TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 443.827 | Formula: C18H13ClF3N3O3S
H donors: 3 H acceptors: 3 LogP: 3.81 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc2c1cc(cc2)S(=O)(=O)N)Nc1ccc(c(c1)C(F)(F)F)Cl
InChi: 1S/C18H13ClF3N3O3S/c19-15-7-5-11(8-14(15)18(20,21)22)24-17(26)25-16-3-1-2-10-4-6-12(9-13(10)16)29(23,27)28/h1-9H,(H2,23,27,28)(H2,24,25,26)
InChiKey: ZCGDVVBZZYKINE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	cell division protein kinase 2, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Chlamydia trachomatis	serine/threonine-protein kinase	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0026	0	0.5
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.2872	1	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0026	0	0.5
Plasmodium falciparum	mitogen-activated protein kinase 1	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	tyrosine kinase-like protein, putative	0.0026	0	0.5
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.2872	1	1
Entamoeba histolytica	casein kinase 1, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2872	1	1
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Mycobacterium ulcerans	membrane-anchored serine/threonine-protein kinase	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Echinococcus granulosus	mitogen activated protein kinase	0.2872	1	1
Mycobacterium ulcerans	serine/threonine-protein kinase PknG	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Mycobacterium ulcerans	transmembrane serine/threonine-protein kinase PknQ	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Chlamydia trachomatis	serine/threonine protein kinase	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	NIMA-related protein kinase (Pfnek-1), putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine- protein kinase DCAMKL3, putative	0.0026	0	0.5
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0026	0	0.5
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Giardia lamblia	Kinase, CMGC MAPK	0.2872	1	1
Plasmodium falciparum	protein serine/threonine kinase-1	0.0026	0	0.5
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	casein kinase 1	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	EKC/KEOPS complex subunit BUD32, putative	0.0026	0	0.5
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Mycobacterium leprae	PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H)	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium vivax	unspecified product	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	mitogen-activated protein kinase 1, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.2872	1	1
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.2872	1	1
Plasmodium falciparum	cdc2-related protein kinase 1	0.0026	0	0.5
Entamoeba histolytica	serine/threonine- protein kinase C823.03, putative	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	serine/threonine protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	calcium-dependent protein kinase 6	0.0026	0	0.5
Entamoeba histolytica	cell division protein kinase 2, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	NIMA related kinase 1	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	cyclin g-associated kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	hypothetical protein, conserved	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Plasmodium vivax	eukaryotic translation initiation factor 2-alpha kinase, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0026	0	0.5
Plasmodium falciparum	protein kinase 1	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	casein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-like	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Plasmodium vivax	serine/threonine-specific protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Plasmodium falciparum	protein kinase 5	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0026	0	0.5
Plasmodium vivax	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	serine/threonine-protein kinase PRP4K, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Giardia lamblia	Kinase, STE STE20	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0026	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.2872	1	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.2872	1	1
Onchocerca volvulus		0.0026	0	0.5
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2872	1	1
Mycobacterium ulcerans	serine/threonine-protein kinase a PknA	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK-like	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	cyclin-dependent kinase protein, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	HEAT repeat domain containing protein	0.0026	0	0.5
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0026	0	0.5
Plasmodium falciparum	eukaryotic initiation factor 2alpha kinase 1	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	serine/threonine protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0026	0	0.5
Plasmodium vivax	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Plasmodium vivax	serine/threonine-protein kinase Nek1, putative	0.0026	0	0.5
Plasmodium vivax	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Mycobacterium tuberculosis	Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K)	0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	cdc2-related protein kinase 5	0.0026	0	0.5
Plasmodium vivax	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	cell division protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	cdc2-related protein kinase 3	0.0026	0	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	calcium/calmodulin-dependent protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase KIN	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Echinococcus multilocularis	calcium activated potassium channel	0.003	0.0014	0.0014
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	cdc2-related protein kinase 4	0.0026	0	0.5
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Plasmodium falciparum	calcium-dependent protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus	Asator homolog	0.0026	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0026	0	0.5
Trypanosoma brucei	protein kinase, putative	0.2872	1	1
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	3-phosphoinositide dependent protein kinase-1, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	serine/threonine protein kinase VPS15, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Schistosoma mansoni	serine/threonine protein kinase	0.2872	1	1
Plasmodium vivax	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase , putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Chlamydia trachomatis	serine/threonine protein kinase	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	NIMA related kinase 3	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Echinococcus multilocularis	mitogen activated protein kinase 3	0.2872	1	1
