Detailed information for compound 163991

Basic information

Technical information
  • TDR Targets ID: 163991
  • Name: 5-phenyl-N-pyridin-2-yl-1,3-thiazol-2-amine
  • MW: 253.322 | Formula: C14H11N3S
  • H donors: 1 H acceptors: 2 LogP: 3.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(nc1)Nc1ncc(s1)c1ccccc1
  • InChi: 1S/C14H11N3S/c1-2-6-11(7-3-1)12-10-16-14(18-12)17-13-8-4-5-9-15-13/h1-10H,(H,15,16,17)
  • InChiKey: YBTSWXCHAPCPGJ-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 5-phenyl-N-(2-pyridyl)thiazol-2-amine
  • 5-phenyl-N-(2-pyridyl)-2-thiazolamine
  • (5-phenylthiazol-2-yl)-(2-pyridyl)amine
  • N-(5-phenyl-1,3-thiazol-2-yl)pyridin-2-amine
  • N-(5-phenylthiazol-2-yl)pyridin-2-amine
  • N-(5-phenyl-2-thiazolyl)-2-pyridinamine
  • N-(1,3-Thiazol-2-yl)pyridin-2-amine 1

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.0267 0.131
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0099 0.0138
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0034 0.0139
Mycobacterium ulcerans thioesterase 0.0023 0.008 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0134 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0134 0.0651
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0899 0.4438
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0034 0.0156
Brugia malayi tailless protein 0.0014 0.0023 0.0104
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0094 0.0063
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0057 0.0027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0134 0.1194
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0023 0.0104
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0034 0.5
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0034 0.0287
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0109 0.0528
Loa Loa (eye worm) hypothetical protein 0.0043 0.0221 0.1083
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0134 0.1194
Onchocerca volvulus 0.0047 0.0249 0.1133
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0094 0.0454
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0023 0.0093
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0285
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0116 0.0565
Echinococcus granulosus neuroglian 0.0014 0.0022 0.0088
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0059 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0134 0.0651
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0411 0.2765 0.3835
Onchocerca volvulus Dual oxidase homolog 0.0028 0.0116 0.0465
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0134 0.0582
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0134 0.0582
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0116 0.0565
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0214 0.0925
Brugia malayi hypothetical protein 0.0014 0.0023 0.0104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0234 0.1149
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1047 0.716 1
Schistosoma mansoni peroxidasin 0.0031 0.0141 0.1265
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.1984 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Onchocerca volvulus 0.0167 0.1077 0.5273
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0116 0.0565
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0134 0.1194
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Mycobacterium ulcerans polyketide synthase 0.0026 0.0105 0.0075
Toxoplasma gondii hypothetical protein 0.0048 0.0257 0.0866
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.0261 0.1283
Schistosoma mansoni nuclear receptor 0.0014 0.0023 0.0191
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0134 0.0582
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.016 0.0783
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0898 0.1254
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0134 0.1194
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0054
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0234 0.1149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0134 0.0651
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0134 0.0582
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.1984 1
Echinococcus granulosus FTZ F1 alpha 0.003 0.0134 0.0582
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0094 0.0063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.1187 0.5868
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0034 0.0139
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0023 0.0093
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0035 0.0298
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1458 1 0.5
Echinococcus granulosus peroxidasin 0.0034 0.0161 0.0704
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1458 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Schistosoma mansoni nuclear receptor 0.0014 0.0023 0.0191
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0027 0.0112
Schistosoma mansoni hypothetical protein 0.0171 0.1103 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.008 0.0069
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0285
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Brugia malayi nuclear receptor RXR 0.0016 0.0035 0.0163
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.014
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0214 0.0925
Brugia malayi nuclear receptor RXR 0.0014 0.0023 0.0104
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0136 0.0663
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Brugia malayi isocitrate dehydrogenase 0.0016 0.0034 0.0157
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0023 0.0093
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0269 0.1323
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0134 0.0651
Brugia malayi ecdysteroid receptor 0.003 0.0134 0.0651
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0094 0.0131
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0023 0.0191
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.1103 0.5408
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0035 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0134 0.0651
Echinococcus granulosus twitchin 0.0014 0.0022 0.0088
Onchocerca volvulus Peroxidase homolog 0.0028 0.0116 0.0465
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0134 0.0651
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0116 0.0565
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0094 0.0063
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0034 0.014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0094 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0134 0.0651
