Detailed information for compound 1639710

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2007.36 | Formula: C44H57Na11O55S9
  • H donors: 11 H acceptors: 31 LogP: -9.15 Rotable bonds: 41
    Rule of 5 violations (Lipinski): 3
  • SMILES: CO[C@@H]1[C@@H](OC)[C@H](O[C@@H]2[C@@H](COS(=O)(=O)[O-])O[C@H]([C@@H]([C@H]2OS(=O)(=O)[O-])OS(=O)(=O)[O-])O[C@@H]2[C@@H](O[C@H]([C@@H]([C@H]2OCCCc2ccccc2)OS(=O)(=O)[O-])O[C@@H]2[C@@H](COS(=O)(=O)[O-])O[C@@H]([C@@H]([C@H]2OS(=O)(=O)[O-])OS(=O)(=O)[O-])OC)C(=O)[O-])O[C@@H]([C@H]1O[C@@H]1O[C@H](COS(=O)(=O)[O-])[C@H]([C@@H]([C@H]1OS(=O)(=O)[O-])OC)OC)C(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
  • InChi: 1S/C44H68O55S9.11Na/c1-76-21-18(14-82-100(49,50)51)86-42(34(24(21)77-2)96-105(64,65)66)90-27-25(78-3)33(79-4)41(92-31(27)38(45)46)88-23-20(16-84-102(55,56)57)87-43(37(99-108(73,74)75)30(23)95-104(61,62)63)91-28-26(81-13-9-12-17-10-7-6-8-11-17)35(97-106(67,68)69)44(93-32(28)39(47)48)89-22-19(15-83-101(52,53)54)85-40(80-5)36(98-107(70,71)72)29(22)94-103(58,59)60;;;;;;;;;;;/h6-8,10-11,18-37,40-44H,9,12-16H2,1-5H3,(H,45,46)(H,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)(H,70,71,72)(H,73,74,75);;;;;;;;;;;/q;11*+1/p-11/t18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32-,33-,34-,35-,36-,37-,40+,41-,42+,43+,44-;;;;;;;;;;;/m1.........../s1
  • InChiKey: GKUMMYBOHBACOV-XRQGFQKASA-C  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Onchocerca volvulus 0.0028 0.0589 0.063
Onchocerca volvulus 0.0028 0.0589 0.063
Schistosoma mansoni hypothetical protein 0.0028 0.0589 0.1026
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.0589 0.0589
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0317 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.0589 0.1026
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0317 0.0543
Loa Loa (eye worm) hypothetical protein 0.0013 0.0182 0.0182
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0589 0.1011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0317 0.0543
Onchocerca volvulus 0.0028 0.0589 0.063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0317 0.0543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0589 0.1026
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0317 0.0317
Echinococcus granulosus g protein coupled receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0317
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0589 0.1011
Trypanosoma brucei C-8 sterol isomerase, putative 0.0359 1 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.0589 0.1011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0028 0.0589 0.063
Brugia malayi AKH receptor 0.0028 0.0589 0.0589
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.0589 0.0589
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0589 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0589 0.1026
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0317 0.0551
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.0589 0.1026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0589 0.1026
Onchocerca volvulus 0.0028 0.0589 0.063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0589 0.1026
Schistosoma mansoni neuropeptide receptor 0.0028 0.0589 0.1026
Onchocerca volvulus 0.0028 0.0589 0.063
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0317 0.0543
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0589 0.1011
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Onchocerca volvulus 0.0028 0.0589 0.063
Brugia malayi ORL1-like opioid receptor 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.0589 0.0589
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.0589 0.1011
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0317 0.0543
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0182 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0317
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.0589 0.1011
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0589 0.1011
Schistosoma mansoni amine GPCR 0.0028 0.0589 0.1026
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.0589 0.1011
Echinococcus multilocularis serotonin receptor 0.0028 0.0589 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0317 0.0317
Echinococcus multilocularis allatostatin A receptor 0.0028 0.0589 0.1011
Onchocerca volvulus 0.0028 0.0589 0.063
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0317 0.0551
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.0589 0.1026
Schistosoma mansoni neuropeptide receptor 0.0028 0.0589 0.1026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0317 0.0317
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.0589 0.1026
Schistosoma mansoni neuropeptide receptor 0.0028 0.0589 0.1026
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.0589 0.1011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0317 0.0551
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0359 1 0.5
Brugia malayi larval opioid receptor 0.0028 0.0589 0.0589
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0589 0.1011
Brugia malayi sulfakinin receptor protein 0.0028 0.0589 0.0589
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.0589 0.1011
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.0589 0.1011
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0171 0.4647 0.4647
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.0589 0.1011
Schistosoma mansoni opsin-like receptor 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Schistosoma mansoni amine GPCR 0.0028 0.0589 0.1026
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0317 0.0543
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0317 0.0543
Echinococcus multilocularis tyrosine protein kinase Abl 0.0087 0.2262 0.3879
Echinococcus granulosus g protein coupled receptor 0.0028 0.0589 0.1011
Brugia malayi Melatonin receptor type 1A 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus tyrosine protein kinase ABL1 0.0212 0.5831 1
