Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.036 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0516 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0516 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0516 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0516 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0516 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0516 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0516 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.036 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0516 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.