Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.5984 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.5984 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.5984 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.5984 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.5984 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.5984 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.5984 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.5984 | 1 | 0.5 |
Toxoplasma gondii | MAPEG family protein | 0.4936 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.5984 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 4 ug ml-1 | Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis isolate 44 from Chinese tuberculosis patient measured 24 hrs post dose by microplate alamar blue assay | ChEMBL. | 22503208 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.