Detailed information for compound 1644210

Basic information

Technical information
  • TDR Targets ID: 1644210
  • Name: N-[1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl] -2-oxopyrimidin-4-yl]benzamide
  • MW: 331.323 | Formula: C16H17N3O5
  • H donors: 3 H acceptors: 4 LogP: 0.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(CC1O)n1ccc(nc1=O)NC(=O)c1ccccc1
  • InChi: 1S/C16H17N3O5/c20-9-12-11(21)8-14(24-12)19-7-6-13(18-16(19)23)17-15(22)10-4-2-1-3-5-10/h1-7,11-12,14,20-21H,8-9H2,(H,17,18,22,23)
  • InChiKey: MPSJHJFNKMUKCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]benzamide
  • N-[1-[4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-2-oxo-4-pyrimidinyl]benzamide
  • N-[1-(4-hydroxy-5-methylol-tetrahydrofuran-2-yl)-2-keto-pyrimidin-4-yl]benzamide
  • N-[1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-pyrimidin-4-yl]benzamide
  • NCI60_004753
  • NSC609074

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0232 0.005
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0226 0.2367 0.2367
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0058 0.0527 0.0527
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0226 0.2367 0.2367
Leishmania major cathepsin L-like protease 0.0923 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0058 0.0527 0.0527
Plasmodium falciparum cysteine proteinase falcipain 1 0.0478 0.5121 0.4054
Onchocerca volvulus 0.0923 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0278 0.2931 0.2929
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0304 0.3214 0.3213
Loa Loa (eye worm) melatonin receptor type 1A 0.0226 0.2367 0.2366
Onchocerca volvulus 0.0226 0.2367 0.2226
Schistosoma mansoni biogenic amine receptor 0.0226 0.2367 0.2226
Loa Loa (eye worm) hypothetical protein 0.0174 0.1794 0.1793
Loa Loa (eye worm) ctsf protein 0.0923 1 1
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Loa Loa (eye worm) hypothetical protein 0.032 0.3397 0.3396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0219 0.229 0.0604
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0226 0.2367 0.2226
Entamoeba histolytica cysteine proteinase, putative 0.0619 0.6673 0.6594
Echinococcus granulosus cathepsin L 0.0478 0.5121 0.512
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.023
Loa Loa (eye worm) hypothetical protein 0.0174 0.1794 0.1793
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0027 0.0182 0.0181
Echinococcus granulosus glycine receptor subunit alpha 1 0.0058 0.0527 0.0526
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0226 0.2367 0.2366
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.1794 0.1641
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0058 0.0527 0.0526
Giardia lamblia Cathepsin B precursor 0.0219 0.229 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 1 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0058 0.0527 0.0527
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0058 0.0527 0.0526
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.5121 0.5005
Echinococcus granulosus cathepsin b 0.032 0.3397 0.3396
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Toxoplasma gondii cathepsin B 0.0219 0.229 0.1809
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Schistosoma mansoni cpg binding protein 0.0034 0.0257 0.0076
Brugia malayi hypothetical protein 0.0027 0.0182 0.0182
Trypanosoma cruzi cysteine proteinase, putative 0.0478 0.5121 0.4054
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0027 0.0182 0.0181
Onchocerca volvulus 0.0226 0.2367 0.2226
Entamoeba histolytica hypothetical protein 0.0042 0.035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0141 0.1435 0.1434
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0226 0.2367 0.2226
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine protease, putative 0.0174 0.1794 0.1599
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0027 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus granulosus biogenic amine 5HT receptor 0.0226 0.2367 0.2366
Brugia malayi G-protein coupled receptor 0.0226 0.2367 0.2367
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0058 0.0527 0.0526
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Brugia malayi Cation transporter family protein 0.0141 0.1435 0.1435
Echinococcus granulosus biogenic amine 5HT receptor 0.0226 0.2367 0.2366
Schistosoma mansoni cathepsin F (C01 family) 0.0923 1 1
Brugia malayi AKH receptor 0.0226 0.2367 0.2367
Brugia malayi cathepsin F-like cysteine proteinase 0.0174 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus granulosus neuropeptide receptor A26 0.0226 0.2367 0.2366
