Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0153 | 0.0336 | 0.0329 |
Onchocerca volvulus | 0.0113 | 0.0209 | 0.0979 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0153 | 0.0336 | 0.0329 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0153 | 0.0336 | 0.0329 |
Brugia malayi | beta-lactamase family protein | 0.0113 | 0.0209 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0209 | 0.0209 |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.002 | 0.0013 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.0334 | 0.0327 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0153 | 0.0336 | 0.0329 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0153 | 0.0336 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0336 | 0.0336 |
Onchocerca volvulus | 0.0667 | 0.195 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 0.0209 | 0.0359 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 0.0209 | 0.0359 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0667 | 0.195 | 0.1945 |
Brugia malayi | hypothetical protein | 0.0153 | 0.0336 | 0.0336 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0153 | 0.0336 | 0.0329 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0153 | 0.0336 | 0.0336 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0182 | 0.0176 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0177 | 0.0411 | 0.0404 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0216 | 0.0533 | 0.0527 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0317 | 0.0852 | 0.1462 |
Onchocerca volvulus | 0.0153 | 0.0336 | 0.1637 | |
Loa Loa (eye worm) | norepinephrine transporter | 0.0153 | 0.0336 | 0.0336 |
Onchocerca volvulus | 0.0153 | 0.0336 | 0.1637 | |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0153 | 0.0336 | 0.0396 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0153 | 0.0336 | 0.0329 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0317 | 0.0852 | 0.0657 |
Toxoplasma gondii | hypothetical protein | 0.0153 | 0.0336 | 0.0396 |
Plasmodium vivax | amine transporter, putative | 0.0153 | 0.0336 | 0.0396 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0317 | 0.0852 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.3231 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1903 | 0.5829 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0786 | 0.2324 | 0.2318 |
Leishmania major | hypothetical protein, conserved | 0.0081 | 0.0109 | 0.0188 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0113 | 0.0209 | 0.0359 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0182 | 0.0182 |
Brugia malayi | Dihydrofolate reductase | 0.3231 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0153 | 0.0336 | 0.0336 |
Brugia malayi | MH2 domain containing protein | 0.0254 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0209 | 0.0209 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.0007 | 0.0007 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0786 | 0.2324 | 0.2318 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0786 | 0.2324 | 0.2324 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0254 | 0.0653 | 0.0653 |
Onchocerca volvulus | 0.0102 | 0.0177 | 0.0812 | |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.0661 | 0.0661 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0152 | 0.0333 | 0.0333 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0153 | 0.0336 | 0.0329 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0336 | 0.0336 |
Mycobacterium ulcerans | beta-lactamase | 0.0113 | 0.0209 | 0.0209 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0786 | 0.2324 | 0.2324 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0081 | 0.0109 | 0.0188 |
Plasmodium vivax | hypothetical protein, conserved | 0.0113 | 0.0209 | 0.0174 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1903 | 0.5829 | 1 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0153 | 0.0336 | 0.0329 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0177 | 0.0411 | 0.0411 |
Mycobacterium ulcerans | thymidylate synthase | 0.0667 | 0.195 | 0.195 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3231 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0336 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.0533 | 0.0533 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3231 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.088 | 0.2619 | 0.2614 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0177 | 0.0411 | 0.0404 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3231 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.002 | 0.0013 |
Brugia malayi | Cytochrome P450 family protein | 0.011 | 0.02 | 0.02 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0257 | 0.0661 | 0.0655 |
Plasmodium vivax | hypothetical protein, conserved | 0.0153 | 0.0336 | 0.0396 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0209 | 0.0209 |
Onchocerca volvulus | 0.0153 | 0.0336 | 0.1637 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0113 | 0.0209 | 0.0209 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0257 | 0.0661 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0209 | 0.0209 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0153 | 0.0336 | 0.0336 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1903 | 0.5829 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.1474 | 0.4484 | 0.448 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0336 | 0.0336 |
Plasmodium falciparum | amino acid transporter, putative | 0.0153 | 0.0336 | 0.0396 |
Echinococcus multilocularis | thymidylate synthase | 0.0667 | 0.195 | 0.1945 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0786 | 0.2324 | 0.2318 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0081 | 0.0109 | 0.0188 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0113 | 0.0209 | 0.0209 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0153 | 0.0336 | 0.0329 |
