Detailed information for compound 163991

Basic information

Technical information
  • TDR Targets ID: 163991
  • Name: 5-phenyl-N-pyridin-2-yl-1,3-thiazol-2-amine
  • MW: 253.322 | Formula: C14H11N3S
  • H donors: 1 H acceptors: 2 LogP: 3.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(nc1)Nc1ncc(s1)c1ccccc1
  • InChi: 1S/C14H11N3S/c1-2-6-11(7-3-1)12-10-16-14(18-12)17-13-8-4-5-9-15-13/h1-10H,(H,15,16,17)
  • InChiKey: YBTSWXCHAPCPGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-phenyl-N-(2-pyridyl)thiazol-2-amine
  • 5-phenyl-N-(2-pyridyl)-2-thiazolamine
  • (5-phenylthiazol-2-yl)-(2-pyridyl)amine
  • N-(5-phenyl-1,3-thiazol-2-yl)pyridin-2-amine
  • N-(5-phenylthiazol-2-yl)pyridin-2-amine
  • N-(5-phenyl-2-thiazolyl)-2-pyridinamine
  • N-(1,3-Thiazol-2-yl)pyridin-2-amine 1

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0057 0.0027
Onchocerca volvulus 0.0049 0.0267 0.1219
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0094 0.0063
Onchocerca volvulus Chorion peroxidase homolog 0.0028 0.0116 0.0465
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0899 0.4438
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0134 0.1194
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0134 0.1194
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0105 0.0147
Loa Loa (eye worm) pax transcription factor protein 2 0.0241 0.1589 0.7862
Echinococcus multilocularis neuroglian 0.0014 0.0022 0.0088
Brugia malayi nuclear receptor NHR-88 0.0014 0.0023 0.0104
Mycobacterium ulcerans polyketide synthase 0.0026 0.0105 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0234 0.1026
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0034 0.0157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Brugia malayi Animal haem peroxidase family protein 0.0031 0.0136 0.0663
Onchocerca volvulus 0.003 0.0134 0.0553
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0134 0.0582
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.014
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0116 0.0565
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0034 0.0139
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0023 0.0093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0134 0.0651
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1458 1 0.5
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0034 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0059 0.0082
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0023 0.0104
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0023 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0134 0.0651
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0023 0.0093
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.0261 0.1283
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Echinococcus granulosus geminin 0.0171 0.1103 0.4873
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0023 0.0104
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0027 0.0112
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0109 0.0528
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0057 0.0027
Onchocerca volvulus Peroxidasin homolog 0.0031 0.0136 0.0565
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0116 0.0565
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0105 0.0105
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0134 0.0651
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0105 0.0075
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Brugia malayi nuclear receptor NHR-88 0.003 0.0134 0.0651
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.014
Brugia malayi nuclear hormone receptor 0.0014 0.0023 0.0104
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Schistosoma mansoni zinc finger protein 0.0014 0.0023 0.0191
Brugia malayi nuclear receptor NHR-67 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0035 0.0145
Echinococcus multilocularis roundabout 2 0.0018 0.0047 0.02
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0269 0.1323
Brugia malayi hypothetical protein 0.0303 0.2021 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0134 0.0651
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.008 0.0112
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0023 0.0104
Onchocerca volvulus 0.0028 0.0116 0.0465
Echinococcus multilocularis peroxidasin 0.0034 0.0161 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0134 0.0651
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0234 0.2106
Echinococcus multilocularis geminin 0.0171 0.1103 0.4873
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0023 0.0104
Brugia malayi nuclear receptor RXR 0.0014 0.0023 0.0104
Onchocerca volvulus 0.0028 0.0116 0.0465
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0224
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0134 0.0651
Echinococcus granulosus neuroglian 0.0014 0.0022 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0186 0.026
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0105 0.0147
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0023 0.0104
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0186 0.0156
Brugia malayi nuclear receptor RXR 0.0016 0.0035 0.0163
Brugia malayi Peroxidasin 0.0034 0.0161 0.0788
Loa Loa (eye worm) hypothetical protein 0.0043 0.0221 0.1083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0134 0.0651
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.1187 0.5868
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0898 0.1254
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0234 0.1026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0285
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0034 0.0156
Brugia malayi ecdysone receptor 0.0014 0.0023 0.0104
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0034 0.014
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0285
Brugia malayi conserved hypotetical protein 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0116 0.0565
Loa Loa (eye worm) hypothetical protein 0.0049 0.0267 0.131
Echinococcus granulosus peroxidasin 0.0034 0.0161 0.0704
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0023 0.0191
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0125
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.1103 0.5408
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1984 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0099 0.0138
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Onchocerca volvulus 0.0241 0.1589 0.7839
Echinococcus multilocularis GPCR, family 2 0.0016 0.0034 0.0139
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0411 0.2765 0.3835
Onchocerca volvulus Peroxidasin homolog 0.0031 0.0136 0.0565
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0234 0.1026
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0411 0.2765 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0054
