TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 300.349 | Formula: C18H20O4
H donors: 2 H acceptors: 3 LogP: 2.33 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OCC(OC(=O)Cc1ccc(cc1)Cc1ccccc1)CO
InChi: 1S/C18H20O4/c19-12-17(13-20)22-18(21)11-16-8-6-15(7-9-16)10-14-4-2-1-3-5-14/h1-9,17,19-20H,10-13H2
InChiKey: IWKDZKAHQXMICO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Monoglyceride lipase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium tuberculosis	Possible lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	valacyclovir hydrolase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium vivax	PST-A protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania mexicana	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania major	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania infantum	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma cruzi	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania donovani	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania braziliensis	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	esterase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	epoxide hydrolase 2	Monoglyceride lipase	303 aa	254 aa	22.4 %
Candida albicans	similar to S. cerevisiae YOR084W	Monoglyceride lipase	303 aa	303 aa	23.4 %
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	Monoglyceride lipase	303 aa	250 aa	21.2 %
Plasmodium knowlesi	lysophospholipase, putative	Monoglyceride lipase	303 aa	280 aa	23.2 %
Plasmodium berghei	prodrug activation and resistance esterase, putative	Monoglyceride lipase	303 aa	266 aa	22.9 %
Neospora caninum	Lysophospholipase, related	Monoglyceride lipase	303 aa	380 aa	21.1 %
Mycobacterium tuberculosis	Possible hydrolase	Monoglyceride lipase	303 aa	263 aa	23.2 %
Trypanosoma brucei	Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative	Monoglyceride lipase	303 aa	276 aa	23.2 %
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	Monoglyceride lipase	303 aa	245 aa	23.3 %
Plasmodium knowlesi	esterase, putative	Monoglyceride lipase	303 aa	259 aa	25.5 %
Leishmania braziliensis	hypothetical protein, conserved	Monoglyceride lipase	303 aa	250 aa	24.8 %
Plasmodium vivax	lysophospholipase, putative	Monoglyceride lipase	303 aa	361 aa	21.6 %
Toxoplasma gondii	phospholipase	Monoglyceride lipase	303 aa	378 aa	20.9 %
Babesia bovis	lysophospholipase, putative	Monoglyceride lipase	303 aa	289 aa	22.8 %
Plasmodium berghei	alpha/beta hydrolase, putative	Monoglyceride lipase	303 aa	284 aa	20.4 %
Candida albicans	similar to S. cerevisiae YOR084W	Monoglyceride lipase	303 aa	303 aa	23.4 %
Plasmodium vivax	PST-A protein	Monoglyceride lipase	303 aa	257 aa	21.0 %
Plasmodium knowlesi	conserved Plasmodium protein, unknown function	Monoglyceride lipase	303 aa	272 aa	20.2 %
Plasmodium vivax	lysophospholipase, putative	Monoglyceride lipase	303 aa	274 aa	23.4 %
Plasmodium vivax	unspecified product	Monoglyceride lipase	303 aa	274 aa	23.4 %
Mycobacterium ulcerans	hydrolase	Monoglyceride lipase	303 aa	284 aa	22.5 %
Plasmodium vivax	hypothetical protein, conserved	Monoglyceride lipase	303 aa	282 aa	20.6 %
Plasmodium falciparum	esterase, putative	Monoglyceride lipase	303 aa	265 aa	21.5 %
Plasmodium falciparum	esterase, putative	Monoglyceride lipase	303 aa	273 aa	19.0 %
Plasmodium knowlesi	lysophospholipase, putative	Monoglyceride lipase	303 aa	250 aa	22.4 %
Plasmodium knowlesi	alpha/beta hydrolase, putative	Monoglyceride lipase	303 aa	261 aa	21.5 %
Plasmodium vivax	PST-A protein	Monoglyceride lipase	303 aa	261 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	polyketide synthase	0.0024	0.1209	0.1289
Loa Loa (eye worm)	jmjC domain-containing protein	0.0054	0.3623	0.3623
Mycobacterium ulcerans	polyketide synthase	0.0022	0.1099	0.1089
Brugia malayi	jmjC domain containing protein	0.0032	0.1842	0.1842
Onchocerca volvulus		0.0039	0.2417	0.9285
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0022	0.1099	0.1769
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0019	0.0802	0.1274
Schistosoma mansoni	hypothetical protein	0.0014	0.0447	0.0941
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0982	0.0982
Mycobacterium ulcerans	thioesterase	0.0019	0.0802	0.0553
Toxoplasma gondii	type I fatty acid synthase, putative	0.0016	0.0586	0.4174
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0022	0.1099	0.1089
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0018	0.0751	0.0461
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0022	0.1044	0.1678
Brugia malayi	Latrophilin receptor protein 2	0.0014	0.0447	0.0447
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0024	0.1209	0.1289
Trypanosoma cruzi	monoglyceride lipase, putative	0.0084	0.6031	0.5
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0022	0.1099	0.1089
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0026	0.1403	0.1002
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0022	0.1099	0.1089
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0024	0.1209	0.1954
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	0.6031	1
Toxoplasma gondii	type I fatty acid synthase, putative	0.0024	0.1209	0.8617
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.0982	0.1574
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0084	0.6031	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.2589	0.5459
Plasmodium falciparum	phd finger protein, putative	0.0026	0.1403	0.2327
Echinococcus granulosus	lysine specific demethylase 5A	0.0032	0.1842	0.1461
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2893	0.2893
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.6031	0.5
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0316	0.0316
Onchocerca volvulus	Fatty acid synthase homolog	0.004	0.2527	1
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0033	0.1979	0.3238
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0084	0.6031	0.5
Echinococcus granulosus	PHD finger protein rhinoceros	0.0026	0.1403	0.1002
Plasmodium falciparum	esterase, putative	0.0084	0.6031	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0041	0.2589	0.2243
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0014	0.0447	0.0447
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0011	0.0218	0.1555
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0032	0.1842	0.3883
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.6031	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0013	0.0331	0.0487
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Schistosoma mansoni	hypothetical protein	0.0014	0.0447	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1755	0.1755
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2883	0.2883
