
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0906 0.3738
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0152 0.0622
Echinococcus multilocularis RUN 0.0043 0.0224 0.0221
Schistosoma mansoni cpg binding protein 0.0131 0.0906 0.0906
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0453 1
Schistosoma mansoni alpha glucosidase 0.004 0.0195 0.0195
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0035 0.0032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0011 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0114 0.0774 0.3193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0042
Loa Loa (eye worm) acetyltransferase 0.0165 0.1173 0.4844
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0125 0.216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0152 0.0152
Echinococcus multilocularis short transient receptor potential channel 6 0.0142 0.0997 0.0994
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0035 0.0161

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.4 uM Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. ChEMBL. No reference
IC50 (functional) = 4.4 uM Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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