Echinococcus granulosus g protein coupled receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.0589 0.1026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0317 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Onchocerca volvulus 0.0028 0.0589 0.063
Echinococcus multilocularis orexin receptor type 2 0.0028 0.0589 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0317 0.0317
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0589 0.1011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0589 0.1026
Schistosoma mansoni myosin xvIII 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0589 0.1011
Schistosoma mansoni adenoreceptor 0.0028 0.0589 0.1026
Brugia malayi steroid hormone receptor 0.0018 0.0317 0.0317
Brugia malayi follicle stimulating hormone receptor 0.0028 0.0589 0.0589
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0317 0.0551
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0589 0.0589
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0589 0.0589
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi GnHR receptor homolog 0.0028 0.0589 0.0589
Echinococcus multilocularis sex peptide receptor 0.0028 0.0589 0.1011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0317 0.0543
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0317 0.0551
Echinococcus multilocularis serotonin receptor 0.0028 0.0589 0.1011
Echinococcus granulosus neuropeptide receptor A26 0.0028 0.0589 0.1011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.0589 0.0589
Schistosoma mansoni hypothetical protein 0.0028 0.0589 0.1026
Schistosoma mansoni amine GPCR 0.0028 0.0589 0.1026
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus orexin receptor type 2 0.0028 0.0589 0.1011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Brugia malayi RE15519p 0.0028 0.0589 0.0589
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.0589 0.0589
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.0589 0.1011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0317 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0589 0.1026
Leishmania major C-8 sterol isomerase-like protein 0.0359 1 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0589 0.0589
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0317 0.0551
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0028 0.0589 0.1026
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.0589 0.1026
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0182 0.0312
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0317 0.0543
Loa Loa (eye worm) hypothetical protein 0.0013 0.0182 0.0182
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.0589 0.1011
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.0589 0.1026
Schistosoma mansoni hypothetical protein 0.0028 0.0589 0.1026
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0182 0.0312
Onchocerca volvulus 0.0028 0.0589 0.063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0589 0.1011
Brugia malayi neuropeptide F receptor 0.0028 0.0589 0.0589
Echinococcus granulosus allatostatin A receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0184 0.5016 0.5016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0589 0.1026
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0589 0.1011
Brugia malayi putative neuropeptide receptor 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) TK/ABL protein kinase 0.0212 0.5831 0.5831
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0589 0.1026
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0317 0.0551
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi nuclear hormone receptor 0.0018 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.0589 0.1011
Echinococcus granulosus serotonin receptor 0.0028 0.0589 0.1011
Echinococcus multilocularis neuropeptide s receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.0589 0.1011
Brugia malayi Tyrosine-protein kinase abl-1 0.0087 0.2262 0.2262
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.0589 0.0589
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.0589 0.0589
Schistosoma mansoni amine GPCR 0.0028 0.0589 0.1026
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0589 0.1011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0317 0.0317
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.0589 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus sex peptide receptor 0.0028 0.0589 0.1011
Schistosoma mansoni coup transcription factor 0.0018 0.0317 0.0551
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0317 0.0543
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Onchocerca volvulus 0.0028 0.0589 0.063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.0589 0.0589
Onchocerca volvulus 0.0028 0.0589 0.063
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0317 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0317 0.0317
Onchocerca volvulus 0.0028 0.0589 0.063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0013 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0317 0.0543
Echinococcus multilocularis neuropeptide receptor A26 0.0028 0.0589 0.1011
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0317 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0317 0.0317
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0589 0.1011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0589 0.1026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0317 0.0551
Brugia malayi hypothetical protein 0.0013 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0317
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.0589 0.1011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0317 0.0543
Onchocerca volvulus 0.0028 0.0589 0.063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi G-protein coupled receptor 0.0028 0.0589 0.0589
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0589 0.0589
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0589 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0589 0.1026
Brugia malayi Dopamine receptor protein 1 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0212 0.5831 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi ecdysteroid receptor 0.0171 0.4647 0.4647