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0034 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0134 0.0651
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0099 0.048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0023 0.0191
Echinococcus granulosus GPCR family 2 0.0016 0.0034 0.0139
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0134 0.1194
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0023 0.0104
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0898 0.1217
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0134 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Onchocerca volvulus 0.0167 0.1077 0.5273
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0094 0.0089
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0134 0.0651
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.008 0.0069
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.016 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0234 0.2106
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0285
Schistosoma mansoni nuclear hormone receptor 0.003 0.0134 0.1194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0134 0.0582
Schistosoma mansoni nephrin 0.0014 0.0022 0.018
Brugia malayi hypothetical protein 0.0016 0.0035 0.0163
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0116 0.0565
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0034 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0134 0.0651
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0234 0.1149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0134 0.0582
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Brugia malayi steroid hormone receptor 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.005 0.0269 0.1323
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0035 0.0298
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0134 0.0582
Mycobacterium ulcerans polyketide synthase 0.0025 0.0094 0.0063
Brugia malayi isocitrate dehydrogenase 0.0016 0.0034 0.0157
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0023 0.0104
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1984 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0186 0.026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0134 0.0582
Schistosoma mansoni nuclear receptor 0.0014 0.0023 0.0191
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0411 0.2765 0.2743
Brugia malayi Blistered cuticle protein 3 0.0028 0.0116 0.0565
Loa Loa (eye worm) blistered cuticle protein 3 0.0028 0.0116 0.0565
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0214 0.0925
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0023 0.0104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0116 0.0565
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.1187 0.5868
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0214 0.0925
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0031 0.0043
Onchocerca volvulus Dual oxidase homolog 0.0028 0.0116 0.0465
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0057 0.0038
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.0261 0.1191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0034 0.0139
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0899 0.4438
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0035 0.0163
Brugia malayi hypothetical protein 0.0014 0.0023 0.0104
Brugia malayi ecdysteroid receptor 0.003 0.0134 0.0651
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0105 0.0147
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0094 0.0063
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0099 0.048
Onchocerca volvulus 0.0303 0.2021 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0105 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0134 0.0651
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0134 0.0651
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1458 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0035 0.0163
Onchocerca volvulus 0.0025 0.0099 0.038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0134 0.0651
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0094 0.0089
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.006 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0134 0.0651
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0134 0.1194
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0134 0.1194
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0134 0.0651
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0134 0.0582
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1458 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0134 0.1194
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0105 0.0105
Loa Loa (eye worm) animal heme peroxidase 0.0031 0.0136 0.0663
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0034 0.0287
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0023 0.0093
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.1984 1
Echinococcus multilocularis tumor protein p63 0.0338 0.2261 1
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0134 0.0553
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0234 0.1149
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0023 0.0093
Brugia malayi tailless protein 0.0014 0.0023 0.0104
Toxoplasma gondii hypothetical protein 0.0048 0.0257 0.0866
Echinococcus granulosus twitchin 0.0014 0.0022 0.0088
Schistosoma mansoni coup transcription factor 0.003 0.0134 0.1194
Onchocerca volvulus Peroxidase homolog 0.0028 0.0116 0.0465
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1047 0.716 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0094 0.0454
Schistosoma mansoni peroxidasin 0.0028 0.0116 0.1035
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0034 0.016 0.0783
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0046 0.0097
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0023 0.0191
Echinococcus granulosus roundabout 2 0.0018 0.0047 0.02
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0023 0.0093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0023 0.0093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0163
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0899 0.4438
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0035 0.0298
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0134 0.1194
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.014
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0134 0.0582
Schistosoma mansoni thyroid hormone receptor 0.003 0.0134 0.1194
Brugia malayi Pax transcription factor protein 2 0.0241 0.1589 0.7862
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0035 0.0163
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0023 0.0093
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0105 0.0315
