Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0464 | 0.0474 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.0342 | 0.1041 | 0.2905 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0464 | 0.0474 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.2525 | 1 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.2525 | 1 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.2525 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.0163 | 0.0456 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0202 | 0.0464 | 0.0464 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0962 | 0.3584 | 1 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0342 | 0.1041 | 0.1041 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0437 | 0.1429 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0738 | 0.2667 | 0.2667 |
Echinococcus granulosus | acetylcholinesterase | 0.0202 | 0.0464 | 0.0464 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.0342 | 0.1041 | 0.2905 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0202 | 0.0464 | 0.0474 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.1563 | 0.6053 | 1 |
Echinococcus multilocularis | sodium calcium exchanger | 0.2475 | 0.9795 | 0.9795 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0437 | 0.1429 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0202 | 0.0464 | 0.0464 |
Chlamydia trachomatis | biotin carboxylase | 0.0873 | 0.3221 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.099 | 0.3701 | 0.3778 |
Schistosoma mansoni | pyruvate carboxylase | 0.0962 | 0.3584 | 0.3584 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0962 | 0.3584 | 0.5922 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0962 | 0.3584 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.2436 | 0.9637 | 0.9838 |
Trypanosoma brucei | unspecified product | 0.0632 | 0.2232 | 0.2232 |
Echinococcus multilocularis | acetylcholinesterase | 0.0202 | 0.0464 | 0.0464 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0217 | 0.0529 | 0.0529 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0342 | 0.1041 | 0.172 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.0111 | 0.0309 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.0342 | 0.1041 | 0.2905 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0962 | 0.3584 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.0111 | 0.0309 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0342 | 0.1041 | 0.1041 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.0163 | 0.0456 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0115 | 0.0111 | 0.0309 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0962 | 0.3584 | 0.3584 |
Toxoplasma gondii | pyruvate carboxylase | 0.0962 | 0.3584 | 0.3584 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0738 | 0.2667 | 0.2667 |
Brugia malayi | Carboxylesterase family protein | 0.0202 | 0.0464 | 0.0482 |
Schistosoma mansoni | sodium/calcium exchanger | 0.2475 | 0.9795 | 0.9795 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0342 | 0.1041 | 0.172 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0962 | 0.3584 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0202 | 0.0464 | 0.0464 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0962 | 0.3584 | 0.5922 |
Loa Loa (eye worm) | carboxylesterase | 0.0202 | 0.0464 | 0.0474 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0962 | 0.3584 | 0.3584 |
Treponema pallidum | pyruvate carboxylase subunit B | 0.0088 | 0 | 0.5 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.0342 | 0.1041 | 0.1041 |
Mycobacterium ulcerans | carbamoyl phosphate synthase large subunit | 0.0217 | 0.0529 | 0.1476 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.2525 | 1 | 1 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0962 | 0.3584 | 0.3584 |
Trypanosoma brucei | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative | 0.0217 | 0.0529 | 0.0529 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0217 | 0.0529 | 0.0529 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0962 | 0.3584 | 1 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0962 | 0.3584 | 0.3584 |
Toxoplasma gondii | carbamoylphosphate synthetase | 0.0217 | 0.0529 | 0.0529 |
Wolbachia endosymbiont of Brugia malayi | carbamoyl phosphate synthase large subunit | 0.0217 | 0.0529 | 0.1476 |
Loa Loa (eye worm) | solute carrier family 8 | 0.2475 | 0.9795 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.2525 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0962 | 0.3584 | 0.3584 |
Mycobacterium leprae | ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 | 0.0342 | 0.1041 | 0.2905 |
Trypanosoma cruzi | glutamine-dependent carbamoyl-phosphate synthetase, putative | 0.0217 | 0.0529 | 0.0874 |
Leishmania major | carbamoyl-phosphate synthase, putative | 0.0217 | 0.0529 | 0.0529 |
Trypanosoma cruzi | glutamine dependent carbamoyl-phosphate synthase, putative | 0.0217 | 0.0529 | 0.0874 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0342 | 0.1041 | 0.1041 |
Plasmodium falciparum | carbamoyl phosphate synthetase | 0.0217 | 0.0529 | 0.0742 |
Brugia malayi | Sodium/calcium exchanger protein | 0.099 | 0.3701 | 0.384 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0431 | 0.1404 | 0.5 |
Echinococcus granulosus | sodium calcium exchanger | 0.2475 | 0.9795 | 0.9795 |
Mycobacterium leprae | Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) | 0.0342 | 0.1041 | 0.2905 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.0342 | 0.1041 | 0.2905 |
Mycobacterium leprae | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) | 0.0342 | 0.1041 | 0.2905 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.0342 | 0.1041 | 0.2905 |
Mycobacterium tuberculosis | Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 | 0.0342 | 0.1041 | 0.2905 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.0111 | 0.0309 |
Leishmania major | carboxylase, putative | 0.0962 | 0.3584 | 0.3584 |
Mycobacterium tuberculosis | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) | 0.0342 | 0.1041 | 0.2905 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.2436 | 0.9637 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.0163 | 0.0456 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0962 | 0.3584 | 0.3584 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.0111 | 0.0309 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0431 | 0.1404 | 0.5 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0342 | 0.1041 | 0.172 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.0342 | 0.1041 | 0.1041 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.0111 | 0.0309 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.0342 | 0.1041 | 0.2905 |
Echinococcus granulosus | acetylcholinesterase | 0.0202 | 0.0464 | 0.0464 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.1827 | 0.7136 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0962 | 0.3584 | 0.3584 |
Brugia malayi | Carboxylesterase family protein | 0.0202 | 0.0464 | 0.0482 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0342 | 0.1041 | 0.1041 |
Schistosoma mansoni | aspartate carbamoyltransferase | 0.0217 | 0.0529 | 0.0529 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.0111 | 0.0309 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0962 | 0.3584 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0738 | 0.2667 | 0.2667 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.0342 | 0.1041 | 0.1041 |
Echinococcus multilocularis | acetylcholinesterase | 0.0202 | 0.0464 | 0.0464 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.2525 | 1 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.1827 | 0.7136 | 1 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0962 | 0.3584 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.0163 | 0.0456 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.0342 | 0.1041 | 0.2905 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0962 | 0.3584 | 1 |
Plasmodium vivax | carbamoyl phosphate synthetase, putative | 0.0217 | 0.0529 | 0.0742 |
Chlamydia trachomatis | acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | 0.0342 | 0.1041 | 0.3233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.