Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | folate/biopterin transporter, putative | 0.0114 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.1095 | 0.2609 | 0.2127 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.2101 | 0.5282 | 0.3617 |
Entamoeba histolytica | protein kinase 2, putative | 0.2125 | 0.5345 | 0.6338 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.3287 | 0.8433 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.2125 | 0.5345 | 0.3702 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.1095 | 0.2609 | 0.2127 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.2215 | 0.5585 | 0.5965 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.2125 | 0.5345 | 0.3702 |
Entamoeba histolytica | protein kinase, putative | 0.1095 | 0.2609 | 0.3094 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1095 | 0.2609 | 0.2063 |
Echinococcus multilocularis | nervana 2 | 0.2101 | 0.5282 | 0.3617 |
Brugia malayi | Protein kinase domain containing protein | 0.1095 | 0.2609 | 0.2127 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.2215 | 0.5585 | 0.6622 |
Leishmania major | protein kinase, putative | 0.0114 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.1095 | 0.2609 | 0.2127 |
Entamoeba histolytica | kinesin, putative | 0.0504 | 0.1036 | 0.1228 |
Trypanosoma cruzi | Protein kinase B | 0.2215 | 0.5585 | 1 |
Plasmodium vivax | kinesin-5 | 0.0504 | 0.1036 | 0.1938 |
Toxoplasma gondii | AGC kinase | 0.3197 | 0.8194 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.1095 | 0.2609 | 0.2063 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1095 | 0.2609 | 0.2063 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.2125 | 0.5345 | 0.3702 |
Echinococcus granulosus | nervana 2 | 0.2101 | 0.5282 | 0.3617 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1095 | 0.2609 | 0.2063 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.3197 | 0.8194 | 0.9676 |
Entamoeba histolytica | protein kinase, putative | 0.3287 | 0.8433 | 1 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0114 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.3287 | 0.8433 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.2215 | 0.5585 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.3287 | 0.8433 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.2125 | 0.5345 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.3287 | 0.8433 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1186 | 0.2849 | 0.3378 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.1095 | 0.2609 | 0.2127 |
Schistosoma mansoni | atypical protein kinase C | 0.1095 | 0.2609 | 0.2063 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.2125 | 0.5345 | 0.9571 |
Trichomonas vaginalis | AGC family protein kinase | 0.1095 | 0.2609 | 0.3094 |
Brugia malayi | Protein kinase domain containing protein | 0.3287 | 0.8433 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.1095 | 0.2609 | 0.2127 |
Echinococcus granulosus | nervana 2 | 0.2101 | 0.5282 | 0.3617 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.2101 | 0.5282 | 0.3617 |
Loa Loa (eye worm) | hypothetical protein | 0.1095 | 0.2609 | 0.2127 |
Schistosoma mansoni | hypothetical protein | 0.3373 | 0.8662 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.1095 | 0.2609 | 0.2127 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1095 | 0.2609 | 0.2063 |
Brugia malayi | protein kinase C II. | 0.1095 | 0.2609 | 0.2127 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.1072 | 0.2546 | 0.3019 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.2125 | 0.5345 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.2215 | 0.5585 | 0.4026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1095 | 0.2609 | 0.2063 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.3197 | 0.8194 | 0.9676 |
Echinococcus granulosus | serine/threonine protein kinase | 0.2215 | 0.5585 | 0.4026 |
Plasmodium falciparum | kinesin-5 | 0.0504 | 0.1036 | 0.1938 |
Entamoeba histolytica | protein kinase, putative | 0.3197 | 0.8194 | 0.9716 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1095 | 0.2609 | 0.2063 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0114 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.3876 | 1 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.1095 | 0.2609 | 0.2127 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.2101 | 0.5282 | 0.3617 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.2215 | 0.5585 | 0.6622 |
Echinococcus multilocularis | nervana 2 | 0.2101 | 0.5282 | 0.3617 |
Giardia lamblia | Kinase, AGC PKA | 0.2125 | 0.5345 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0504 | 0.1036 | 0.1264 |
Leishmania major | protein kinase, putative | 0.0114 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.3287 | 0.8433 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1095 | 0.2609 | 0.3094 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1095 | 0.2609 | 0.2063 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.1095 | 0.2609 | 0.2127 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0114 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.2215 | 0.5585 | 0.5965 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.2101 | 0.5282 | 0.3617 |
Trichomonas vaginalis | AGC family protein kinase | 0.3287 | 0.8433 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.3287 | 0.8433 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.3287 | 0.8433 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.3287 | 0.8433 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.3287 | 0.8433 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1095 | 0.2609 | 0.3094 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (binding) | < 15 % | Inhibition of human SERT-mediated serotonin reuptake in HEK293 cells at 100 nM relative to fluoxetine | ChEMBL. | 21927645 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.