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus multilocularis neuropeptide receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Onchocerca volvulus 0.0226 0.2367 0.2226
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0226 0.2367 0.2366
Schistosoma mansoni neuropeptide receptor 0.0226 0.2367 0.2226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Schistosoma mansoni hypothetical protein 0.0226 0.2367 0.2226
Brugia malayi cathepsin B-like cysteine proteinase 0.032 0.3397 0.3397
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0174 0.1794 0.1641
Echinococcus granulosus nAChR subunit 0.0031 0.0232 0.023
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0226 0.2367 0.2366
Schistosoma mansoni nAChR subunit 0.0058 0.0527 0.0351
Schistosoma mansoni cathepsin s 0.0304 0.3214 0.3088
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0226 0.2367 0.2366
Echinococcus granulosus dro:myosuppressin receptor 0.0226 0.2367 0.2366
Brugia malayi cathepsin L-like precursor 0.0619 0.6673 0.6673
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) ACC-1 protein 0.0058 0.0527 0.0526
Trypanosoma cruzi cysteine peptidase, putative 0.0304 0.3214 0.1731
Echinococcus multilocularis dro:myosuppressin receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.023
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0226 0.2367 0.2226
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.5121 0.5005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0226 0.2367 0.2226
Echinococcus multilocularis rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Schistosoma mansoni hypothetical protein 0.0226 0.2367 0.2226
Onchocerca volvulus 0.0031 0.0232 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Brugia malayi putative neuropeptide receptor 0.0226 0.2367 0.2367
Onchocerca volvulus 0.0923 1 1
Loa Loa (eye worm) fibroinase 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus multilocularis cathepsin b 0.032 0.3397 0.3396
Echinococcus granulosus glycine receptor subunit beta 0.0058 0.0527 0.0526
Onchocerca volvulus 0.0057 0.0508 0.0332
Onchocerca volvulus 0.0923 1 1
Echinococcus granulosus cathepsin l1 0.0619 0.6673 0.6673
Brugia malayi Cation transporter family protein 0.0058 0.0527 0.0527
Onchocerca volvulus Putative nachr subunit 0.0058 0.0527 0.0351
Echinococcus multilocularis rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Echinococcus granulosus neuropeptide FF receptor 2 0.0226 0.2367 0.2366
Schistosoma mansoni amine GPCR 0.0226 0.2367 0.2226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0058 0.0527 0.0526
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.5121 0.5005
Schistosoma mansoni neuropeptide receptor 0.0226 0.2367 0.2226
Entamoeba histolytica cysteine proteinase 1, putative 0.0478 0.5121 0.5005
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Plasmodium vivax unspecified product 0.0478 0.5121 0.4054
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0058 0.0527 0.0527
Echinococcus granulosus g protein coupled receptor 0.0226 0.2367 0.2366
Echinococcus granulosus rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0058 0.0527 0.0526
Schistosoma mansoni cathepsin F (C01 family) 0.0619 0.6673 0.6611
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0174 0.1794 0.1793
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Brugia malayi G-protein coupled receptor 0.0226 0.2367 0.2367
Leishmania major cysteine peptidase A (CPA) 0.0923 1 1
Brugia malayi hypothetical protein 0.0027 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Schistosoma mansoni opsin-like receptor 0.0226 0.2367 0.2226
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0923 1 1
Brugia malayi RE15519p 0.0226 0.2367 0.2367
Echinococcus granulosus neuropeptides capa receptor 0.0226 0.2367 0.2366
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0226 0.2367 0.2367
Brugia malayi Cathepsin L-like precursor 0.0923 1 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0058 0.0527 0.0351
Onchocerca volvulus 0.0174 0.1794 0.1641
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0226 0.2367 0.2366
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Onchocerca volvulus 0.0923 1 1
Onchocerca volvulus 0.0619 0.6673 0.6611
Schistosoma mansoni hypothetical protein 0.048 0.5151 0.5061
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0226 0.2367 0.2366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0619 0.6673 0.5946
Onchocerca volvulus Cathepsin L homolog 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus granulosus glycine receptor subunit alpha 1 0.0058 0.0527 0.0526
