Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1225 | 0.2691 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.0316 | 0.0316 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0114 | 0.1225 | 0.1225 |
Echinococcus granulosus | lamin dm0 | 0.0022 | 0.0108 | 0.0108 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0168 | 0.825 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.048 | 0.1672 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.048 | 0.048 |
Brugia malayi | beta-lactamase | 0.003 | 0.0204 | 0.045 |
Brugia malayi | MAP kinase sur-1 | 0.0248 | 0.2868 | 0.6335 |
Onchocerca volvulus | 0.0027 | 0.0168 | 0.0494 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0083 | 0.0163 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0168 | 0.825 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0168 | 0.825 |
Leishmania major | trypanothione reductase | 0.0039 | 0.0316 | 0.11 |
Loa Loa (eye worm) | beta-lactamase | 0.003 | 0.0204 | 0.043 |
Echinococcus granulosus | expressed conserved protein | 0.0107 | 0.1141 | 0.1141 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.01 | 0.1057 | 0.4799 |
Echinococcus granulosus | lamin | 0.0022 | 0.0108 | 0.0108 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0168 | 0.0763 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0383 | 0.4528 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.0316 | 0.11 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0168 | 0.825 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.009 | 0.0934 | 0.8617 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0049 | 0.043 | 0.043 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.0316 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0026 | 0.0153 | 0.0153 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0022 | 0.0108 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0204 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0189 | 0.0398 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0248 | 0.2868 | 0.2868 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.003 | 0.0204 | 0.0924 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0102 | 0.1081 | 0.2388 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0189 | 0.066 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0083 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.003 | 0.0204 | 0.0924 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0153 | 0.0532 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0163 | 0.1823 | 0.1823 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.003 | 0.0204 | 0.071 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.253 | 0.5578 |
Brugia malayi | intermediate filament protein | 0.0022 | 0.0108 | 0.0239 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0026 | 0.0153 | 0.0316 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.007 | 0.0316 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0248 | 0.2868 | 1 |
Echinococcus multilocularis | Smad4 | 0.0026 | 0.0153 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.1081 | 0.3769 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.003 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.043 | 0.0931 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0153 | 0.0532 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0204 | 0.071 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.003 | 0.0204 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.003 | 0.0204 | 0.0924 |
Onchocerca volvulus | 0.003 | 0.0204 | 0.0788 | |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.1081 | 0.3769 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0163 | 0.1823 | 0.1823 |
Echinococcus multilocularis | GPCR, family 2 | 0.0102 | 0.1081 | 0.1081 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0248 | 0.2868 | 1 |
Schistosoma mansoni | smad | 0.0026 | 0.0153 | 0.0532 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.003 | 0.0204 | 0.071 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.0316 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0083 | 0.0163 |
Brugia malayi | CHE-14 protein | 0.0049 | 0.043 | 0.095 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.0316 | 0.11 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0026 | 0.0153 | 0.0532 |
Mycobacterium tuberculosis | Conserved protein | 0.003 | 0.0204 | 0.0924 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1081 | 0.2371 |
Echinococcus granulosus | intermediate filament protein | 0.0022 | 0.0108 | 0.0108 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0102 | 0.1081 | 0.1081 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.003 | 0.0204 | 0.043 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0.0204 | 0.071 |
Echinococcus multilocularis | protein patched | 0.0049 | 0.043 | 0.043 |
Schistosoma mansoni | hypothetical protein | 0.022 | 0.253 | 0.882 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.0316 | 0.0697 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0168 | 0.825 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.003 | 0.0204 | 0.0924 |
Schistosoma mansoni | lamin | 0.0022 | 0.0108 | 0.0377 |
Treponema pallidum | NADH oxidase | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0189 | 0.0418 |
Mycobacterium leprae | Probable lipase LipE | 0.003 | 0.0204 | 0.0401 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0322 | 0.3778 | 0.8344 |
Loa Loa (eye worm) | intermediate filament protein | 0.0022 | 0.0108 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0204 | 0.043 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0102 | 0.1081 | 0.1081 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0168 | 0.0351 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0168 | 0.0586 |
Echinococcus granulosus | smad | 0.0026 | 0.0153 | 0.0153 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0168 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0168 | 0.0351 |
Schistosoma mansoni | Smad4 | 0.0026 | 0.0153 | 0.0532 |
Mycobacterium ulcerans | beta-lactamase | 0.003 | 0.0204 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0026 | 0.0153 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.1321 | 0.2902 |
Brugia malayi | glutathione reductase | 0.0039 | 0.0316 | 0.0697 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0168 | 0.825 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.0316 | 0.1432 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0049 | 0.043 | 0.043 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0409 | 0.1425 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.003 | 0.0204 | 0.071 |
Echinococcus multilocularis | lamin dm0 | 0.0022 | 0.0108 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0409 | 0.1425 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.003 | 0.0204 | 0.071 |
Echinococcus multilocularis | lamin | 0.0022 | 0.0108 | 0.0108 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.003 | 0.0204 | 0.0204 |
Trypanosoma brucei | hypothetical protein, conserved | 0.003 | 0.0204 | 0.071 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.0316 | 0.0677 |
Echinococcus multilocularis | tumor protein p63 | 0.083 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.003 | 0.0204 | 0.071 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.048 | 0.1059 |
Echinococcus granulosus | Smad4 | 0.0026 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.048 | 0.1041 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.003 | 0.0204 | 0.0924 |
Onchocerca volvulus | 0.0122 | 0.1321 | 1 | |
Echinococcus multilocularis | expressed conserved protein | 0.0107 | 0.1141 | 0.1141 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.001 | 0.0021 |
Trichomonas vaginalis | esterase, putative | 0.003 | 0.0204 | 0.071 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0248 | 0.2868 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.009 | 0.0934 | 0.4241 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0248 | 0.2868 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0168 | 0.0371 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0189 | 0.066 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.009 | 0.0934 | 0.4241 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0248 | 0.2868 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0049 | 0.043 | 0.0931 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0383 | 0.4528 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.003 | 0.0204 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0248 | 0.2868 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0102 | 0.1081 | 0.1081 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0194 | 0.2203 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.007 | 0.0316 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0049 | 0.043 | 0.043 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.001 | 0.0021 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0248 | 0.2868 | 0.6327 |