Schistosoma mansoni cell adhesion molecule 0.0015 0.0027 0.023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0134 0.1194
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0023 0.0191
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0134 0.1194
Onchocerca volvulus 0.0047 0.0249 0.1133
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0035 0.0145
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0023 0.0191
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0134 0.0582
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0134 0.0582
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0134 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Mycobacterium ulcerans thioesterase 0.0023 0.008 0.005
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0094 0.0131
Brugia malayi hypothetical protein 0.0016 0.0035 0.0163
Echinococcus granulosus tumor protein p63 0.0338 0.2261 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.1984 1
Loa Loa (eye worm) acyl carrier protein 0.0012 0.001 0.0041
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0214 0.0925
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.1917 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.016 0.1435
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0134 0.0651
Onchocerca volvulus 0.0028 0.0116 0.0465
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0134 0.0651
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0116 0.0565
Echinococcus granulosus FTZ F1 alpha 0.003 0.0134 0.0582
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0214 0.0925
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0134 0.0582
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0116 0.0565
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0134 0.0553
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1009 0.141
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0269 0.1323
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0034 0.0139
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0034 0.014
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0094 0.0131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0023 0.0093
Mycobacterium ulcerans thioesterase TesA 0.0023 0.008 0.005
Schistosoma mansoni peroxidasin 0.0031 0.0141 0.1265
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0134 0.0582
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0134 0.0582
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0023 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0134 0.0651
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0898 0.087
Onchocerca volvulus Peroxidase homolog 0.0028 0.0116 0.0465
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0034 0.0139
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0094 0.0063
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0094 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0134 0.0651
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0023 0.0093
Mycobacterium ulcerans hypothetical protein 0.0157 0.1009 0.0982
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0277 0.1249
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0788
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0134 0.0582
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0651
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1917 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0267 0.2401
Brugia malayi hypothetical protein 0.0014 0.0023 0.0104
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0134 0.0553
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0105 0.0147
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0034 0.0047
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0034 0.5
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0034 0.014
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0034 0.0156
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0104
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0134 0.0582
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0186 0.0218
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1047 0.716 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0057 0.014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0134 0.0651
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0565
Schistosoma mansoni hypothetical protein 0.0171 0.1103 1
Schistosoma mansoni nuclear receptor 0.0014 0.0023 0.0191
Schistosoma mansoni thyroid hormone receptor 0.003 0.0134 0.1194
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0023 0.0104
Loa Loa (eye worm) hypothetical protein 0.0303 0.2021 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0105 0.0147
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0134 0.0582
Schistosoma mansoni hypothetical protein 0.0171 0.1103 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0134 0.0651
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0234 0.1026
Loa Loa (eye worm) DR-78 0.0014 0.0023 0.0104
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0023 0.0093
Brugia malayi nuclear hormone receptor 0.003 0.0134 0.0651
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0269 0.1323
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0034 0.0156
Brugia malayi hypothetical protein 0.0028 0.0116 0.0565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0234 0.2106
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0105 0.0075

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7 nM Inhibitory activity towards vascular endothelial growth factor receptor 2 ChEMBL. 15125964
IC50 (binding) = 7 nM Inhibitory activity towards vascular endothelial growth factor receptor 2 ChEMBL. 15125964
Selectivity (binding) = 51 Selectivity for Fibroblast growth factor receptor 2 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 164 Selectivity for Fibroblast growth factor receptor 1 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 280 Selectivity for Src protein tryrosine kinase over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 0.3 Selectivity for PDGFRbeta over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 2 Selectivity for Vascular endothelial growth factor receptor 3 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 3 Selectivity for Vascular endothelial growth factor receptor 1 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 51 Selectivity for Fibroblast growth factor receptor 2 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 164 Selectivity for Fibroblast growth factor receptor 1 over (KDR) kinase insert domain receptor ChEMBL. 15125964
Selectivity (binding) = 280 Selectivity for Src protein tryrosine kinase over (KDR) kinase insert domain receptor ChEMBL. 15125964

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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