Echinococcus granulosus neuropeptide s receptor 0.0226 0.2367 0.2366
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0058 0.0527 0.0526
Loa Loa (eye worm) hypothetical protein 0.0619 0.6673 0.6673
Onchocerca volvulus 0.0058 0.0527 0.0351
Brugia malayi Cathepsin L-like precursor 0.0923 1 1
Brugia malayi Cathepsin L-like precursor 0.0619 0.6673 0.6673
Echinococcus multilocularis neuropeptide FF receptor 2 0.0226 0.2367 0.2366
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0226 0.2367 0.2226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Plasmodium falciparum cysteine proteinase falcipain 3 0.0923 1 1
Leishmania major cathepsin L-like protease 0.0923 1 1
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Brugia malayi Dopamine receptor protein 1 0.0226 0.2367 0.2367
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0226 0.2367 0.2366
Echinococcus multilocularis cpg binding protein 0.0036 0.0278 0.0276
Echinococcus granulosus cathepsin L cysteine protease 0.0478 0.5121 0.512
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.035 0.0171
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0027 0.0182 0.0182
Schistosoma mansoni neurotransmitter gated ion channel 0.0031 0.0232 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0226 0.2367 0.2226
Onchocerca volvulus 0.0058 0.0527 0.0351
Echinococcus multilocularis glycine receptor subunit beta 0.0058 0.0527 0.0526
Schistosoma mansoni cathepsin S (C01 family) 0.0174 0.1794 0.1641
Brugia malayi follicle stimulating hormone receptor 0.0496 0.5328 0.5328
Onchocerca volvulus Cathepsin F homolog 0.0923 1 1
Echinococcus granulosus cysteine protease 0.0478 0.5121 0.512
Plasmodium vivax vivapain-2 0.0923 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0226 0.2367 0.2226
Schistosoma mansoni histamine h1 receptor 0.0226 0.2367 0.2226
Loa Loa (eye worm) LGC-31 protein 0.0058 0.0527 0.0526
Brugia malayi hypothetical protein 0.0027 0.0182 0.0182
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Onchocerca volvulus 0.0141 0.1435 0.1276
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0923 1 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0058 0.0527 0.0526
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0226 0.2367 0.2226
Loa Loa (eye worm) G-protein coupled receptor 0.0226 0.2367 0.2366
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.3397 0.3275
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0226 0.2367 0.2226
Entamoeba histolytica cysteine proteinase 2 0.0478 0.5121 0.5005
Brugia malayi neuropeptide F receptor 0.0226 0.2367 0.2367
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.023
Echinococcus granulosus rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Schistosoma mansoni hypothetical protein 0.0226 0.2367 0.2226
Echinococcus multilocularis G protein coupled receptor 139 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0619 0.6673 0.6673
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.023
Echinococcus multilocularis cathepsin L 0.0174 0.1794 0.1793
Onchocerca volvulus 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus granulosus rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0027 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0058 0.0527 0.0351
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0226 0.2367 0.2366
Loa Loa (eye worm) G-protein coupled receptor 0.0226 0.2367 0.2366
Schistosoma mansoni nAChR subunit 0.0058 0.0527 0.0351
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0226 0.2367 0.2367
Onchocerca volvulus Cathepsin L homolog 0.0174 0.1794 0.1641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0226 0.2367 0.2366
Leishmania major cathepsin L-like protease 0.0923 1 1
Brugia malayi Cathepsin L-like precursor 0.0923 1 1
Echinococcus granulosus dnaJ subfamily B 0.048 0.5151 0.5151
Echinococcus multilocularis g protein coupled receptor 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0226 0.2367 0.2366
Echinococcus multilocularis somatostatin receptor 0.0226 0.2367 0.2366
Trypanosoma cruzi cruzipain precursor, putative 0.0923 1 1
Leishmania major cathepsin L-like protease 0.0923 1 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0058 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.023
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Brugia malayi Dopamine receptor 0.0226 0.2367 0.2367
Brugia malayi Cathepsin L-like precursor 0.0619 0.6673 0.6673
Brugia malayi Papain family cysteine protease containing protein 0.0478 0.5121 0.5121
Onchocerca volvulus Neuropeptide F receptor homolog 0.0226 0.2367 0.2226