Mycobacterium ulcerans	polyketide synthase Pks13	0.0033	0.1979	0.268
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0018	0.0751	0.0461
Echinococcus multilocularis	peregrin	0.0026	0.1403	0.1002
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0032	0.1842	0.3883
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0024	0.1209	0.1289
Giardia lamblia	PHD finger protein 15	0.0026	0.1403	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0022	0.1099	0.1769
Brugia malayi	jmjC domain containing protein	0.0086	0.6146	0.6146
Mycobacterium leprae	Polyketide synthase Pks13	0.0033	0.1979	0.268
Plasmodium vivax	PST-A protein	0.0084	0.6031	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0016	0.0597	0.0933
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0014	0.0473	0.3373
Mycobacterium ulcerans	lysophospholipase	0.0084	0.6031	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.2589	0.5459
Schistosoma mansoni	hypothetical protein	0.0014	0.0447	0.0941
Onchocerca volvulus	Alhambra homolog	0.0026	0.1403	0.2727
Schistosoma mansoni	hypothetical protein	0.0031	0.1755	0.3701
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0041	0.2589	0.2589
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0022	0.1099	0.1769
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0084	0.6031	1
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.6031	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0447	0.0941
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0026	0.1403	0.2959
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0447	0.0447
Loa Loa (eye worm)	acyl carrier protein	0.001	0.0137	0.0137
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	0.6031	1
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0022	0.1099	0.1089
Echinococcus granulosus	jumonji domain containing protein	0.0036	0.222	0.1856
Echinococcus multilocularis	lysine specific demethylase 5A	0.0032	0.1842	0.1461
Mycobacterium ulcerans	thioesterase TesA	0.0019	0.0802	0.0553
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.6031	0.5
Leishmania major	monoglyceride lipase, putative	0.0084	0.6031	0.5
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0018	0.0751	0.0461
Toxoplasma gondii	PHD-finger domain-containing protein	0.0026	0.1403	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0041	0.2589	0.2243
Plasmodium falciparum	lysophospholipase, putative	0.0084	0.6031	1
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0024	0.1209	0.1954
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0041	0.2589	0.2589
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0086	0.6146	0.5966
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0022	0.1044	0.1678
Brugia malayi	Bromodomain containing protein	0.0026	0.1403	0.1403
Loa Loa (eye worm)	PHD-finger family protein	0.0026	0.1403	0.1403
Echinococcus multilocularis	muscleblind protein 1	0.0134	1	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0026	0.1403	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.2309	0.2309
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0018	0.0774	0.1228
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0041	0.2589	0.2243
Loa Loa (eye worm)	jmjC domain-containing protein	0.0032	0.1842	0.1842
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0045	0.2883	0.2883
Echinococcus granulosus	muscleblind protein	0.0134	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0031	0.1755	0.1755
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0086	0.6146	0.5966
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0022	0.1099	0.1089
Echinococcus multilocularis	jumonji domain containing protein	0.0036	0.222	0.1856
Echinococcus multilocularis	muscleblind protein	0.0134	1	1
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0084	0.6031	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0014	0.0447	0.0447
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0019	0.0802	0.0553
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0024	0.1209	0.1289
Brugia malayi	PHD-finger family protein	0.0026	0.1403	0.1403
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0022	0.1099	0.1089
Loa Loa (eye worm)	fatty acid synthase	0.0022	0.1075	0.1075
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0982	0.0982
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0024	0.1209	0.1289
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0024	0.1209	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1403	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0134	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0045	0.2883	0.2883
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0041	0.2589	0.5459
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.1403	0.2327
Echinococcus granulosus	peregrin	0.0026	0.1403	0.1002
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0024	0.1209	0.1954
Mycobacterium tuberculosis	Possible lysophospholipase	0.0084	0.6031	1
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0033	0.1979	0.3238
Schistosoma mansoni	hypothetical protein	0.0026	0.1403	0.2959
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	0.6031	0.5
Mycobacterium ulcerans	hypothetical protein	0.0084	0.6031	1
Schistosoma mansoni	jumonji domain containing protein	0.0068	0.4743	1
Loa Loa (eye worm)	hypothetical protein	0.0134	1	1
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0022	0.1099	0.1099
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0041	0.2589	0.2243
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0045	0.2883	0.2883
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0042	0.2693	0.2693

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 4	Inhibition of rat brain membrane FAAH assessed as [3H]-anandamide hydrolysis after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522
IC50 (binding)	= 6.15	Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522
IC50 (binding)	= 0.7 uM	Inhibition of rat brain cytosolic MAGL assessed as [3H]-2-arachidonoyl glycerol hydrolysis after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522
IC50 (binding)	> 100 uM	Inhibition of rat brain membrane FAAH assessed as [3H]-anandamide hydrolysis after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522
Inhibition (binding)	< 10 %	Inhibition of human recombinant his-tagged MAGL expressed in Escherichia coli assessed as hydrolysis of 4-nitrophenyl acetate at 10 uM after 20 mins by microplate reader	ChEMBL.	22185522
Inhibition (binding)	= 49 %	Inhibition of rat brain membrane FAAH assessed as [3H]-anandamide hydrolysis at 100 uM after 10 mins by liquid scintillation spectroscopy	ChEMBL.	22185522

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2011482

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1642416