Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | 0.0742 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0742 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0742 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0742 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0663 | 0.6278 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0663 | 0.6278 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0663 | 0.6278 | 0.6278 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0663 | 0.6278 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0742 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0742 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0663 | 0.6278 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0742 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0742 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0663 | 0.6278 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0663 | 0.6278 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0742 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.