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0226 0.2367 0.2226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0478 0.5121 0.4054
Echinococcus granulosus rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Echinococcus multilocularis G-protein coupled receptor, putative 0.0226 0.2367 0.2366
Echinococcus multilocularis neuropeptide s receptor 0.0226 0.2367 0.2366
Schistosoma mansoni biogenic amine (5HT) receptor 0.0226 0.2367 0.2226
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0174 0.1794 0.1599
Brugia malayi cathepsin F-like cysteine proteinase 0.0304 0.3214 0.3214
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0174 0.1794 0.1641
Echinococcus multilocularis orexin receptor type 2 0.0226 0.2367 0.2366
Echinococcus multilocularis g protein coupled receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0141 0.1435 0.1434
Entamoeba histolytica cysteine protease, putative 0.0174 0.1794 0.1599
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0031 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0671 0.0498
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0232 0.0232
Schistosoma mansoni amine GPCR 0.0226 0.2367 0.2226
Entamoeba histolytica cysteine proteinase, putative 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0027 0.0182 0.0181
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0174 0.1794 0.1793
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Echinococcus multilocularis nAChR subunit 0.0058 0.0527 0.0526
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0058 0.0527 0.0526
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0226 0.2367 0.2366
Toxoplasma gondii cathepsin CPC2 0.0174 0.1794 0.1282
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Onchocerca volvulus 0.0226 0.2367 0.2226
Trypanosoma cruzi cruzipain precursor, putative 0.0304 0.3214 0.1731
Schistosoma mansoni amine GPCR 0.0226 0.2367 0.2226
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Onchocerca volvulus 0.0226 0.2367 0.2226
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0478 0.5121 0.503
Echinococcus granulosus 7TM GPCR rhodopsin 0.0226 0.2367 0.2366
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0027 0.0182 0.0181
Echinococcus granulosus cathepsin L 0.0174 0.1794 0.1793
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.035 0.0349
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.023
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0058 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0278 0.2931 0.2929
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0923 1 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0058 0.0527 0.0526
Loa Loa (eye worm) hypothetical protein 0.0304 0.3214 0.3213
Echinococcus multilocularis cathepsin L cysteine protease 0.0923 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.032 0.3397 0.3275
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0058 0.0527 0.0527
Echinococcus granulosus cathepsin b 0.032 0.3397 0.3396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0478 0.5121 0.3672
Trypanosoma cruzi cysteine proteinase, putative 0.0478 0.5121 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.1794 0.1641
Schistosoma mansoni nAChR subunit 0.0058 0.0527 0.0351
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Brugia malayi GnHR receptor homolog 0.0226 0.2367 0.2367
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0226 0.2367 0.2367
Echinococcus multilocularis rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Brugia malayi Serotonin receptor 0.0226 0.2367 0.2367
Schistosoma mansoni hypothetical protein 0.0057 0.0508 0.0332
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0058 0.0527 0.0526
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0058 0.0527 0.0526
Loa Loa (eye worm) hypothetical protein 0.0174 0.1794 0.1793
Echinococcus granulosus tm gpcr rhodopsin 0.0226 0.2367 0.2366
Loa Loa (eye worm) cathepsin B 0.0219 0.229 0.2289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0478 0.5121 0.4054
Loa Loa (eye worm) hypothetical protein 0.0923 1 1
Schistosoma mansoni nAChR subunit 0.0058 0.0527 0.0351
Schistosoma mansoni hypothetical protein 0.0042 0.035 0.0171
Trypanosoma cruzi cysteine peptidase, putative 0.0478 0.5121 0.4054
Toxoplasma gondii cathepsin CPC1 0.0174 0.1794 0.1282
Brugia malayi cathepsin L precursor 0.0174 0.1794 0.1794
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0058 0.0527 0.0527
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0226 0.2367 0.2226
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0226 0.2367 0.2226
