Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0141 | 0.0113 | 0.0089 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0153 | 0.0131 | 0.0104 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0179 | 0.0175 | 0.0175 |
Brugia malayi | isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0104 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.6232 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.047 | 0.0647 | 0.0647 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0153 | 0.0131 | 0.2145 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0175 | 0.0168 | 0.0141 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0087 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.6232 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.0643 | 0.062 |
Brugia malayi | TAR-binding protein | 0.0141 | 0.0113 | 0.0085 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0104 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.6232 | 1 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0175 | 0.0168 | 0.0141 |
Trichomonas vaginalis | CMGC family protein kinase | 0.6232 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.6232 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0256 | 0.0299 | 0.0271 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0885 | 0.132 | 0.1296 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0386 | 0.051 | 0.0483 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.013 | 0.0094 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.032 | 0.0296 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0168 | 0.0144 |
Trichomonas vaginalis | CMGC family protein kinase | 0.6232 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0863 | 0.1285 | 0.1261 |
Schistosoma mansoni | serine/threonine protein kinase | 0.013 | 0.0094 | 0.0094 |
Entamoeba histolytica | hypothetical protein, conserved | 0.4366 | 0.697 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.4366 | 0.697 | 0.6962 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0034 | 0.0006 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.047 | 0.0647 | 0.0621 |
Giardia lamblia | Kinase, PLK | 0.013 | 0.0094 | 0.0066 |
Brugia malayi | RNA binding protein | 0.0141 | 0.0113 | 0.0085 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0175 | 0.0168 | 0.0141 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0141 | 0.0113 | 0.0085 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.4366 | 0.697 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.013 | 0.0094 | 0.0066 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0175 | 0.0168 | 0.2908 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.6232 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0386 | 0.051 | 0.0483 |
Brugia malayi | hypothetical protein | 0.0249 | 0.0288 | 0.0261 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0175 | 0.0168 | 0.2908 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.4366 | 0.697 | 0.6962 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.0113 | 0.0113 |
Brugia malayi | sulfakinin receptor protein | 0.0269 | 0.032 | 0.0293 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.028 | 0.0338 | 0.0311 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.0165 | 0.0165 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.0338 | 0.0338 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0153 | 0.0131 | 0.0104 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.0338 | 0.0338 |
Brugia malayi | hypothetical protein | 0.0468 | 0.0643 | 0.0617 |
Trichomonas vaginalis | CAMK family protein kinase | 0.013 | 0.0094 | 0.0066 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.6232 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.013 | 0.0094 | 0.0066 |
Loa Loa (eye worm) | RNA binding protein | 0.0141 | 0.0113 | 0.0089 |
Trichomonas vaginalis | CMGC family protein kinase | 0.6232 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.028 | 0.0338 | 0.0311 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.6232 | 1 | 1 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.4366 | 0.697 | 0.6962 |
Treponema pallidum | DNA topoisomerase I (topA) | 0.0179 | 0.0175 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0386 | 0.051 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0153 | 0.0131 | 0.0104 |
Brugia malayi | hypothetical protein | 0.0386 | 0.051 | 0.0483 |
Echinococcus granulosus | tumor protein p63 | 0.0594 | 0.0848 | 0.0822 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0104 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.013 | 0.0094 | 0.007 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.6232 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.047 | 0.0647 | 0.0624 |
Brugia malayi | hypothetical protein | 0.0269 | 0.032 | 0.0293 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0153 | 0.0131 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0594 | 0.0848 | 0.0822 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0107 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.6232 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0104 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0034 | 0.0006 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.4366 | 0.697 | 0.6962 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0179 | 0.0175 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.013 | 0.0094 | 0.0066 |
Trichomonas vaginalis | CAMK family protein kinase | 0.013 | 0.0094 | 0.0066 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.3456 | 0.5494 | 0.5481 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0386 | 0.051 | 0.0483 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.0113 | 0.0113 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0115 | 0.007 | 0.0042 |
Echinococcus granulosus | GPCR family 2 | 0.028 | 0.0338 | 0.0311 |
Trichomonas vaginalis | CAMK family protein kinase | 0.013 | 0.0094 | 0.0066 |
Echinococcus multilocularis | geminin | 0.0256 | 0.0299 | 0.0271 |
Schistosoma mansoni | serine/threonine protein kinase | 0.6232 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0141 | 0.0113 | 0.0085 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0104 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0115 | 0.007 | 0.3007 |
