Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.7251 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2831 | 0.3396 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.7251 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.7251 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.7251 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2831 | 0.3396 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.7251 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.7251 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.7251 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2831 | 0.3396 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2831 | 0.3396 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2831 | 0.3396 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.2831 | 0.3396 | 0.3396 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.2831 | 0.3396 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2831 | 0.3396 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.7251 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.2831 | 0.3396 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.7251 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.7251 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.7251 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.7251 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.7251 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2831 | 0.3396 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2831 | 0.3396 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.7251 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2831 | 0.3396 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 7 % | Displacement of [3H]-mesulergine from 5HT2C receptor expressed in CHO cell membranes at 1 uM after 90 mins by scintillation counting | ChEMBL. | 22381048 |
Inhibition (binding) | = 16 % | Displacement of [3H]-mesulergine from 5HT2C receptor expressed in CHO cell membranes at 10 uM after 90 mins by scintillation counting | ChEMBL. | 22381048 |
Ki (binding) | > 10000 nM | Displacement of [3H]-mesulergine from 5HT2C receptor expressed in CHO cell membranes after 90 mins by scintillation counting | ChEMBL. | 22381048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.