Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.0452 | 0.1039 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0579 | 0.1392 | 0.1316 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0124 | 0.0127 | 0.0039 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0109 | 0.0088 | 0.0088 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0579 | 0.1392 | 0.1389 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0124 | 0.0127 | 0.0127 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0109 | 0.0088 | 0.0088 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.1089 | 0.281 | 0.2746 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0345 | 0.0741 | 0.0659 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0579 | 0.1392 | 0.1316 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0452 | 0.1039 | 0.096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0174 | 0.0267 | 0.0264 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1063 | 0.2737 | 0.2673 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3677 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0188 | 0.0305 | 0.2289 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0124 | 0.0127 | 0.0123 |
Brugia malayi | TAR-binding protein | 0.0174 | 0.0267 | 0.0181 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0124 | 0.0127 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0124 | 0.0127 | 0.0039 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0345 | 0.0741 | 0.0659 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0216 | 0.0383 | 0.0298 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0124 | 0.0127 | 0.0127 |
Brugia malayi | Probable ClpP-like protease | 0.0216 | 0.0383 | 0.0298 |
Brugia malayi | MH2 domain containing protein | 0.1063 | 0.2737 | 0.2673 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0452 | 0.1039 | 0.096 |
Leishmania major | hypothetical protein, conserved | 0.0452 | 0.1039 | 0.096 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.0741 | 0.0738 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0216 | 0.0383 | 0.3103 |
Brugia malayi | Isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.3677 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.0302 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0188 | 0.0305 | 0.2289 |
Trypanosoma brucei | polo-like protein kinase | 0.0124 | 0.0127 | 0.0039 |
Echinococcus multilocularis | GPCR, family 2 | 0.0345 | 0.0741 | 0.0659 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0452 | 0.1039 | 0.096 |
Toxoplasma gondii | SWI2/SNF2-containing protein | 0.0111 | 0.0093 | 0.0005 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Schistosoma mansoni | tar DNA-binding protein | 0.0174 | 0.0267 | 0.0264 |
Brugia malayi | RNA binding protein | 0.0174 | 0.0267 | 0.0181 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0188 | 0.0305 | 0.022 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0188 | 0.0305 | 0.022 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0188 | 0.0305 | 0.022 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0345 | 0.0741 | 0.0659 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.3677 | 1 | 1 |
Treponema pallidum | DNA topoisomerase I (topA) | 0.0221 | 0.0397 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.3677 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0124 | 0.0127 | 0.0039 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0216 | 0.0383 | 0.0298 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0216 | 0.0383 | 0.3103 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.3677 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0452 | 0.1039 | 1 |
Giardia lamblia | Kinase, PLK | 0.0124 | 0.0127 | 0.0039 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0579 | 0.1392 | 0.1389 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0124 | 0.0127 | 0.0127 |
Brugia malayi | isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0124 | 0.0127 | 0.0127 |
Schistosoma mansoni | tar DNA-binding protein | 0.0174 | 0.0267 | 0.0264 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0579 | 0.1392 | 0.1389 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0203 | 0.0347 | 0.0261 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0188 | 0.0305 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 0.1039 | 0.096 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0124 | 0.0127 | 0.0039 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0345 | 0.0741 | 0.0659 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0579 | 0.1392 | 0.1316 |
Echinococcus granulosus | tar DNA binding protein | 0.0174 | 0.0267 | 0.0181 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3677 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0124 | 0.0127 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.0741 | 0.0738 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0124 | 0.0127 | 0.0127 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0216 | 0.0383 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0188 | 0.0305 | 0.022 |
Brugia malayi | hypothetical protein | 0.0576 | 0.1383 | 0.1307 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.3677 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0452 | 0.1039 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0745 | 0.1852 | 0.178 |
Trypanosoma brucei | protein kinase, putative | 0.3677 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0345 | 0.0741 | 0.0659 |
Schistosoma mansoni | tar DNA-binding protein | 0.0174 | 0.0267 | 0.0264 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0216 | 0.0383 | 1 |
Brugia malayi | hypothetical protein | 0.0452 | 0.1039 | 0.096 |
Wolbachia endosymbiont of Brugia malayi | topoisomerase IA, TopA | 0.0221 | 0.0397 | 1 |
Leishmania major | DNA topoisomerase III, putative | 0.0221 | 0.0397 | 0.0312 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0216 | 0.0383 | 0.0298 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0345 | 0.0741 | 0.0659 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1063 | 0.2737 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0576 | 0.1383 | 0.1307 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0141 | 0.0176 | 0.009 |
Brugia malayi | hypothetical protein | 0.0292 | 0.0594 | 0.0511 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.3677 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3677 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0174 | 0.0267 | 0.0264 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0141 | 0.0176 | 0.3007 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.3677 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3677 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.0347 | 0.0344 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0745 | 0.1852 | 0.178 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.3677 | 1 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0203 | 0.0347 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.0741 | 0.0659 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0579 | 0.1392 | 0.1316 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3677 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0452 | 0.1039 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0174 | 0.0267 | 0.0181 |
Onchocerca volvulus | 0.0576 | 0.1383 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0579 | 0.1392 | 0.1316 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.0741 | 0.0738 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.0741 | 0.0738 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0221 | 0.0397 | 0.0394 |
Schistosoma mansoni | hypothetical protein | 0.0745 | 0.1852 | 0.185 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1089 | 0.281 | 0.2746 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0124 | 0.0127 | 0.0127 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0216 | 0.0383 | 0.0298 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0174 | 0.0267 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.1089 | 0.281 | 0.2746 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0124 | 0.0127 | 0.0039 |
Loa Loa (eye worm) | TAR-binding protein | 0.0174 | 0.0267 | 0.0181 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0345 | 0.0741 | 0.0659 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1089 | 0.281 | 0.2746 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0579 | 0.1392 | 0.1316 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0141 | 0.0176 | 0.009 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0168 | 0.0251 | 0.0165 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0188 | 0.0305 | 0.022 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0216 | 0.0383 | 0.038 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0188 | 0.0305 | 0.022 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0221 | 0.0397 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0216 | 0.0383 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.3677 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0345 | 0.0741 | 0.0659 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0188 | 0.0305 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.0383 | 0.0298 |
Loa Loa (eye worm) | RNA binding protein | 0.0174 | 0.0267 | 0.0181 |
Echinococcus multilocularis | tar DNA binding protein | 0.0174 | 0.0267 | 0.0181 |
Echinococcus granulosus | mitogen activated protein kinase | 0.3677 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0124 | 0.0127 | 0.0039 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0124 | 0.0127 | 0.0127 |
Giardia lamblia | Kinase, CMGC MAPK | 0.3677 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3677 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.3677 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.3677 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.