Brugia malayi Serotonin receptor 0.0028 0.0589 0.0589
Echinococcus multilocularis somatostatin receptor 0.0028 0.0589 0.1011
Brugia malayi Dopamine receptor protein 2 0.0028 0.0589 0.0589
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0317 0.0317
Brugia malayi hypothetical protein 0.0013 0.0182 0.0182
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.0589 0.1011
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0081 0.2091 0.2091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0317 0.0317
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0589 0.1026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0317 0.0317
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0589 0.1011
Echinococcus granulosus neuropeptide receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.0589 0.0589
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0589 0.1011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.0589 0.1011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0317 0.0543
Brugia malayi Serotonin receptor 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0589 0.1011
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0317
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0317 0.0543
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0182 0.0182
Schistosoma mansoni neuropeptide receptor 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.0589 0.1011
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.0589 0.1026
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0182 0.0182
Schistosoma mansoni opsin-like receptor 0.0028 0.0589 0.1026
Schistosoma mansoni opsin-like receptor 0.0028 0.0589 0.1026
Schistosoma mansoni biogenic amine receptor 0.0028 0.0589 0.1026
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.0589 0.0589
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.0589 0.1026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0589 0.1011
Onchocerca volvulus 0.0028 0.0589 0.063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0317 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus neuropeptide receptor 0.0028 0.0589 0.1011
Onchocerca volvulus 0.0028 0.0589 0.063
Onchocerca volvulus Neuropeptide F receptor homolog 0.0028 0.0589 0.063
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0317 0.0317
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.0589 0.0589
Brugia malayi nuclear receptor NHR-88 0.0018 0.0317 0.0317
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0589 0.1011
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.0589 0.1011
Schistosoma mansoni biogenic amine receptor 0.0028 0.0589 0.1026
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus hypothetical protein 0.0028 0.0589 0.1011
Brugia malayi G-protein coupled receptor 0.0028 0.0589 0.0589
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus g-protein coupled receptor 0.0028 0.0589 0.1011
Echinococcus granulosus fmrfamide receptor 0.0028 0.0589 0.1011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0317 0.0317
Brugia malayi neuropeptide F receptor 0.0028 0.0589 0.0589
Onchocerca volvulus Bile acid receptor homolog 0.0171 0.4647 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.0589 0.1011
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0589 0.1011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0317 0.0543
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0589 0.1011
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0182 0.0317
Schistosoma mansoni tyrosine kinase 0.0209 0.5745 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0317 0.0543
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0317 0.0317
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0317 0.0551
Schistosoma mansoni amine GPCR 0.0028 0.0589 0.1026
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0589 0.1011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0317 0.0543
Schistosoma mansoni biogenic amine receptor 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0182 0.0182
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0589 0.1011
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.0589 0.1011
Schistosoma mansoni histamine h1 receptor 0.0028 0.0589 0.1026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0589 0.1026
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0589 0.1011
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0317 0.0317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0317 0.0317
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.0589 0.1026
Onchocerca volvulus 0.0028 0.0589 0.063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Onchocerca volvulus 0.0028 0.0589 0.063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0317 0.0317
Brugia malayi hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi Tyrosine-protein kinase abl-1 0.0129 0.3459 0.3459
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0317 0.0551
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0317 0.0551
Loa Loa (eye worm) hypothetical protein 0.0359 1 1
Echinococcus granulosus somatostatin receptor 0.0028 0.0589 0.1011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.0589 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0589 0.1011
Brugia malayi Dopamine receptor 0.0028 0.0589 0.0589
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0589 0.1026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Brugia malayi G protein-coupled receptor 0.0028 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0589 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Echinococcus granulosus neuropeptide s receptor 0.0028 0.0589 0.1011
Brugia malayi nuclear receptor RXR 0.0013 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0589 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0317 0.0317

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 434 U mg-1 Compound was evaluated for the inhibition of anti-thrombin III (AT III)-mediated coagulation proteinase factor Xa ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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