Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.1255 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0361 | 0.2704 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.1255 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.1255 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.1255 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0361 | 0.2704 | 0.5 |
Echinococcus multilocularis | 0.0361 | 0.2704 | 1 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.1255 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0361 | 0.2704 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0361 | 0.2704 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0075 | 0.0371 | 0.0776 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0361 | 0.2704 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0361 | 0.2704 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0361 | 0.2704 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0361 | 0.2704 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.1255 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0061 | 0.0256 | 0.0256 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.0175 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0371 | 0.0118 |
Brugia malayi | cytochrome P450 | 0.0361 | 0.2704 | 0.2704 |
Loa Loa (eye worm) | hypothetical protein | 0.0894 | 0.7053 | 0.6976 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0361 | 0.2704 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0075 | 0.0371 | 0.0776 |
Loa Loa (eye worm) | cytochrome P450 | 0.0361 | 0.2704 | 0.2512 |
Trypanosoma brucei | cytochrome P450, putative | 0.1255 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0361 | 0.2704 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0361 | 0.2704 | 0.2704 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0055 | 0.0209 | 0.0209 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0361 | 0.2704 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0361 | 0.2704 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0361 | 0.2704 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0361 | 0.2704 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0361 | 0.2704 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0361 | 0.2704 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0361 | 0.2704 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0361 | 0.2704 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0069 | 0.0324 | 0.1198 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0361 | 0.2704 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0361 | 0.2704 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.1255 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0361 | 0.2704 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.1255 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0361 | 0.2704 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0361 | 0.2704 | 0.2704 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0361 | 0.2704 | 0.2512 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0361 | 0.2704 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0361 | 0.2704 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0361 | 0.2704 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0361 | 0.2704 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 950 nM | Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization by FLIPR analysis | ChEMBL. | 22465637 |
Emax (binding) | = 82 % | Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization by FLIPR analysis relative to PHCCC | ChEMBL. | 22465637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.