Detailed information for compound 163881

Basic information

Technical information
  • TDR Targets ID: 163881
  • Name: N-(4-methoxypyridin-2-yl)-5-phenyl-1,3-thiazo l-2-amine
  • MW: 283.348 | Formula: C15H13N3OS
  • H donors: 1 H acceptors: 2 LogP: 3.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccnc(c1)Nc1ncc(s1)c1ccccc1
  • InChi: 1S/C15H13N3OS/c1-19-12-7-8-16-14(9-12)18-15-17-10-13(20-15)11-5-3-2-4-6-11/h2-10H,1H3,(H,16,17,18)
  • InChiKey: FUZOMJNUEXJFMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-methoxy-2-pyridyl)-5-phenyl-thiazol-2-amine
  • N-(4-methoxy-2-pyridyl)-5-phenyl-2-thiazolamine
  • (4-methoxy-2-pyridyl)-(5-phenylthiazol-2-yl)amine
  • 4-methoxy-N-(5-phenyl-1,3-thiazol-2-yl)pyridin-2-amine
  • 4-methoxy-N-(5-phenylthiazol-2-yl)pyridin-2-amine
  • 4-methoxy-N-(5-phenyl-2-thiazolyl)-2-pyridinamine
  • aminothiazole 17

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0086 0.4289 0.4555
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Echinococcus multilocularis glycoprotein Antigen 5 0.0024 0.0573 0.1337
Loa Loa (eye worm) trypsin family protein 0.0024 0.0573 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Giardia lamblia Cathepsin B precursor 0.0016 0.0109 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0858 0.0814
Echinococcus multilocularis cathepsin L 0.0044 0.1804 0.4205
Brugia malayi Cathepsin L-like precursor 0.0058 0.2595 0.2513
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.2595 0.4608
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.4289 1
Echinococcus multilocularis roundabout 2 0.0018 0.0217 0.0507
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0171
Giardia lamblia Cathepsin B precursor 0.0016 0.0109 0.5
Loa Loa (eye worm) fibroinase 0.0086 0.4289 0.4262
Giardia lamblia Cysteine protease 0.0016 0.0109 0.5
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.4289 1
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.1804 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.4289 0.4262
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Trypanosoma cruzi cruzipain precursor, putative 0.0029 0.0858 0.1791
Leishmania major cathepsin L-like protease 0.0086 0.4289 1
Brugia malayi cathepsin L-like precursor 0.0058 0.2595 0.2513
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0044 0.1804 0.4054
Giardia lamblia Cathepsin B precursor 0.0016 0.0109 0.5
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0029 0.0858 0.0757
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Leishmania major cathepsin L-like protease 0.0086 0.4289 1
Onchocerca volvulus 0.0086 0.4289 0.4555
Toxoplasma gondii cathepsin CPL 0.0086 0.4289 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0109 0.0193
Brugia malayi Cathepsin L-like precursor 0.0029 0.0858 0.0757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0024 0.0573 0.047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4289 1
Trypanosoma cruzi cysteine protease, putative 0.0044 0.1804 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4289 1
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0044 0.1804 0.3203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0573 0.1018
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0044 0.1804 0.3203
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0062
Loa Loa (eye worm) hypothetical protein 0.0109 0.5631 0.561
Echinococcus granulosus cathepsin L cysteine protease 0.0044 0.1804 0.4205
Leishmania major cysteine peptidase A (CPA) 0.0086 0.4289 1
Giardia lamblia Cathepsin B precursor 0.0016 0.0109 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0109 0.0193
Schistosoma mansoni cathepsin C 0.0016 0.0109 0.0193
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0109 0.0193
Onchocerca volvulus 0.0024 0.0573 0.0506
Plasmodium falciparum cysteine proteinase falcipain 1 0.0044 0.1804 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.4289 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.4289 1
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Echinococcus granulosus cathepsin l1 0.0058 0.2595 0.6049
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.1804 0.4054
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.4289 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Onchocerca volvulus 0.0086 0.4289 0.4555
Loa Loa (eye worm) hypothetical protein 0.0058 0.2595 0.256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Onchocerca volvulus 0.0086 0.4289 0.4555
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.1804 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0109 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.5631 0.561
Brugia malayi Cathepsin L-like precursor 0.0086 0.4289 0.4227
Brugia malayi Trypsin family protein 0.0024 0.0573 0.047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Onchocerca volvulus 0.0167 0.9055 0.9748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.1804 0.4054
Schistosoma mansoni hypothetical protein 0.0024 0.0573 0.1018
Onchocerca volvulus Cathepsin L homolog 0.0086 0.4289 0.4555
Brugia malayi Cathepsin L-like precursor 0.0086 0.4289 0.4227
Echinococcus multilocularis cathepsin b 0.0016 0.0109 0.0254
Echinococcus multilocularis Mastin 0.0024 0.0573 0.1337
Plasmodium vivax vivapain-1 0.0044 0.1804 0.4054
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Echinococcus granulosus transmembrane protease serine 3 0.0024 0.0573 0.1337
Loa Loa (eye worm) hypothetical protein 0.0024 0.0573 0.0529
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0062
