Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.164 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.1617 | 0.9795 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.164 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.164 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1617 | 0.9795 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.11 | 0.5195 | 0.5392 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.164 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.164 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1617 | 0.9795 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1494 | 0.8695 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.164 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.164 | 1 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.119 | 0.5993 | 0.8166 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.1314 | 0.7093 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.1314 | 0.7093 | 0.7241 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.