Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5364 | 0.5364 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5364 | 0.5364 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0327 | 0.5364 | 0.5364 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5364 | 0.5364 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0339 | 0.5731 | 1 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0478 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0327 | 0.5364 | 0.5364 |
Schistosoma mansoni | protein kinase | 0.034 | 0.5746 | 0.0823 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.034 | 0.5746 | 0.5746 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5364 | 0.5364 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.034 | 0.5746 | 0.5746 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.034 | 0.5746 | 0.5746 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0478 | 1 | 1 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0478 | 1 | 1 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0339 | 0.5731 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.0478 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.