Mycobacterium ulcerans | hypothetical protein | 0.0113 | 0.0209 | 0.0209 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1387 | 0.4209 | 0.4205 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0113 | 0.0209 | 0.0202 |
Mycobacterium ulcerans | lipase LipD | 0.0113 | 0.0209 | 0.0209 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0153 | 0.0336 | 0.0329 |
Brugia malayi | hypothetical protein | 0.0257 | 0.0661 | 0.0661 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0152 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0209 | 0.0209 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0152 | 0.0333 | 0.0333 |
Brugia malayi | beta-lactamase family protein | 0.0113 | 0.0209 | 0.0209 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3231 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0667 | 0.195 | 0.195 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1387 | 0.4209 | 0.4205 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0153 | 0.0336 | 0.0329 |
Loa Loa (eye worm) | serotonin transporter b | 0.0153 | 0.0336 | 0.0336 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0786 | 0.2324 | 0.2318 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0153 | 0.0336 | 0.0329 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0333 | 0.0333 |
Echinococcus granulosus | thymidylate synthase | 0.0667 | 0.195 | 0.1945 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0153 | 0.0336 | 0.0336 |
Toxoplasma gondii | ABC1 family protein | 0.0113 | 0.0209 | 0.0174 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.0334 | 0.0327 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0113 | 0.0209 | 0.0202 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0113 | 0.0209 | 0.0209 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0113 | 0.0209 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0336 | 0.0336 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0153 | 0.0336 | 0.0336 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0153 | 0.0336 | 0.0329 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0153 | 0.0336 | 0.0329 |
Brugia malayi | hypothetical protein | 0.0317 | 0.0852 | 0.0852 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1903 | 0.5829 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0667 | 0.195 | 0.1779 |
Brugia malayi | beta-lactamase | 0.0113 | 0.0209 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0109 | 0.0109 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1387 | 0.4209 | 0.4205 |
Loa Loa (eye worm) | thymidylate synthase | 0.0667 | 0.195 | 0.195 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3231 | 1 | 1 |
Onchocerca volvulus | 0.0153 | 0.0336 | 0.1637 | |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0336 | 0.0336 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0153 | 0.0336 | 0.5 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0153 | 0.0336 | 0.0329 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0113 | 0.0209 | 0.0202 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0177 | 0.0411 | 0.0404 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0113 | 0.0209 | 0.0209 |
Onchocerca volvulus | 0.0113 | 0.0209 | 0.0979 | |
Loa Loa (eye worm) | beta-lactamase | 0.0113 | 0.0209 | 0.0209 |
Onchocerca volvulus | 0.0113 | 0.0209 | 0.0979 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0786 | 0.2324 | 0.2318 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0667 | 0.195 | 0.1779 |
Echinococcus multilocularis | tumor protein p63 | 0.1474 | 0.4484 | 0.448 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0177 | 0.0411 | 0.0411 |
Plasmodium falciparum | transporter, putative | 0.0153 | 0.0336 | 0.0396 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0153 | 0.0336 | 0.0396 |
Echinococcus granulosus | dihydrofolate reductase | 0.3231 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0113 | 0.0209 | 0.0359 |
Echinococcus granulosus | serotonin transporter | 0.0153 | 0.0336 | 0.0329 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0081 | 0.0109 | 0.0188 |
Echinococcus multilocularis | serotonin transporter | 0.0153 | 0.0336 | 0.0329 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0786 | 0.2324 | 0.2318 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0786 | 0.2324 | 0.2324 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1903 | 0.5829 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0786 | 0.2324 | 0.2324 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0336 | 0.0336 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0153 | 0.0336 | 0.0329 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.002 | 0.002 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0104 | 0.0182 | 0.0182 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1903 | 0.5829 | 1 |
Onchocerca volvulus | 0.0216 | 0.0533 | 0.2658 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0254 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0209 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0336 | 0.0336 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3231 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0153 | 0.0336 | 0.0329 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0153 | 0.0336 | 0.0396 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0153 | 0.0336 | 0.0329 |
Toxoplasma gondii | hypothetical protein | 0.0153 | 0.0336 | 0.0396 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0007 | 0.0007 |
Brugia malayi | hypothetical protein | 0.0052 | 0.002 | 0.002 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.011 | 0.02 | 0.02 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0719 | 0.2113 | 0.1945 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.