Mycobacterium tuberculosis | Conserved protein | 0.003 | 0.0204 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0204 | 0.043 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.009 | 0.0934 | 0.4241 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0022 | 0.0108 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0204 | 0.043 |
Onchocerca volvulus | 0.003 | 0.0204 | 0.0788 | |
Trypanosoma brucei | protein kinase, putative | 0.0248 | 0.2868 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0248 | 0.2868 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0083 | 0.2638 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0102 | 0.1081 | 0.1081 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0122 | 0.1321 | 0.4605 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0102 | 0.1081 | 0.1081 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0189 | 0.066 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0322 | 0.3778 | 0.8341 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0114 | 0.1225 | 0.2706 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0102 | 0.1081 | 0.2371 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0204 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0083 | 0.0163 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.1081 | 0.3769 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0189 | 0.066 |
Brugia malayi | MH1 domain containing protein | 0.0026 | 0.0153 | 0.0337 |
Schistosoma mansoni | lamin | 0.0022 | 0.0108 | 0.0377 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0409 | 0.1425 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0189 | 0.5996 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.003 | 0.0204 | 0.071 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0114 | 0.1225 | 0.1225 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.003 | 0.0204 | 0.0924 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.0204 | 0.6454 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.048 | 0.048 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0248 | 0.2868 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0083 | 0.2638 |
Echinococcus multilocularis | musashi | 0.0022 | 0.0108 | 0.0108 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.003 | 0.0204 | 0.0924 |
Loa Loa (eye worm) | Smad1 | 0.0026 | 0.0153 | 0.0316 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0168 | 0.0586 |
Brugia malayi | beta-lactamase family protein | 0.003 | 0.0204 | 0.045 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.01 | 0.1057 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0026 | 0.0153 | 0.0337 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0083 | 0.0378 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0248 | 0.2868 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0114 | 0.1225 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.007 | 0.0316 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.048 | 0.048 |
Mycobacterium leprae | conserved hypothetical protein | 0.003 | 0.0204 | 0.0401 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0248 | 0.2868 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.1081 | 0.3769 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0168 | 0.825 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0248 | 0.2868 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.009 | 0.0934 | 0.4241 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0168 | 0.0371 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.043 | 0.15 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0102 | 0.1081 | 0.2388 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.007 | 0.0316 |
Mycobacterium tuberculosis | Probable reductase | 0.009 | 0.0934 | 0.4241 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0565 | 0.1229 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0063 | 0.0139 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.048 | 0.1672 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.0316 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.003 | 0.0204 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0168 | 0.0351 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.01 | 0.1057 | 0.4799 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0103 | 0.0207 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0248 | 0.2868 | 1 |
Schistosoma mansoni | patched 1 | 0.0049 | 0.043 | 0.15 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0168 | 0.825 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.048 | 0.048 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0189 | 0.066 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0248 | 0.2868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.3778 | 0.8341 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0322 | 0.3778 | 0.8344 |
Brugia malayi | MH2 domain containing protein | 0.0383 | 0.4528 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0026 | 0.0153 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0083 | 0.0163 |
Brugia malayi | MH1 domain containing protein | 0.0026 | 0.0153 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0083 | 0.0163 |
Echinococcus multilocularis | protein dispatched 1 | 0.0056 | 0.0515 | 0.0515 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.0316 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0409 | 0.1425 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0153 | 0.0532 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.0316 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0248 | 0.2868 | 1 |
Onchocerca volvulus | 0.003 | 0.0204 | 0.0788 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.003 | 0.0204 | 0.045 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0168 | 0.0763 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.048 | 0.1672 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0026 | 0.0153 | 0.0153 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0168 | 0.0371 |
Brugia malayi | Smad1 | 0.0026 | 0.0153 | 0.0337 |
Mycobacterium ulcerans | hypothetical protein | 0.003 | 0.0204 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.0316 | 0.11 |
Echinococcus multilocularis | smad | 0.0026 | 0.0153 | 0.0153 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.009 | 0.0934 | 0.4241 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0108 | 0.0218 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0189 | 0.5996 |
Mycobacterium tuberculosis | Probable hydrolase | 0.003 | 0.0204 | 0.0924 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0026 | 0.0153 | 0.0153 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0248 | 0.2868 | 0.2868 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0189 | 0.5996 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.022 | 0.253 | 0.5587 |
Schistosoma mansoni | intermediate filament proteins | 0.0022 | 0.0108 | 0.0377 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0026 | 0.0153 | 0.0153 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0115 | 0.1247 | 0.4347 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0204 | 0.043 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0248 | 0.2868 | 0.2868 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.003 | 0.0204 | 0.071 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0248 | 0.2868 | 0.2868 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.0083 | 0.4087 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.003 | 0.0204 | 0.071 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.01 | 0.1057 | 0.4799 |
Toxoplasma gondii | ABC1 family protein | 0.003 | 0.0204 | 0.071 |
Brugia malayi | beta-lactamase family protein | 0.003 | 0.0204 | 0.045 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.