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0058 0.0527 0.0526
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Schistosoma mansoni nAChR subunit 0.0058 0.0527 0.0351
Loa Loa (eye worm) hypothetical protein 0.0174 0.1794 0.1793
Onchocerca volvulus 0.0226 0.2367 0.2226
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.1794 0.1641
Echinococcus granulosus glycine receptor subunit beta 0.0058 0.0527 0.0526
Onchocerca volvulus 0.0226 0.2367 0.2226
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0174 0.1794 0.1793
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.1794 0.1641
Trypanosoma cruzi cysteine protease, putative 0.0478 0.5121 0.4054
Toxoplasma gondii cathepsin CPL 0.0923 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0923 1 1
Entamoeba histolytica hypothetical protein 0.0042 0.035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Brugia malayi G protein-coupled receptor 0.0226 0.2367 0.2367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0058 0.0527 0.0527
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0304 0.3214 0.3214
Echinococcus multilocularis serotonin receptor 0.0226 0.2367 0.2366
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0923 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0226 0.2367 0.2226
Echinococcus multilocularis cathepsin b 0.032 0.3397 0.3396
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0226 0.2367 0.2366
Echinococcus multilocularis neuropeptides capa receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Schistosoma mansoni nAChR subunit 0.0058 0.0527 0.0351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0226 0.2367 0.2366
Loa Loa (eye worm) neuropeptide F receptor 0.0226 0.2367 0.2366
Brugia malayi Melatonin receptor type 1A 0.0226 0.2367 0.2367
Echinococcus granulosus nAChR subunit 0.0058 0.0527 0.0526
Echinococcus multilocularis rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Onchocerca volvulus 0.0226 0.2367 0.2226
Leishmania major cathepsin L-like protease 0.0923 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Echinococcus granulosus serotonin receptor 0.0226 0.2367 0.2366
Brugia malayi ORL1-like opioid receptor 0.0226 0.2367 0.2367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 1 1
Echinococcus granulosus orexin receptor type 2 0.0226 0.2367 0.2366
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0508 0.0508
Entamoeba histolytica hypothetical protein 0.0042 0.035 0.0121
Schistosoma mansoni cathepsin C 0.0174 0.1794 0.1641
Schistosoma mansoni amine GPCR 0.0226 0.2367 0.2226
Echinococcus multilocularis cathepsin L 0.0478 0.5121 0.512
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0304 0.3214 0.3213
Schistosoma mansoni survival motor neuron protein 0.0057 0.0508 0.0332
Loa Loa (eye worm) cysteine protease 0.0923 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0226 0.2367 0.2226
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0058 0.0527 0.0527
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0058 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.023
Onchocerca volvulus Cathepsin L homolog 0.0923 1 1
Loa Loa (eye worm) GABA receptor subunit 0.0031 0.0232 0.023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0923 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0226 0.2367 0.2366
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0226 0.2367 0.2226
Onchocerca volvulus 0.0226 0.2367 0.2226
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0174 0.1794 0.1793
Brugia malayi Papain family cysteine protease containing protein 0.0174 0.1794 0.1794
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Leishmania major cathepsin L-like protease 0.0923 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0923 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0226 0.2367 0.2226
Brugia malayi Papain family cysteine protease containing protein 0.0174 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Schistosoma mansoni neuropeptide F-like receptor 0.0226 0.2367 0.2226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0226 0.2367 0.2226
Echinococcus multilocularis nAChR subunit 0.0031 0.0232 0.023
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Onchocerca volvulus 0.0923 1 1
Echinococcus granulosus g protein coupled receptor 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0174 0.1794 0.1641
Loa Loa (eye worm) hypothetical protein 0.0304 0.3214 0.3213
Onchocerca volvulus 0.0923 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0174 0.1794 0.1641
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0058 0.0527 0.0351
