Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcitonin receptor-like | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | calcitonin receptor-like | 461 aa | 434 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nervana 2 | 0.0475 | 0.6181 | 0.8984 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.2942 | 0.4493 |
Brugia malayi | Protein kinase domain containing protein | 0.0248 | 0.2942 | 0.2942 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0501 | 0.6548 | 0.5109 |
Trichomonas vaginalis | AGC family protein kinase | 0.0743 | 1 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0475 | 0.6181 | 0.8984 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.2942 | 0.2942 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.2942 | 0.0107 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0271 | 0.0271 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0501 | 0.6548 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0475 | 0.6181 | 0.8984 |
Trichomonas vaginalis | AGC family protein kinase | 0.0268 | 0.3232 | 0.0514 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.2942 | 0.0107 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0271 | 0.0271 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.2942 | 0.4493 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0481 | 0.6258 | 0.5 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0743 | 1 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.0475 | 0.6181 | 0.8984 |
Trichomonas vaginalis | AGC family protein kinase | 0.0743 | 1 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0248 | 0.2942 | 0.2942 |
Entamoeba histolytica | protein kinase, putative | 0.0743 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0248 | 0.2942 | 0.2942 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0481 | 0.6258 | 0.9195 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0271 | 0.0271 |
Trichomonas vaginalis | AGC family protein kinase | 0.0248 | 0.2942 | 0.0107 |
Trichomonas vaginalis | AGC family protein kinase | 0.0743 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0743 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.2942 | 0.4493 |
Echinococcus granulosus | nervana 2 | 0.0475 | 0.6181 | 0.8984 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.2942 | 0.4493 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0501 | 0.6548 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0723 | 0.971 | 0.971 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0248 | 0.2942 | 0.2942 |
Trypanosoma cruzi | Protein kinase B | 0.0501 | 0.6548 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0248 | 0.2942 | 0.2942 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0481 | 0.6258 | 0.9195 |
Brugia malayi | Hr1 repeat family protein | 0.0248 | 0.2942 | 0.2942 |
Brugia malayi | Protein kinase domain containing protein | 0.0248 | 0.2942 | 0.2942 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.2942 | 0.4493 |
Entamoeba histolytica | protein kinase 2, putative | 0.0481 | 0.6258 | 0.4697 |
Giardia lamblia | Kinase, AGC PKA | 0.0481 | 0.6258 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0743 | 1 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0501 | 0.6548 | 0.5109 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0475 | 0.6181 | 0.8984 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0248 | 0.2942 | 0.2942 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0475 | 0.6181 | 0.8984 |
Entamoeba histolytica | protein kinase, putative | 0.0723 | 0.971 | 0.9589 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0475 | 0.6181 | 0.8984 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0501 | 0.6548 | 1 |
Toxoplasma gondii | AGC kinase | 0.0723 | 0.971 | 0.5 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0248 | 0.2942 | 0.2942 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0271 | 0.0271 |
Schistosoma mansoni | serine/threonine kinase | 0.0248 | 0.2942 | 0.4493 |
Schistosoma mansoni | atypical protein kinase C | 0.0248 | 0.2942 | 0.4493 |
Brugia malayi | protein kinase C II. | 0.0248 | 0.2942 | 0.2942 |
Trichomonas vaginalis | AGC family protein kinase | 0.0743 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0723 | 0.971 | 0.971 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.2942 | 0.4493 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0743 | 1 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0481 | 0.6258 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0743 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0501 | 0.6548 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0743 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.2942 | 0.4493 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0481 | 0.6258 | 0.9195 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0501 | 0.6548 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 97 nM | Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting | ChEMBL. | 22429471 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.