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.4289 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.2595 0.5946
Echinococcus multilocularis cysteine protease 0.0086 0.4289 1
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.9286 1
Loa Loa (eye worm) ctsf protein 0.0086 0.4289 0.4262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0573 0.1018
Echinococcus granulosus enteropeptidase 0.0024 0.0573 0.1337
Echinococcus granulosus Mastin 0.0024 0.0573 0.1337
Echinococcus multilocularis enteropeptidase 0.0024 0.0573 0.1337
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.1804 0.1713
Onchocerca volvulus 0.0086 0.4289 0.4555
Brugia malayi Trypsin family protein 0.0024 0.0573 0.047
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Loa Loa (eye worm) cysteine protease 0.0086 0.4289 0.4262
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.4289 0.4262
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0171
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0573 0.1337
Giardia lamblia Hypothetical protein 0.0016 0.0109 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0858 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.1804 0.4054
Schistosoma mansoni hypothetical protein 0.0024 0.0573 0.1018
Brugia malayi Cathepsin L-like precursor 0.0058 0.2595 0.2513
Onchocerca volvulus 0.0058 0.2595 0.2709
Brugia malayi Cathepsin L-like cysteine proteinase 0.0058 0.2595 0.2513
Giardia lamblia Cathepsin L precursor 0.0016 0.0109 0.5
Schistosoma mansoni cathepsin s 0.0029 0.0858 0.1523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0109 0.0193
Echinococcus granulosus cathepsin L 0.0044 0.1804 0.4205
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0047 0.011
Onchocerca volvulus 0.0024 0.0573 0.0506
Echinococcus granulosus cathepsin b 0.0016 0.0109 0.0254
Plasmodium vivax vivapain-3 0.0044 0.1804 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.4289 0.7618
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.4289 1
Giardia lamblia Cysteine protease 0.0016 0.0109 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0044 0.1804 0.3203
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0062
Mycobacterium ulcerans hypothetical protein 0.0024 0.0573 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.4289 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0109 0.0193
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0109 0.0193
Onchocerca volvulus 0.0086 0.4289 0.4555
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0109 0.0193
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.2595 0.5946
Echinococcus granulosus glycoprotein Antigen 5 0.0024 0.0573 0.1337
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0573 0.1018
Onchocerca volvulus 0.0109 0.5631 0.6017
Onchocerca volvulus 0.0024 0.0573 0.0506
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.1804 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.4289 1
Echinococcus granulosus cysteine protease 0.0044 0.1804 0.4205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4289 1
Entamoeba histolytica cysteine proteinase 2 0.0044 0.1804 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0109 0.0062
Giardia lamblia Cathepsin L precursor 0.0016 0.0109 0.5
Giardia lamblia Cysteine protease 0.0016 0.0109 0.5
Giardia lamblia Cathepsin L-like protease 0.0016 0.0109 0.5
Giardia lamblia Cathepsin L precursor 0.0016 0.0109 0.5
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0024 0.0573 0.1337
Plasmodium vivax unspecified product 0.0044 0.1804 0.4054
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0109 0.5631 1
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.2595 0.5946
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4289 1
Brugia malayi Trypsin family protein 0.0109 0.5631 0.5583
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.4289 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0016 0.0109 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4289 1
Brugia malayi Trypsin-like protease protein 5 0.0024 0.0573 0.047
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.4289 0.4227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4289 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0573 0.1018
Schistosoma mansoni cathepsin S (C01 family) 0.0016 0.0109 0.0193
Echinococcus granulosus cathepsin b 0.0016 0.0109 0.0254
Giardia lamblia Cathepsin L precursor 0.0016 0.0109 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4289 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0573 0.0529
Giardia lamblia Cathepsin L precursor 0.0016 0.0109 0.5
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0016 0.0109 0.5
Schistosoma mansoni cathepsin B (C01 family) 0.0016 0.0109 0.0193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4289 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0109 0.0062
Entamoeba histolytica cysteine protease, putative 0.0086 0.4289 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0858 0.0814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0016 0.0109 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Leishmania major cathepsin L-like protease 0.0086 0.4289 1
Plasmodium vivax vivapain-2 0.0086 0.4289 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0573 0.0529
Leishmania major cathepsin L-like protease 0.0086 0.4289 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0109 0.5631 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Leishmania major cathepsin L-like protease 0.0086 0.4289 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.4289 1
