Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glucocorticoid receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (ADMET) | = 70 % | Transactivation activity at glucocorticoid receptor in human HepG2 cells assessed as induction of tyrosine aminotransferase relative to control | ChEMBL. | 22465636 |
Efficacy (ADMET) | = 96 % | Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as induction of tyrosine aminotransferase relative to control | ChEMBL. | 22465636 |
Efficacy (binding) | = 100 % | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-induced IL8 production relative to control | ChEMBL. | 22465636 |
IC50 (binding) | = 0.63 nM | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-induced IL8 production | ChEMBL. | 22465636 |
IC50 (ADMET) | = 3.23 nM | Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as induction of tyrosine aminotransferase | ChEMBL. | 22465636 |
IC50 (ADMET) | = 143 nM | Transactivation activity at glucocorticoid receptor in human HepG2 cells assessed as induction of tyrosine aminotransferase | ChEMBL. | 22465636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.