Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 7 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 502 aa | 513 aa | 33.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxyl transferase domain containing protein | 0.0336 | 0.9606 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0132 | 0.3035 | 0.2839 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0215 | 0.5715 | 1 |
Toxoplasma gondii | pyruvate carboxylase | 0.0132 | 0.3035 | 0.2839 |
Leishmania major | carboxylase, putative | 0.0132 | 0.3035 | 0.2839 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0059 | 0.0668 | 0.5 |
Schistosoma mansoni | pyruvate carboxylase | 0.0132 | 0.3035 | 0.2839 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0059 | 0.0668 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0132 | 0.3035 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0348 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0323 | 0.005 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.019 | 0.0198 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0252 | 0.6891 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2001 | 0.2083 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0095 | 0.5 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0348 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0132 | 0.3035 | 1 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0132 | 0.3035 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0095 | 0.5 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0336 | 0.9606 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.0047 | 0.0274 | 0.0085 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0132 | 0.3035 | 0.2839 |
Chlamydia trachomatis | biotin carboxylase | 0.012 | 0.2641 | 1 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0132 | 0.3035 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0132 | 0.3035 | 1 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0132 | 0.3035 | 0.29 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0132 | 0.3035 | 0.2839 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0132 | 0.3035 | 0.2839 |
Trypanosoma brucei | unspecified product | 0.0087 | 0.1567 | 0.1329 |
Onchocerca volvulus | 0.0101 | 0.2001 | 0.5 | |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0348 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 0.2001 | 0.5 | |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0132 | 0.3035 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 0.2001 | 0.1776 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0132 | 0.3035 | 0.2839 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0323 | 0.005 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0132 | 0.3035 | 0.5074 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0132 | 0.3035 | 1 |
Onchocerca volvulus | 0.0101 | 0.2001 | 0.5 | |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0132 | 0.3035 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2001 | 0.2083 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0132 | 0.3035 | 0.5074 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.0047 | 0.0274 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1776 | 0.1849 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0132 | 0.3035 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0348 | 1 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0252 | 0.6891 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0101 | 0.2001 | 0.1923 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0348 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 0.2001 | 0.1776 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6.5 | Agonist activity at human alpha7 nAChR expressed in GH4C1 cells by FLIPR assay | ChEMBL. | 22503248 |
IC50 (binding) | = 5.1 | Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assay | ChEMBL. | 22503248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.