Brugia malayi hypothetical protein 0.0024 0.0573 0.047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0109 0.0193
Loa Loa (eye worm) hypothetical protein 0.0058 0.2595 0.256
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.1804 0.1713
Brugia malayi Cathepsin L-like precursor 0.0086 0.4289 0.4227
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0024 0.0573 0.1018
Leishmania major cathepsin L-like protease 0.0086 0.4289 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.4289 0.4227
Giardia lamblia Cathepsin B precursor 0.0016 0.0109 0.5
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0016 0.0109 0.0193
Loa Loa (eye worm) hypothetical protein 0.0024 0.0573 0.0529
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.4289 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0016 0.0109 0.0193
Giardia lamblia Hypothetical protein 0.0016 0.0109 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4289 1
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.4289 1
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.4289 0.4262
Echinococcus granulosus roundabout 2 0.0018 0.0217 0.0507
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Plasmodium vivax vivapain-2 0.0086 0.4289 1
Trypanosoma cruzi cysteine proteinase, putative 0.0044 0.1804 0.4054
Giardia lamblia Encystation-specific protease 0.0016 0.0109 0.5
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0024 0.0573 0.1337
Brugia malayi Trypsin family protein 0.0024 0.0573 0.047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.1804 0.4054
Brugia malayi Cathepsin L-like precursor 0.0086 0.4289 0.4227
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.0858 0.0757
Echinococcus multilocularis cathepsin b 0.0016 0.0109 0.0254
Onchocerca volvulus 0.0024 0.0573 0.0506
Schistosoma mansoni cell adhesion molecule 0.0015 0.0047 0.0084
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0016 0.0109 0.0193
Echinococcus granulosus cathepsin l1 0.0086 0.4289 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Echinococcus multilocularis cathepsin L 0.0016 0.0109 0.0254
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0016 0.0109 0.0193
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0016 0.0109 0.5
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Giardia lamblia Cathepsin L precursor 0.0016 0.0109 0.5
Plasmodium vivax unspecified product 0.0029 0.0858 0.1791
Giardia lamblia Cysteine protease 0.0016 0.0109 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Onchocerca volvulus 0.0085 0.422 0.448
Echinococcus multilocularis cysteine protease 0.0086 0.4289 1
Giardia lamblia Cathepsin L-like protease 0.0016 0.0109 0.5
Onchocerca volvulus 0.0086 0.4289 0.4555
Trypanosoma cruzi cysteine proteinase, putative 0.0044 0.1804 0.4054
Giardia lamblia Cathepsin B precursor 0.0016 0.0109 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.0573 0.1018
Onchocerca volvulus Cathepsin L homolog 0.0086 0.4289 0.4555
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4289 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.2595 0.256
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0024 0.0573 0.1337
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.1804 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.4289 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Echinococcus multilocularis transmembrane protease serine 3 0.0024 0.0573 0.1337
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0858 0.1791
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0062
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0016 0.0109 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4289 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4289 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4289 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Onchocerca volvulus Cathepsin F homolog 0.0086 0.4289 0.4555
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Loa Loa (eye worm) cathepsin B 0.0016 0.0109 0.0062
Onchocerca volvulus 0.0024 0.0573 0.0506
Schistosoma mansoni cercarial elastase (S01 family) 0.0024 0.0573 0.1018
Brugia malayi Cathepsin L-like precursor 0.0086 0.4289 0.4227
Leishmania major cathepsin L-like protease 0.0086 0.4289 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0044 0.1804 0.4054
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.0573 0.0529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4289 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Leishmania major cathepsin L-like protease 0.0086 0.4289 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0858 0.0814
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.1804 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.2595 0.5946
Entamoeba histolytica cysteine protease, putative 0.0044 0.1804 0.4054
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0016 0.0109 0.0062
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.4289 0.7618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4289 1
Echinococcus granulosus cathepsin L 0.0016 0.0109 0.0254
Giardia lamblia Cathepsin B precursor 0.0016 0.0109 0.5
Giardia lamblia Cathepsin B precursor 0.0016 0.0109 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 11 nM Inhibitory activity towards vascular endothelial growth factor receptor 2 ChEMBL. 15125964
IC50 (binding) = 11 nM Inhibitory activity towards vascular endothelial growth factor receptor 2 ChEMBL. 15125964

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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