Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0101 | 0.0152 | 0.0152 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.4205 | 1 | 1 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0039 | 0.0002 | 1 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0039 | 0.0002 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 0.0085 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4205 | 1 | 1 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0039 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0085 | 0.0085 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0048 | 0.0024 | 0.0646 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4205 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0074 | 0.0085 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0039 | 0.0002 | 0.0002 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0272 | 0.056 | 0.056 |
Brugia malayi | Probable ClpP-like protease | 0.0074 | 0.0085 | 0.0085 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 0.0085 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0074 | 0.0085 | 0.0085 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4205 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4205 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0101 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.4205 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0048 | 0.0024 | 0.2864 |
Schistosoma mansoni | na/ca exchanger | 0.0039 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0039 | 0.0002 | 0.0051 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0039 | 0.0002 | 0.0002 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.4205 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0074 | 0.0085 | 0.0085 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.4205 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.4205 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 8 | 0.1539 | 0.3603 | 0.3603 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0616 | 0.1386 | 0.1386 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0039 | 0.0002 | 0.0002 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0039 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0048 | 0.0024 | 0.0646 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0195 | 0.0378 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0074 | 0.0085 | 0.0085 |
Echinococcus multilocularis | sodium calcium exchanger | 0.1539 | 0.3603 | 0.3603 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.4205 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.4205 | 1 | 1 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0039 | 0.0002 | 0.0228 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0039 | 0.0002 | 0.0002 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0074 | 0.0085 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4205 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.4205 | 1 | 1 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0039 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0039 | 0.0002 | 0.0002 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0039 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.1386 | 0.1386 |
Echinococcus granulosus | sodium calcium exchanger | 0.1539 | 0.3603 | 0.3603 |
Giardia lamblia | Kinase, CMGC MAPK | 0.4205 | 1 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0272 | 0.056 | 0.056 |
Trichomonas vaginalis | CMGC family protein kinase | 0.4205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Schistosoma mansoni | sodium/calcium exchanger | 0.1539 | 0.3603 | 0.3603 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0039 | 0.0002 | 0.0002 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.4205 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.4205 | 1 | 1 |
Plasmodium falciparum | cation/H+ antiporter | 0.0039 | 0.0002 | 0.0228 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0048 | 0.0024 | 0.0024 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.4205 | 1 | 1 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0039 | 0.0002 | 0.0228 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0048 | 0.0024 | 0.0024 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0002 | 0.0002 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0074 | 0.0085 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.4205 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.4205 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0101 | 0.0152 | 0.0152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.