Loa Loa (eye worm) | hypothetical protein | 0.0885 | 0.132 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0605 | 0.0866 | 0.0843 |
Wolbachia endosymbiont of Brugia malayi | topoisomerase IA, TopA | 0.0179 | 0.0175 | 1 |
Leishmania major | DNA topoisomerase III, putative | 0.0179 | 0.0175 | 0.0147 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.0113 | 0.0113 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0173 | 0.0165 | 0.0137 |
Schistosoma mansoni | hypothetical protein | 0.0605 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | TAR-binding protein | 0.0141 | 0.0113 | 0.0089 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0173 | 0.0165 | 0.0137 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0104 |
Echinococcus granulosus | mitogen activated protein kinase | 0.6232 | 1 | 1 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.4366 | 0.697 | 0.6962 |
Trichomonas vaginalis | CAMK family protein kinase | 0.013 | 0.0094 | 0.0066 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0137 | 0.0106 | 0.0078 |
Trypanosoma brucei | protein kinase, putative | 0.6232 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0175 | 0.0168 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.028 | 0.0338 | 0.0311 |
Toxoplasma gondii | SWI2/SNF2-containing protein | 0.009 | 0.0031 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.0113 | 0.0113 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.047 | 0.0647 | 0.0621 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.0338 | 0.0314 |
Giardia lamblia | Rrm3p helicase | 0.4366 | 0.697 | 0.6962 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0386 | 0.051 | 0.0483 |
Brugia malayi | Probable ClpP-like protease | 0.0175 | 0.0168 | 0.0141 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.4366 | 0.697 | 0.6962 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0153 | 0.0131 | 0.0104 |
Schistosoma mansoni | kinase | 0.0094 | 0.0036 | 0.0036 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.028 | 0.0338 | 0.0311 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4366 | 0.697 | 0.6962 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.047 | 0.0647 | 0.0647 |
Schistosoma mansoni | hypothetical protein | 0.0256 | 0.0299 | 0.0299 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0104 |
Giardia lamblia | Kinase, CMGC MAPK | 0.6232 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0863 | 0.1285 | 0.1264 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0885 | 0.132 | 0.1296 |
Echinococcus multilocularis | GPCR, family 2 | 0.028 | 0.0338 | 0.0311 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.0338 | 0.0338 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.4366 | 0.697 | 0.6962 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0089 | 0.0028 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.4366 | 0.697 | 0.697 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0153 | 0.0131 | 0.0104 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.6232 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.028 | 0.0338 | 0.0314 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.028 | 0.0338 | 0.0311 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.013 | 0.0094 | 0.0066 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.6232 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.013 | 0.0094 | 0.0066 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.013 | 0.0094 | 0.1122 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.047 | 0.0647 | 0.0621 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.051 | 0.0486 |
Trichomonas vaginalis | CAMK family protein kinase | 0.013 | 0.0094 | 0.0066 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0605 | 0.0866 | 0.084 |
Brugia malayi | Isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0104 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0175 | 0.0168 | 0.0141 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0115 | 0.007 | 0.0042 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0885 | 0.132 | 0.1298 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.013 | 0.0094 | 0.0095 |
Trichomonas vaginalis | CMGC family protein kinase | 0.6232 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.013 | 0.0094 | 0.0066 |
Onchocerca volvulus | 0.0468 | 0.0643 | 1 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0386 | 0.051 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0175 | 0.0168 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.4366 | 0.697 | 0.6962 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.047 | 0.0647 | 0.0621 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0175 | 0.0168 | 0.0168 |
Leishmania major | hypothetical protein, conserved | 0.0386 | 0.051 | 0.0483 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.047 | 0.0647 | 0.0621 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0863 | 0.1285 | 0.1264 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.0338 | 0.0338 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0153 | 0.0131 | 0.0131 |
Echinococcus multilocularis | tar DNA binding protein | 0.0141 | 0.0113 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0256 | 0.0299 | 0.0299 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.4366 | 0.697 | 0.6962 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0175 | 0.0168 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0153 | 0.0131 | 0.2145 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.013 | 0.0094 | 0.0066 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.028 | 0.0338 | 0.0311 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0386 | 0.051 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.6232 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0153 | 0.0131 | 0.0104 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.047 | 0.0647 | 0.0647 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.013 | 0.0094 | 0.0066 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.0113 | 0.0113 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.