Schistosoma mansoni hypothetical protein 0.0171 0.1103 1
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0136 0.0663
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0057 0.0038
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0094 0.0131
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0116 0.0565
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0898 0.087
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0116 0.0565
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0023 0.0104
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0023 0.0104
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0023 0.0104
Schistosoma mansoni thyroid hormone receptor 0.003 0.0134 0.1194
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Loa Loa (eye worm) blistered cuticle protein 3 0.0028 0.0116 0.0565
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0023 0.0093
Schistosoma mansoni zinc finger protein 0.0014 0.0023 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0134 0.0582
Onchocerca volvulus Peroxidase homolog 0.0028 0.0116 0.0465
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.014
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0023 0.0093
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0285
Onchocerca volvulus Peroxidasin homolog 0.0031 0.0136 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0134 0.0582
Echinococcus granulosus tumor protein p63 0.0338 0.2261 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0156
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0023 0.0104
Onchocerca volvulus 0.0028 0.0116 0.0465
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0023 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0134 0.0651
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0034 0.0156
Mycobacterium ulcerans hypothetical protein 0.0157 0.1009 0.0982
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0034 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0234 0.2106
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0023 0.0093
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0099 0.048
Loa Loa (eye worm) hypothetical protein 0.005 0.0269 0.1323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0234 0.1026
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0134 0.0651
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0023 0.0093
Brugia malayi Pax transcription factor protein 2 0.0241 0.1589 0.7862
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.0261 0.1191
Mycobacterium ulcerans polyketide synthase 0.0025 0.0094 0.0063
Echinococcus granulosus roundabout 2 0.0018 0.0047 0.02
Echinococcus multilocularis roundabout 2 0.0018 0.0047 0.02
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0214 0.0925
Schistosoma mansoni thyroid hormone receptor 0.003 0.0134 0.1194
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0134 0.0651
Schistosoma mansoni nephrin 0.0014 0.0022 0.018
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0105 0.0147
Onchocerca volvulus 0.0025 0.0099 0.038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0134 0.0582
Brugia malayi nuclear hormone receptor 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0899 0.4438
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0034 0.014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0224
Loa Loa (eye worm) pax transcription factor protein 2 0.0241 0.1589 0.7862
Schistosoma mansoni hypothetical protein 0.0034 0.016 0.1435
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0134 0.1194
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0034 0.0157
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0134 0.1194
Loa Loa (eye worm) acyl carrier protein 0.0012 0.001 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0234 0.2106
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0034 0.0047
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0023 0.0191
Echinococcus multilocularis neuroglian 0.0014 0.0022 0.0088
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0105 0.0147
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.008 0.0112
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1047 0.716 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0411 0.2765 0.2743
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0134 0.0582
Brugia malayi hypothetical protein 0.0303 0.2021 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0234 0.1026
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0134 0.0582
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0134 0.1194
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0277 0.1249
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0134 0.0582
Onchocerca volvulus 0.0241 0.1589 0.7839
Brugia malayi hypothetical protein 0.0016 0.0035 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0234 0.1026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0134 0.0582
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0094 0.0089
Brugia malayi conserved hypotetical protein 0.0014 0.0023 0.0104
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0186 0.026
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0023 0.0093
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0034 0.5
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0134 0.0553
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0134 0.0553
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0186 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0134 0.0651
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0023 0.0191
Onchocerca volvulus 0.0028 0.0116 0.0465
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0035 0.0163
Onchocerca volvulus 0.0028 0.0116 0.0465
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0023 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0134 0.0651
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1009 0.141
Brugia malayi nuclear receptor NHR-88 0.0014 0.0023 0.0104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0134 0.0582
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0134 0.0651
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0023 0.0191
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0105 0.0075
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0035 0.0298
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0105 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0134 0.0651
Echinococcus multilocularis geminin 0.0171 0.1103 0.4873
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0105 0.0075
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0023 0.0191
Mycobacterium ulcerans thioesterase TesA 0.0023 0.008 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0134 0.0582
