Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0241 | 0.1478 | 0.1758 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0145 | 0.5 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0176 | 0.0969 | 1 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks4 | 0.0108 | 0.0433 | 0.0394 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0176 | 0.0969 | 0.2104 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.08 | 0.1739 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0571 | 0.406 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0143 | 0.071 | 0.1511 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0745 | 0.5423 | 0.6903 |
Loa Loa (eye worm) | acyl carrier protein | 0.0071 | 0.0145 | 0.009 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0071 | 0.0145 | 0.0186 |
Schistosoma mansoni | acyl carrier protein | 0.0071 | 0.0145 | 0.008 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0176 | 0.0969 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0211 | 0.1245 | 0.2836 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0571 | 0.406 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0655 | 0.4721 | 0.5987 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0701 | 0.5082 | 0.6517 |
Leishmania major | beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative | 0.0176 | 0.0969 | 0.2133 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.007 | 0.0135 | 0.0173 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.068 | 0.4914 | 0.6238 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.013 | 0.0043 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0071 | 0.0145 | 0.0032 |
Onchocerca volvulus | 0.0655 | 0.4721 | 0.4897 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0082 | 0.0232 | 0.019 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Meromycolate extension acyl carrier protein AcpM | 0.0071 | 0.0145 | 0.0019 |
Onchocerca volvulus | 0.1221 | 0.9149 | 0.9635 | |
Brugia malayi | Methyltransferase-like protein 4 | 0.0211 | 0.1245 | 0.1144 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0176 | 0.0969 | 0.2104 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium ulcerans | acyl carrier protein | 0.0071 | 0.0145 | 0.0186 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0571 | 0.406 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0078 | 0.0198 | 0.0214 |
Echinococcus multilocularis | Acyl carrier protein, mitochondrial | 0.0071 | 0.0145 | 0.008 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0071 | 0.0145 | 0.0019 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0071 | 0.0145 | 0.0186 |
Echinococcus multilocularis | NADH dehydrogenase | 0.0071 | 0.0145 | 0.008 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0499 | 0.35 | 0.6366 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0571 | 0.406 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0571 | 0.406 | 0.4565 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.1178 | 0.2539 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0211 | 0.1245 | 0.2711 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.08 | 0.1739 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0701 | 0.5082 | 0.6458 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.007 | 0.0135 | 0.0012 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0078 | 0.0198 | 0.0214 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks17 | 0.0171 | 0.0932 | 0.1046 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0584 | 0.4167 | 0.5255 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0176 | 0.0969 | 0.1584 |
Mycobacterium ulcerans | acyl carrier protein | 0.0071 | 0.0145 | 0.0186 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0354 | 0.2366 | 0.4224 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1264 | 0.949 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0082 | 0.0232 | 0.0121 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0464 | 0.3222 | 0.4132 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0745 | 0.5423 | 0.6897 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0504 | 0.3535 | 0.4441 |
Mycobacterium ulcerans | polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0978 | 0.1042 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0216 | 0.1279 | 0.164 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0259 | 0.162 | 0.1524 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0192 | 0.1097 | 0.1019 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0167 |
Brugia malayi | AMP-binding enzyme family protein | 0.0216 | 0.1279 | 0.1179 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0211 | 0.1245 | 0.1453 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.1178 | 0.2539 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.007 | 0.0135 | 0.0054 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0108 | 0.0433 | 0.0394 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.0232 | 0.0302 |
Trypanosoma brucei | protein kinase, putative | 0.0571 | 0.406 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0176 | 0.0969 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0232 | 0.019 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0745 | 0.5423 | 0.6897 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0176 | 0.0969 | 0.2104 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.007 | 0.0135 | 0.0173 |
Mycobacterium ulcerans | thioesterase | 0.0584 | 0.4167 | 0.5343 |
Leishmania major | acyl carrier protein, putative | 0.0071 | 0.0145 | 0.0037 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0071 | 0.0145 | 0.0019 |
Echinococcus granulosus | acyl carrier protein mitochondrial | 0.0071 | 0.0145 | 0.008 |
Mycobacterium leprae | PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 | 0.0108 | 0.0433 | 0.0376 |
Onchocerca volvulus | 0.008 | 0.0214 | 0.0074 | |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0071 | 0.0145 | 0.0186 |
Brugia malayi | Phosphopantetheine attachment site family protein | 0.0071 | 0.0145 | 0.0032 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0043 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0116 | 0.0501 | 0.0983 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0571 | 0.406 | 1 |
Brugia malayi | acyl carrier protein, mitochondrial precursor, putative | 0.0071 | 0.0145 | 0.0032 |
Mycobacterium tuberculosis | Conserved protein | 0.0211 | 0.1245 | 0.1453 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.162 | 0.1776 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.007 | 0.0135 | 0.0006 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0143 | 0.071 | 0.1511 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0177 | 0.0978 | 0.0875 |
Mycobacterium leprae | PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) | 0.022 | 0.1315 | 0.1529 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0116 | 0.0501 | 0.0983 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0655 | 0.4721 | 0.532 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0701 | 0.5082 | 0.6458 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0574 | 0.4082 | 0.5153 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0433 | 0.0419 |
Echinococcus granulosus | AMP dependent ligase | 0.0071 | 0.0145 | 0.008 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0564 | 0.4009 | 0.5141 |
Brugia malayi | Melibiase family protein | 0.0078 | 0.0198 | 0.0085 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0399 | 0.2712 | 0.3367 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0455 | 0.3153 | 0.5711 |