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Giardia lamblia Cathepsin B precursor 0.0219 0.229 1
Brugia malayi Dopamine receptor protein 2 0.0226 0.2367 0.2367
Trypanosoma cruzi cysteine peptidase, putative 0.0923 1 1
Onchocerca volvulus 0.0226 0.2367 0.2226
Echinococcus granulosus tm gpcr rhodopsin 0.0226 0.2367 0.2366
Schistosoma mansoni opsin-like receptor 0.0226 0.2367 0.2226
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0058 0.0527 0.0526
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0058 0.0527 0.0526
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Onchocerca volvulus 0.0226 0.2367 0.2226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0226 0.2367 0.2226
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus multilocularis survival motor neuron protein 1 0.0278 0.2931 0.2929
Trypanosoma cruzi cysteine peptidase, putative 0.0923 1 1
Echinococcus granulosus hypothetical protein 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Leishmania major cathepsin L-like protease 0.0923 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0226 0.2367 0.2226
Echinococcus granulosus rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Onchocerca volvulus 0.0226 0.2367 0.2226
Entamoeba histolytica cysteine proteinase, putative 0.0923 1 1
Echinococcus granulosus cpg binding protein 0.0036 0.0278 0.0276
Echinococcus multilocularis cysteine protease 0.0923 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0182 0.0182
Echinococcus multilocularis neuropeptide Y receptor 0.0226 0.2367 0.2366
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0174 0.1794 0.1641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0619 0.6673 0.5946
Brugia malayi Cathepsin L-like precursor 0.0923 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Onchocerca volvulus 0.0226 0.2367 0.2226
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0226 0.2367 0.2226
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.3397 0.3275
Loa Loa (eye worm) hypothetical protein 0.0619 0.6673 0.6673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Echinococcus granulosus g protein coupled receptor 0.0226 0.2367 0.2366
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0058 0.0527 0.0526
Echinococcus multilocularis rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus granulosus cathepsin l1 0.0923 1 1
Echinococcus granulosus g-protein coupled receptor 0.0226 0.2367 0.2366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Schistosoma mansoni amine GPCR 0.0226 0.2367 0.2226
Brugia malayi hypothetical protein 0.0027 0.0182 0.0182
Echinococcus multilocularis allatostatin A receptor 0.0226 0.2367 0.2366
Echinococcus granulosus neuropeptide receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0174 0.1794 0.1793
Loa Loa (eye worm) neuropeptide F receptor 0.0226 0.2367 0.2366
Schistosoma mansoni adenoreceptor 0.0226 0.2367 0.2226
Brugia malayi Tachykinin-like peptides receptor 99D 0.0226 0.2367 0.2367
Trypanosoma cruzi cysteine peptidase, putative 0.0923 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0226 0.2367 0.2226
Entamoeba histolytica cysteine protease, putative 0.0923 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0058 0.0527 0.0527
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0141 0.1435 0.1276
Brugia malayi Cation transporter family protein 0.0058 0.0527 0.0527
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.3397 0.3275
Schistosoma mansoni neuropeptide receptor 0.0226 0.2367 0.2226
Onchocerca volvulus 0.0226 0.2367 0.2226
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.035 0.0349
Onchocerca volvulus 0.0226 0.2367 0.2226
Echinococcus multilocularis sex peptide receptor 0.0226 0.2367 0.2366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0478 0.5121 0.3672
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0182 0.0182
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0226 0.2367 0.2226
Echinococcus granulosus cathepsin l cysteine peptidase 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Giardia lamblia Cathepsin B precursor 0.0219 0.229 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0226 0.2367 0.2226
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0031 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0619 0.6673 0.6673
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0027 0.0182 0.0181
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0619 0.6673 0.5946
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Entamoeba histolytica hypothetical protein 0.0042 0.035 0.0121