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0269 0.1323
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.014
Loa Loa (eye worm) DR-78 0.0014 0.0023 0.0104
Schistosoma mansoni coup transcription factor 0.003 0.0134 0.1194
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0214 0.0925
Schistosoma mansoni cell adhesion molecule 0.0015 0.0027 0.023
Brugia malayi nuclear receptor NHR-88 0.003 0.0134 0.0651
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0134 0.1194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0134 0.0582
Loa Loa (eye worm) hypothetical protein 0.0303 0.2021 1
Echinococcus multilocularis tumor protein p63 0.0338 0.2261 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0105 0.0105
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0105 0.0147
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Brugia malayi steroid hormone receptor 0.003 0.0134 0.0651
Brugia malayi nuclear hormone receptor 0.003 0.0134 0.0651
Brugia malayi nuclear receptor NHR-67 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0224
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0105 0.0315
Echinococcus multilocularis GPCR, family 2 0.0016 0.0034 0.0139
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0048
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0234 0.1026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0134 0.0582
Brugia malayi hypothetical protein 0.0028 0.0116 0.0565
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0035 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0035 0.0145
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.1917 0.5
Onchocerca volvulus Chorion peroxidase homolog 0.0028 0.0116 0.0465
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0411 0.2765 1
Brugia malayi Peroxidasin 0.0034 0.0161 0.0788
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0023 0.0093
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0023 0.0104
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0186 0.026
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0134 0.0651
Schistosoma mansoni nuclear hormone receptor 0.003 0.0134 0.1194
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0046 0.0097
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0023 0.0093
Brugia malayi Blistered cuticle protein 3 0.0028 0.0116 0.0565
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0057 0.0027
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0057 0.014
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0285
Onchocerca volvulus 0.0049 0.0267 0.1219
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0105 0.0105
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1984 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0134 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0134 0.0651
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0134 0.0582
Onchocerca volvulus Peroxidasin homolog 0.0031 0.0136 0.0565
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0234 0.2106
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0035 0.0163
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0034 0.0139
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0105 0.0147
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0267 0.2401
Echinococcus granulosus GPCR family 2 0.0016 0.0034 0.0139
Loa Loa (eye worm) hypothetical protein 0.0034 0.016 0.0783
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0134 0.0582
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1984 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.006 0.0084
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0134 0.1194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0116 0.0565
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Schistosoma mansoni peroxidasin 0.0028 0.0116 0.1035
Brugia malayi hypothetical protein 0.0014 0.0023 0.0104
Brugia malayi hypothetical protein 0.0016 0.0035 0.0163
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0105 0.0105
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0186 0.0156
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.1187 0.5868
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0099 0.048
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0134 0.0553
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0023 0.0093
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0898 0.1217
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0788
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0269 0.1323
Echinococcus granulosus geminin 0.0171 0.1103 0.4873
Echinococcus multilocularis peroxidasin 0.0034 0.0161 0.0704
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0094 0.0131
Brugia malayi ecdysone receptor 0.0014 0.0023 0.0104
Onchocerca volvulus 0.0303 0.2021 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0094 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0134 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0134 0.0651
Onchocerca volvulus 0.003 0.0134 0.0553
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0134 0.0651
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0034 0.0139
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1458 1 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0034 0.0156
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0899 0.4438

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7 nM Inhibitory activity towards vascular endothelial growth factor receptor 2 ChEMBL. 15125964
IC50 (binding) = 7 nM Inhibitory activity towards vascular endothelial growth factor receptor 2 ChEMBL. 15125964
Selectivity (binding) = 51 Selectivity for Fibroblast growth factor receptor 2 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 164 Selectivity for Fibroblast growth factor receptor 1 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 280 Selectivity for Src protein tryrosine kinase over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 0.3 Selectivity for PDGFRbeta over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 2 Selectivity for Vascular endothelial growth factor receptor 3 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 3 Selectivity for Vascular endothelial growth factor receptor 1 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 51 Selectivity for Fibroblast growth factor receptor 2 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 164 Selectivity for Fibroblast growth factor receptor 1 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 280 Selectivity for Src protein tryrosine kinase over (KDR) kinase insert domain receptor ChEMBL. 15125964

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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