Mycobacterium tuberculosis | Probable acyl carrier protein AcpA (ACP) | 0.0071 | 0.0145 | 0.0019 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0284 | 0.1811 | 0.2192 |
Loa Loa (eye worm) | fatty acid synthase | 0.0692 | 0.5009 | 0.5649 |
Loa Loa (eye worm) | beta-ketoacyl synthase domain-containing protein | 0.0176 | 0.0969 | 0.1032 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0293 | 0.1887 | 0.2081 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0571 | 0.406 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0071 | 0.0145 | 0.0019 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0701 | 0.5082 | 0.5026 |
Mycobacterium tuberculosis | Acyl carrier protein (ACP) MbtL | 0.0071 | 0.0145 | 0.0019 |
Loa Loa (eye worm) | phosphopantetheine attachment site family protein | 0.0071 | 0.0145 | 0.009 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.0232 | 0.0302 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0571 | 0.406 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.007 | 0.0135 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0071 | 0.0145 | 0.0186 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0745 | 0.5423 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0067 | 0.0113 | 0.0054 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0176 | 0.0969 | 0.1242 |
Loa Loa (eye worm) | acyl carrier protein | 0.0322 | 0.2116 | 0.2342 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.022 | 0.1315 | 0.1687 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0082 | 0.0232 | 0.0121 |
Echinococcus multilocularis | GPCR, family 2 | 0.0082 | 0.0232 | 0.0302 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0109 | 0.0446 | 0.3656 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0571 | 0.406 | 0.7425 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.0232 | 0.0302 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0571 | 0.406 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0584 | 0.4167 | 0.5343 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0167 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0571 | 0.406 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0571 | 0.406 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-(acyl carrier protein) synthase II | 0.0176 | 0.0969 | 0.1242 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0571 | 0.406 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1048 | 0.7799 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0259 | 0.162 | 0.1524 |
Brugia malayi | MAP kinase sur-1 | 0.0571 | 0.406 | 0.3992 |
Brugia malayi | AMP-binding enzyme family protein | 0.0655 | 0.4721 | 0.4661 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0745 | 0.5423 | 0.6954 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0701 | 0.5082 | 0.6458 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0259 | 0.162 | 0.1776 |
Loa Loa (eye worm) | hypothetical protein | 0.1178 | 0.8816 | 1 |
Toxoplasma gondii | type I fatty acid synthase | 0.0108 | 0.0433 | 0.0571 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0745 | 0.5423 | 0.6903 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0176 | 0.0969 | 0.2167 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0176 | 0.0969 | 0.2167 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0745 | 0.5423 | 0.6897 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0176 | 0.0969 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0464 | 0.3222 | 0.4132 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0167 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0745 | 0.5423 | 0.6954 |
Plasmodium vivax | hypothetical protein, conserved | 0.0109 | 0.0446 | 0.3656 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0584 | 0.4167 | 0.5264 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Mycobacterium ulcerans | polyketide synthase MbtC | 0.0176 | 0.0969 | 0.1242 |
Schistosoma mansoni | 3-oxoacyl-[ACP] synthase | 0.0176 | 0.0969 | 0.2167 |
Toxoplasma gondii | acyl carrier protein ACP | 0.0071 | 0.0145 | 0.0028 |
Mycobacterium tuberculosis | Probable polyketide beta-ketoacyl synthase Pks3 | 0.0108 | 0.0433 | 0.0394 |
Toxoplasma gondii | melibiase subfamily protein | 0.0116 | 0.0501 | 0.0701 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.0978 | 0.2191 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0564 | 0.4009 | 0.5141 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0701 | 0.5082 | 0.6451 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium ulcerans | fatty-acid-CoA ligase FadD9 | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0108 | 0.0433 | 0.0394 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0071 | 0.0145 | 0.0019 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0293 | 0.1887 | 0.1794 |
Treponema pallidum | acyl carrier protein | 0.0071 | 0.0145 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.068 | 0.4914 | 0.6238 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.007 | 0.0135 | 0.0054 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0071 | 0.0145 | 0.0186 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.071 | 0.1511 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0701 | 0.5082 | 0.6517 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.013 | 0.0043 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.0145 | 0.0186 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0464 | 0.3222 | 0.402 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0145 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.013 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0145 | 0.008 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1048 | 0.7799 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1048 | 0.7799 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1048 | 0.7799 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0745 | 0.5423 | 0.6954 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0701 | 0.5082 | 0.6451 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0154 | 0.08 | 0.1739 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0176 | 0.0969 | 1 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase | 0.0071 | 0.0145 | 0.0186 |
Echinococcus granulosus | NADH dehydrogenase | 0.0071 | 0.0145 | 0.008 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0216 | 0.1279 | 0.1498 |
Toxoplasma gondii | aminotransferase, putative | 0.0385 | 0.2603 | 0.4672 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.1097 | 0.2329 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.007 | 0.0135 | 0.0054 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0745 | 0.5423 | 0.6903 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0433 | 0.0419 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0564 | 0.4009 | 0.5049 |
Echinococcus multilocularis | AMP dependent ligase | 0.0071 | 0.0145 | 0.008 |
Schistosoma mansoni | methyltransferase-related | 0.0211 | 0.1245 | 0.2866 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.2667 | 0.2973 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.1887 | 0.4373 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0198 | 0.015 |
Echinococcus granulosus | GPCR family 2 | 0.0082 | 0.0232 | 0.0302 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.022 | 0.1315 | 0.1546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 93 uM | Cytotoxicity against human HepG2 cells assessed as NADH level after overnight incubation by MTS assay | ChEMBL. | 22537683 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 22 hrs by broth microdilution method | ChEMBL. | 22537683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.