TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 300.349 | Formula: C18H20O4
H donors: 2 H acceptors: 3 LogP: 2.33 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OCC(OC(=O)Cc1ccc(cc1)Cc1ccccc1)CO
InChi: 1S/C18H20O4/c19-12-17(13-20)22-18(21)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17,19-20H,10-13H2
InChiKey: IWKDZKAHQXMICO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Monoglyceride lipase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	valacyclovir hydrolase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania mexicana	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania braziliensis	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium vivax	PST-A protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania major	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	esterase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium tuberculosis	Possible lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania infantum	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma cruzi	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania donovani	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	Get druggable targets OG5_127037	All targets in OG5_127037

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium knowlesi	lysophospholipase, putative	Monoglyceride lipase	303 aa	280 aa	23.2 %
Babesia bovis	lysophospholipase, putative	Monoglyceride lipase	303 aa	289 aa	22.8 %
Candida albicans	similar to S. cerevisiae YOR084W	Monoglyceride lipase	303 aa	303 aa	23.4 %
Neospora caninum	Lysophospholipase, related	Monoglyceride lipase	303 aa	380 aa	21.1 %
Plasmodium vivax	unspecified product	Monoglyceride lipase	303 aa	274 aa	23.4 %
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	Monoglyceride lipase	303 aa	245 aa	23.3 %
Plasmodium vivax	PST-A protein	Monoglyceride lipase	303 aa	257 aa	21.0 %
Plasmodium berghei	alpha/beta hydrolase, putative	Monoglyceride lipase	303 aa	284 aa	20.4 %
Plasmodium vivax	hypothetical protein, conserved	Monoglyceride lipase	303 aa	282 aa	20.6 %
Toxoplasma gondii	phospholipase	Monoglyceride lipase	303 aa	378 aa	20.9 %
Plasmodium knowlesi	alpha/beta hydrolase, putative	Monoglyceride lipase	303 aa	261 aa	21.5 %
Plasmodium vivax	PST-A protein	Monoglyceride lipase	303 aa	261 aa	24.1 %
Plasmodium falciparum	esterase, putative	Monoglyceride lipase	303 aa	273 aa	19.0 %
Plasmodium knowlesi	lysophospholipase, putative	Monoglyceride lipase	303 aa	250 aa	22.4 %
Candida albicans	similar to S. cerevisiae YOR084W	Monoglyceride lipase	303 aa	303 aa	23.4 %
Trypanosoma brucei	Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative	Monoglyceride lipase	303 aa	276 aa	23.2 %
Mycobacterium ulcerans	hydrolase	Monoglyceride lipase	303 aa	284 aa	22.5 %
Plasmodium berghei	prodrug activation and resistance esterase, putative	Monoglyceride lipase	303 aa	266 aa	22.9 %
Plasmodium knowlesi	esterase, putative	Monoglyceride lipase	303 aa	259 aa	25.5 %
Plasmodium knowlesi	conserved Plasmodium protein, unknown function	Monoglyceride lipase	303 aa	272 aa	20.2 %
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	Monoglyceride lipase	303 aa	250 aa	21.2 %
Plasmodium vivax	lysophospholipase, putative	Monoglyceride lipase	303 aa	274 aa	23.4 %
Plasmodium falciparum	esterase, putative	Monoglyceride lipase	303 aa	265 aa	21.5 %
Plasmodium falciparum	epoxide hydrolase 2	Monoglyceride lipase	303 aa	254 aa	22.4 %
Mycobacterium tuberculosis	Possible hydrolase	Monoglyceride lipase	303 aa	263 aa	23.2 %
Leishmania braziliensis	hypothetical protein, conserved	Monoglyceride lipase	303 aa	250 aa	24.8 %
Plasmodium vivax	lysophospholipase, putative	Monoglyceride lipase	303 aa	361 aa	21.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0019	0.0802	0.0553
Loa Loa (eye worm)	acyl carrier protein	0.001	0.0137	0.0137
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0016	0.0597	0.0933
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0041	0.2589	0.2589
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0982	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2883	0.2883
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0084	0.6031	0.5
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0014	0.0473	0.3373
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0018	0.0751	0.0461
Echinococcus multilocularis	muscleblind protein 1	0.0134	1	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Mycobacterium ulcerans	hypothetical protein	0.0084	0.6031	1
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0011	0.0218	0.1555
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0042	0.2693	0.2693
Toxoplasma gondii	type I fatty acid synthase, putative	0.0016	0.0586	0.4174
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.0982	0.1574
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0018	0.0751	0.0461
Mycobacterium ulcerans	thioesterase	0.0019	0.0802	0.0553
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0032	0.1842	0.3883
Loa Loa (eye worm)	PHD-finger family protein	0.0026	0.1403	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1755	0.1755
Leishmania major	monoglyceride lipase, putative	0.0084	0.6031	0.5
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0022	0.1099	0.1769
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0026	0.1403	0.1002
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0024	0.1209	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2893	0.2893
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0018	0.0751	0.0461
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.6031	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.2589	0.5459
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1403	0.1403
Echinococcus multilocularis	muscleblind protein	0.0134	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0316	0.0316
Brugia malayi	PHD-finger family protein	0.0026	0.1403	0.1403
Mycobacterium ulcerans	polyketide synthase	0.0022	0.1099	0.1089
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0022	0.1099	0.1769
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0033	0.1979	0.3238
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0026	0.1403	0.2959
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0982	0.0982
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0045	0.2883	0.2883
Loa Loa (eye worm)	hypothetical protein	0.0134	1	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.2589	0.5459
Loa Loa (eye worm)	jmjC domain-containing protein	0.0054	0.3623	0.3623
Schistosoma mansoni	hypothetical protein	0.0014	0.0447	0.0941
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0013	0.0331	0.0487
