Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, putative | 0.0915 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0915 | 1 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0474 | 0.2526 | 0.2526 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0915 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0915 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0915 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0915 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Onchocerca volvulus | 0.0915 | 1 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0614 | 0.4904 | 0.4904 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0915 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0614 | 0.4904 | 0.4904 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0915 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0614 | 0.4904 | 0.4904 |
Trypanosoma cruzi | cysteine protease, putative | 0.0474 | 0.2526 | 0.2526 |
Echinococcus granulosus | cathepsin L | 0.0474 | 0.2526 | 0.2526 |
Brugia malayi | Cathepsin L-like precursor | 0.0915 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0474 | 0.2526 | 0.2526 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0614 | 0.4904 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0614 | 0.4904 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0614 | 0.4904 | 0.4904 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0474 | 0.2526 | 0.2526 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0915 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0474 | 0.2526 | 0.2526 |
Onchocerca volvulus | Cathepsin L homolog | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0474 | 0.2526 | 0.2526 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0915 | 1 | 0.5 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0474 | 0.2526 | 0.2526 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0474 | 0.2526 | 0.2526 |
Brugia malayi | Cathepsin L-like precursor | 0.0915 | 1 | 1 |
Onchocerca volvulus | 0.0915 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0915 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0915 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0614 | 0.4904 | 0.4904 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0614 | 0.4904 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0915 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0915 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0915 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0915 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0915 | 1 | 0.5 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0474 | 0.2526 | 0.2526 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0915 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0915 | 1 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0915 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0915 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0915 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0614 | 0.4904 | 0.4904 |
Toxoplasma gondii | cathepsin CPL | 0.0915 | 1 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0915 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0915 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0474 | 0.2526 | 0.2526 |
Leishmania major | cathepsin L-like protease | 0.0915 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0915 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0915 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0915 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Onchocerca volvulus | 0.0915 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Onchocerca volvulus | 0.0915 | 1 | 1 | |
Loa Loa (eye worm) | fibroinase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0915 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0915 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0915 | 1 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0915 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0474 | 0.2526 | 0.2526 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0474 | 0.2526 | 0.2526 |
Echinococcus multilocularis | cysteine protease | 0.0915 | 1 | 1 |
Onchocerca volvulus | 0.0915 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0915 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0614 | 0.4904 | 0.4904 |
Onchocerca volvulus | 0.0915 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0614 | 0.4904 | 0.4904 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0915 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0915 | 1 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0915 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0915 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0915 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0474 | 0.2526 | 0.2526 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0614 | 0.4904 | 0.4904 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0915 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0915 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0915 | 1 | 0.5 |
Onchocerca volvulus | 0.0915 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0614 | 0.4904 | 0.4904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.323 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.095 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.