Detailed information for compound 1643889

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 307.373 | Formula: C16H13N5S
  • H donors: 2 H acceptors: 3 LogP: 3.29 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1nnc([nH]1)c1cccc2c1nc(NC1CC1)c1c2scc1
  • InChi: 1S/C16H13N5S/c1-2-10-13(11(3-1)15-17-8-18-21-15)20-16(19-9-4-5-9)12-6-7-22-14(10)12/h1-3,6-9H,4-5H2,(H,19,20)(H,17,18,21)
  • InChiKey: QSTDMPARCWMFIJ-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens casein kinase 2, alpha 1 polypeptide References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens casein kinase 2, beta polypeptide References
Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Brugia malayi Casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium parvum putative protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03097 casein kinase 2, alpha polypeptide, putative Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium falciparum casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126901 All targets in OG5_126901
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii CMGC kinase, CK2 family Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Cryptosporidium hominis protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase 2, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans likely protein kinase similar to S. cerevisiae CKA1 (YIL035C) alpha subunit of protein kinase 2, aka casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Brugia malayi Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium parvum putative casein kinase II regulatory subunit; besthit Pf 23508244 Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) CMGC/CK2 protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Echinococcus granulosus casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax unspecified product Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma congolense Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Neospora caninum casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase 2, alpha subunit Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Giardia lamblia Kinase, CMGC CK2 Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania major protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania major casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei gambiense protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni casein kinase II beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium parvum casein kinase II, alpha subunit, putative Get druggable targets OG5_126901 All targets in OG5_126901
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania infantum protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Theileria parva casein kinase II, alpha chain Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Neospora caninum YOR039Wp-like protein, related Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii casein kinase ii regulatory subunit protein Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Neospora caninum hypothetical protein Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei gambiense casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Babesia bovis casein kinase II beta 4 subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii ck2 beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Cryptosporidium hominis protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Leishmania donovani casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei Casein kinase II Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Trypanosoma brucei Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis casein kinase II, alpha chain (CK II) Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium yoelii casein kinase ii beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126901 All targets in OG5_126901
Plasmodium yoelii Protein kinase domain Get druggable targets OG5_126901 All targets in OG5_126901
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II alpha' subunit Get druggable targets OG5_126901 All targets in OG5_126901
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania infantum casein kinase II, putative Get druggable targets OG5_126901 All targets in OG5_126901
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis casein kinase ii subunit alpha Get druggable targets OG5_126901 All targets in OG5_126901

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi casein kinase II, alpha chain, putative casein kinase 2, alpha 1 polypeptide 391 aa 316 aa 51.3 %
Trypanosoma brucei protein lipid droplet kinase (LDK) Pim-2 proto-oncogene, serine/threonine kinase 311 aa 278 aa 28.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.1359 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0105 0.2258 0.2941
Mycobacterium ulcerans polyketide synthase 0.0159 0.4383 0.5834
Toxoplasma gondii CMGC kinase, CK2 family 0.0082 0.1359 0.0225
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.009 0.1676 0.224
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0169 0.4773 0.6376
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0132 0.3337 0.4398
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.1359 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0169 0.4773 0.6357
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0238 0.7486 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0114 0.2616 0.3495
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0055 0.0267 0.0356
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0148 0.3971 0.5305
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0082 0.1359 0.0476
Trypanosoma brucei Casein kinase II 0.0082 0.1359 0.5
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0159 0.4383 0.4383
Mycobacterium ulcerans Type I modular polyketide synthase 0.0159 0.4383 0.5834
Giardia lamblia Kinase, CMGC CK2 0.0082 0.1359 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0064 0.0647 0.0864
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0159 0.4383 0.5834
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0103 0.218 0.2574
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0082 0.1359 0.5
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0169 0.4773 0.6337
Mycobacterium ulcerans polyketide synthase Pks13 0.0238 0.7486 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.5751 0.6214
Mycobacterium leprae Polyketide synthase Pks13 0.0238 0.7486 1
Plasmodium vivax unspecified product 0.0082 0.1359 0.5
Plasmodium falciparum casein kinase 2, alpha subunit 0.0082 0.1359 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.5751 1
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.1359 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0159 0.4383 0.581
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0049 0.0039 0.0052
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0128 0.3157 0.4188
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0105 0.2258 0.2981
Entamoeba histolytica casein kinase, putative 0.0082 0.1359 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0169 0.4773 0.6337
Mycobacterium ulcerans Type I modular polyketide synthase 0.0159 0.4383 0.5834
Mycobacterium leprae Probable polyketide synthase Pks1 0.0169 0.4773 0.6337
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0238 0.7486 1
Entamoeba histolytica protein kinase domain containing protein 0.0082 0.1359 0.5
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0194 0.5751 0.3268
Mycobacterium ulcerans thioesterase 0.0132 0.3337 0.443
Mycobacterium ulcerans polyketide synthase 0.0169 0.4773 0.6357
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0169 0.4773 0.6357
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0154 0.4191 0.5599
Leishmania major casein kinase II, putative 0.0082 0.1359 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.1625 0.0823
Mycobacterium ulcerans polyketide synthase Pks9 0.0105 0.2258 0.2981
Trypanosoma cruzi casein kinase II, putative 0.0082 0.1359 0.5
Brugia malayi Casein kinase II, alpha chain 0.0082 0.1359 0.1359
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0148 0.3971 0.3889
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0159 0.4383 0.5856
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0159 0.4383 0.5856
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0169 0.4773 0.6376
Mycobacterium ulcerans fatty acid synthase Fas 0.005 0.0081 0.0056
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.013 0.324 0.4329
Mycobacterium ulcerans thioesterase TesA 0.0132 0.3337 0.443
Schistosoma mansoni protein kinase 0.0082 0.1359 0.2364
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.1359 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0154 0.4191 0.5599
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0039 0.0039
Toxoplasma gondii type I fatty acid synthase, putative 0.0169 0.4773 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0113 0.2576 0.3708
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0194 0.5751 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0194 0.5751 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0159 0.4383 0.581
Brugia malayi Protein kinase domain containing protein 0.0194 0.5751 0.5751
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0159 0.4383 0.5856
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0128 0.3157 0.4188
Brugia malayi AMP-binding enzyme family protein 0.0148 0.3971 0.3971
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.005 0.0081 0.0108
Onchocerca volvulus Fatty acid synthase homolog 0.0286 0.9418 1
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.1359 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.5751 0.6214
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0194 0.5751 0.5751
Loa Loa (eye worm) hypothetical protein 0.0267 0.8648 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0159 0.4383 0.5834
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.1359 1
Loa Loa (eye worm) fatty acid synthase 0.0157 0.43 0.4318
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0169 0.4773 0.6376
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0128 0.3157 0.4155
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.1359 1
Onchocerca volvulus 0.0277 0.9028 0.9285
Mycobacterium tuberculosis Probable thioesterase TesA 0.0132 0.3337 0.4459

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.015 uM Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate and 30 uM ATP by radiometric assay ChEMBL. 22460033
IC50 (binding) = 0.025 uM Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay ChEMBL. 22460033
IC50 (binding) = 0.062 uM Inhibition of human recombinant CK2 (alphaalpha-betabeta) holoenzyme using RRRDDDSDDD as substrate and 15 uM ATP by radiometric assay ChEMBL. 22460033

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.