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0014	0.0447	0.0447
Schistosoma mansoni	hypothetical protein	0.0014	0.0447	0.0941
Trypanosoma cruzi	monoglyceride lipase, putative	0.0084	0.6031	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.0032	0.1842	0.1842
Toxoplasma gondii	PHD-finger domain-containing protein	0.0026	0.1403	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0026	0.1403	0.1002
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0014	0.0447	0.0447
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0032	0.1842	0.3883
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0022	0.1099	0.1089
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0019	0.0802	0.1274
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0024	0.1209	0.1954
Schistosoma mansoni	jumonji domain containing protein	0.0068	0.4743	1
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.6031	1
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.6031	0.5
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0022	0.1099	0.1089
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.1403	0.2327
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	0.6031	1
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	0.6031	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.2309	0.2309
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0033	0.1979	0.3238
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0024	0.1209	0.1954
Brugia malayi	jmjC domain containing protein	0.0086	0.6146	0.6146
Echinococcus granulosus	peregrin	0.0026	0.1403	0.1002
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0084	0.6031	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0045	0.2883	0.2883
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0022	0.1099	0.1089
Schistosoma mansoni	hypothetical protein	0.0026	0.1403	0.2959
Brugia malayi	Latrophilin receptor protein 2	0.0014	0.0447	0.0447
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0041	0.2589	0.2589
Mycobacterium ulcerans	polyketide synthase Pks13	0.0033	0.1979	0.268
Echinococcus multilocularis	jumonji domain containing protein	0.0036	0.222	0.1856
Loa Loa (eye worm)	fatty acid synthase	0.0022	0.1075	0.1075
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0024	0.1209	0.1954
Plasmodium falciparum	phd finger protein, putative	0.0026	0.1403	0.2327
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0022	0.1099	0.1099
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0022	0.1099	0.1769
Schistosoma mansoni	hypothetical protein	0.0014	0.0447	0.0941
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0024	0.1209	0.1289
Echinococcus granulosus	lysine specific demethylase 5A	0.0032	0.1842	0.1461
Mycobacterium ulcerans	thioesterase TesA	0.0019	0.0802	0.0553
Onchocerca volvulus		0.0039	0.2417	0.9285
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0447	0.0447
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.6031	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0022	0.1099	0.1089
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0086	0.6146	0.5966
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.2589	0.5459
Brugia malayi	latrophilin 2 splice variant baaae	0.0031	0.1755	0.1755
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0022	0.1044	0.1678
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0041	0.2589	0.2243
Echinococcus multilocularis	peregrin	0.0026	0.1403	0.1002
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0022	0.1099	0.1089
Onchocerca volvulus	Alhambra homolog	0.0026	0.1403	0.2727
Mycobacterium ulcerans	polyketide synthase	0.0024	0.1209	0.1289
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0024	0.1209	0.1289
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0041	0.2589	0.2243
Echinococcus granulosus	muscleblind protein	0.0134	1	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0022	0.1099	0.1089
Mycobacterium tuberculosis	Possible lysophospholipase	0.0084	0.6031	1
Toxoplasma gondii	type I fatty acid synthase, putative	0.0024	0.1209	0.8617
Schistosoma mansoni	hypothetical protein	0.0014	0.0447	0.0941
Giardia lamblia	PHD finger protein 15	0.0026	0.1403	0.5
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0084	0.6031	1
Brugia malayi	Bromodomain containing protein	0.0026	0.1403	0.1403
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0045	0.2883	0.2883
Echinococcus multilocularis	lysine specific demethylase 5A	0.0032	0.1842	0.1461
Plasmodium falciparum	esterase, putative	0.0084	0.6031	1
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.6031	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0041	0.2589	0.2243
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0018	0.0774	0.1228
Echinococcus granulosus	jumonji domain containing protein	0.0036	0.222	0.1856
Plasmodium vivax	PST-A protein	0.0084	0.6031	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0022	0.1044	0.1678
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0041	0.2589	0.2243
Schistosoma mansoni	hypothetical protein	0.0031	0.1755	0.3701
Toxoplasma gondii	PHD-finger domain-containing protein	0.0026	0.1403	1
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0024	0.1209	0.1289
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0084	0.6031	0.5
Mycobacterium ulcerans	lysophospholipase	0.0084	0.6031	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0086	0.6146	0.5966
Mycobacterium leprae	Polyketide synthase Pks13	0.0033	0.1979	0.268
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0024	0.1209	0.1289
Onchocerca volvulus	Fatty acid synthase homolog	0.004	0.2527	1
Brugia malayi	jmjC domain containing protein	0.0032	0.1842	0.1842
Loa Loa (eye worm)	hypothetical protein	0.0134	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 4	Inhibition of rat brain membrane FAAH assessed as [3H]-anandamide hydrolysis after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522
IC50 (binding)	= 6.15	Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522
IC50 (binding)	= 0.7 uM	Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522
IC50 (binding)	> 100 uM	Inhibition of rat brain membrane FAAH assessed as [3H]-anandamide hydrolysis after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522
Inhibition (binding)	< 10 %	Inhibition of human recombinant his-tagged MAGL expressed in Escherichia coli assessed as hydrolysis of 4-nitrophenyl acetate at 10 uM after 20 mins by microplate reader	ChEMBL.	22185522
Inhibition (binding)	= 49 %	Inhibition of rat brain membrane FAAH assessed as [3H]-anandamide hydrolysis at 100 uM after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2011482

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1642416