Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0204 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0204 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0204 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0204 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0204 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0204 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0204 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0204 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0204 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0204 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 25 mm | Antifungal activity against Candida albicans NRRL Y-477 at 100 ug/ml after 24 hrs by agar well diffusion assay | ChEMBL. | 22480494 |
IZ (functional) | = 28 mm | Antifungal activity against Saccharomyces cerevisiae at 100 ug/ml after 24 hrs by agar well diffusion assay | ChEMBL. | 22480494 |
IZ (functional) | = 29 mm | Antimicrobial activity against Escherichia coli ATCC 25922 at 100 ug/ml after 24 hrs by agar well diffusion assay | ChEMBL. | 22480494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.