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.5121 0.5005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0058 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Plasmodium vivax vivapain-1 0.0478 0.5121 0.4054
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0027 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0219 0.229 0.2147
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Brugia malayi putative neuropeptide receptor NPR1 0.0226 0.2367 0.2367
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Echinococcus multilocularis cathepsin L cysteine protease 0.0923 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0923 1 1
Echinococcus multilocularis dnaJ subfamily B 0.048 0.5151 0.5151
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0226 0.2367 0.2366
Echinococcus granulosus sex peptide receptor 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine protease, putative 0.0174 0.1794 0.1599
Plasmodium vivax vivapain-3 0.0478 0.5121 0.4054
Onchocerca volvulus 0.0034 0.0257 0.0076
Echinococcus multilocularis neuropeptides capa receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0114 0.114 0.1139
Onchocerca volvulus 0.0226 0.2367 0.2226
Brugia malayi hypothetical protein 0.0042 0.035 0.035
Echinococcus multilocularis neuropeptide receptor 0.0226 0.2367 0.2366
Brugia malayi Papain family cysteine protease containing protein 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Brugia malayi cathepsin L-like cysteine proteinase 0.0174 0.1794 0.1794
Echinococcus granulosus rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0058 0.0527 0.0527
Echinococcus multilocularis rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Brugia malayi CXXC zinc finger family protein 0.0034 0.0257 0.0257
Brugia malayi Serotonin receptor 0.0226 0.2367 0.2367
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0923 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Brugia malayi Cathepsin L-like precursor 0.0923 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0923 1 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0058 0.0527 0.0526
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0058 0.0527 0.0526
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0226 0.2367 0.2226
Schistosoma mansoni biogenic amine receptor 0.0226 0.2367 0.2226
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Plasmodium vivax unspecified product 0.0304 0.3214 0.1731
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0226 0.2367 0.2226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0058 0.0527 0.0526
Loa Loa (eye worm) acetylcholine receptor protein 0.0027 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Onchocerca volvulus 0.0058 0.0527 0.0351
Schistosoma mansoni neuropeptide receptor 0.0226 0.2367 0.2226
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0031 0.0232 0.005
Echinococcus granulosus allatostatin A receptor 0.0226 0.2367 0.2366
Brugia malayi neuropeptide F receptor 0.0226 0.2367 0.2367
Schistosoma mansoni myosin xvIII 0.0226 0.2367 0.2226
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0058 0.0527 0.0351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 1 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0058 0.0527 0.0526
Schistosoma mansoni opsin-like receptor 0.0226 0.2367 0.2226
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0058 0.0527 0.0527
Brugia malayi Papain family cysteine protease containing protein 0.0478 0.5121 0.5121
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0058 0.0527 0.0526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Schistosoma mansoni nAChR subunit 0.0058 0.0527 0.0351
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0182 0.0182
Schistosoma mansoni biogenic amine receptor 0.0226 0.2367 0.2226
Brugia malayi fibroinase precursor 0.0174 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Entamoeba histolytica cysteine protease, putative 0.0174 0.1794 0.1599
Brugia malayi G protein-coupled receptor F59B2.13 0.0226 0.2367 0.2367
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Schistosoma mansoni hypothetical protein 0.0226 0.2367 0.2226
Brugia malayi Papain family cysteine protease containing protein 0.0174 0.1794 0.1794
Echinococcus granulosus somatostatin receptor 0.0226 0.2367 0.2366
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 1 1
Brugia malayi hypothetical protein 0.0027 0.0182 0.0182
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0058 0.0527 0.0526
Onchocerca volvulus 0.0031 0.0232 0.005