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Trichomonas vaginalis	harmonin-interacting ankyrin-repeat containing protein (harp), sans, putative	0.0026	0.0000000070751	0.0000000070751
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_3	0.0026	0	0.5
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0026	0	0.5
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	serine/threonine protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-like	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Onchocerca volvulus	Kinase homolog	0.0026	0	0.5
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	serine/threonine-protein kinase 2, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	protein kinase 2	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	casein kinase II alpha subunit, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium falciparum	MO15-related protein kinase	0.0026	0	0.5
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0026	0	0.5
Mycobacterium tuberculosis	Serine/threonine-protein kinase PknG (protein kinase G) (STPK G)	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0026	0	0.5
Plasmodium vivax	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	eukaryotic translation initiation factor 2-alpha kinase	0.0026	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.2872	1	1
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	glycogen synthase kinase 3	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.2872	1	1
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	serine/threonine protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	casein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-like	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_2	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	cGMP-dependent protein kinase	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Trichomonas vaginalis	CMGC family protein kinase	0.2872	1	1
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Echinococcus granulosus	calcium activated potassium channel	0.003	0.0014	0.0014
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	protein kinase Crk2	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Plasmodium vivax	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase with WD repeats	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	cell division protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Plasmodium falciparum	protein kinase 6	0.0026	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase 2, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Entamoeba histolytica	predicted protein	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	cdc2-like protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Plasmodium falciparum	NIMA related kinase 4	0.0026	0	0.5
Plasmodium vivax	calcium-dependent protein kinase 6, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase STE20, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.2872	1	1
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Mycobacterium tuberculosis	Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F)	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	casein kinase I isoform delta, putative	0.0026	0	0.5
Plasmodium vivax	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.2872	1	1
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	casein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Entamoeba histolytica	mitogen-activated protein kinase	0.0026	0	0.5
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	cdc2-related protein kinase 1, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	p21-activated kinase	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium falciparum	NIMA related kinase 2	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0026	0	0.5
Mycobacterium ulcerans	serine/threonine-protein kinase PknF_2	0.0026	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase 3, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	casein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	protein kinase, putative	0.0026	0	0.5
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	casein kinase 1, putative	0.0026	0	0.5
Plasmodium vivax	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0026	0	0.5
Onchocerca volvulus	Protein kinase homolog	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	serine/threonine-protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	serine/threonine kinase-1, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-GL-like	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0026	0	0.5
Echinococcus granulosus	mitogen activated protein kinase 3	0.2872	1	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Plasmodium falciparum	protein kinase 7	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	serine/threonine protein kinase	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0026	0	0.5
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E)	0.0026	0	0.5
Plasmodium vivax	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Plasmodium vivax	protein kinase domain containing protein	0.0026	0	0.5
Entamoeba histolytica	casein kinase, putative	0.0026	0	0.5
Plasmodium vivax	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-like	0.0026	0.0000000070751	0.0000000070751
Plasmodium falciparum	calcium/calmodulin-dependent protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Onchocerca volvulus		0.0026	0	0.5
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0026	0	0.5
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Giardia lamblia	Kinase, NEK	0.0026	0.0000000070751	0.0000000070751
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Mycobacterium ulcerans	anchored-membrane serine/threonine-protein kinase PknF	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Echinococcus multilocularis	mitogen activated protein kinase	0.2872	1	1
Plasmodium vivax	serine/threonine-protein kinase NEK4, putative	0.0026	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0	0.5
Entamoeba histolytica	Rab GTPase activating protein, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0026	0	0.5
Plasmodium vivax	serine/threonine-protein kinase Nek1, putative	0.0026	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0	0.5
Onchocerca volvulus		0.0026	0	0.5
Plasmodium falciparum	serine/threonine protein kinase, FIKK family	0.0026	0	0.5
Plasmodium falciparum	EKC/KEOPS complex subunit BUD32	0.0026	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 710 nM	Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifearase reporter gene assay	ChEMBL.	22525313

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2024503

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1640786