Plasmodium vivax vivapain-2 0.0923 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0174 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Echinococcus multilocularis fmrfamide receptor 0.0226 0.2367 0.2366
Schistosoma mansoni neuropeptide F-like receptor 0.0226 0.2367 0.2226
Echinococcus multilocularis serotonin receptor 0.0226 0.2367 0.2366
Entamoeba histolytica hypothetical protein 0.0174 0.1794 0.1599
Echinococcus multilocularis rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0174 0.1794 0.1599
Echinococcus multilocularis neuropeptide Y receptor 0.0226 0.2367 0.2366
Brugia malayi cathepsin Z-like cysteine proteinase 0.0174 0.1794 0.1794
Schistosoma mansoni cpg binding protein 0.0036 0.0278 0.0097
Loa Loa (eye worm) TYRA-2 protein 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine protease, putative 0.0174 0.1794 0.1599
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Echinococcus multilocularis fmrfamide receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) ACC-1 protein 0.0058 0.0527 0.0526
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0027 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0181
Brugia malayi sulfakinin receptor protein 0.0226 0.2367 0.2367
Onchocerca volvulus 0.0141 0.1435 0.1276
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0058 0.0527 0.0526
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0478 0.5121 0.503
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Echinococcus granulosus neuropeptide receptor 0.0226 0.2367 0.2366
Entamoeba histolytica cysteine protease, putative 0.0174 0.1794 0.1599
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0058 0.0527 0.0526
Loa Loa (eye worm) hypothetical protein 0.0031 0.0232 0.023
Onchocerca volvulus 0.0141 0.1435 0.1276
Echinococcus granulosus tm gpcr rhodopsin 0.0226 0.2367 0.2366
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0226 0.2367 0.2226
Echinococcus granulosus peptide allatostatin:somatostatin 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus multilocularis glycine receptor subunit beta 0.0058 0.0527 0.0526
Onchocerca volvulus 0.0226 0.2367 0.2226
Echinococcus multilocularis cysteine protease 0.0923 1 1
Brugia malayi hypothetical protein 0.0278 0.2931 0.2931
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0257 0.0255
Echinococcus granulosus alpha 1A adrenergic receptor 0.0226 0.2367 0.2366
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0219 0.229 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Schistosoma mansoni neuropeptide f receptor 76f 0.0226 0.2367 0.2226
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0141 0.1435 0.1276
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0226 0.2367 0.2366
Brugia malayi cathepsin Z-like cysteine proteinase 0.0174 0.1794 0.1794
Echinococcus granulosus fmrfamide receptor 0.0226 0.2367 0.2366
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0226 0.2367 0.2366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.2367 0.2366
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0058 0.0527 0.0526
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0478 0.5121 0.503
Brugia malayi larval opioid receptor 0.0226 0.2367 0.2367
Echinococcus granulosus rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0058 0.0527 0.0526
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0478 0.5121 0.4054
Echinococcus granulosus neuropeptides capa receptor 0.0226 0.2367 0.2366
Toxoplasma gondii preprocathepsin c precursor, putative 0.0174 0.1794 0.1282
Echinococcus granulosus neuropeptide Y receptor 0.0226 0.2367 0.2366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0923 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0496 0.5328 0.5327
Echinococcus granulosus 7tm_1 domain containing protein 0.0226 0.2367 0.2366
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.1794 0.1641
Entamoeba histolytica cysteine protease, putative 0.0478 0.5121 0.5005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0226 0.2367 0.2366
Brugia malayi Cathepsin L-like precursor 0.0304 0.3214 0.3214
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.032 0.3397 0.1954
Schistosoma mansoni cpg binding protein 0.0036 0.0278 0.0097
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0058 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0058 0.0527 0.0526
Echinococcus multilocularis g protein coupled receptor 0.0226 0.2367 0.2366
Brugia malayi hypothetical protein 0.0226 0.2367 0.2367
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0058 0.0527 0.0527
Leishmania major cathepsin L-like protease 0.0923 1 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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