Detailed information for compound 1644889

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.561 | Formula: C25H33N5O4
  • H donors: 2 H acceptors: 3 LogP: 4.44 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Nc1ccc(cc1C)Nc1ncnc2c1cc(OC)c(c2)OCCN(CC)CC
  • InChi: 1S/C25H33N5O4/c1-6-30(7-2)11-12-34-23-15-21-19(14-22(23)32-5)24(27-16-26-21)28-18-9-10-20(17(4)13-18)29-25(31)33-8-3/h9-10,13-16H,6-8,11-12H2,1-5H3,(H,29,31)(H,26,27,28)
  • InChiKey: KZRULMBNWRZHON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0009 0.0004
Leishmania major acetyl-CoA carboxylase, putative 1.1413 0.9961 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.6176 0.5373 0.5591
Schistosoma mansoni tyrosine kinase 0.0098 0.0051 0.0046
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.04 0.0315 0.0241
Schistosoma mansoni microtubule-associated protein tau 0.385 0.3337 0.3334
Trichomonas vaginalis PIKK family atypical protein kinase 0.1101 0.0929 0.1299
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.4062 0.3523 0.3665
Echinococcus multilocularis 0.0355 0.0276 0.0272
Loa Loa (eye worm) phosphatidylinositol 3 0.1101 0.0929 0.0966
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.0276 0.0021
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0698 0.0576 0.0572
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0959 0.0805 0.107
Trypanosoma cruzi acetyl-CoA carboxylase 0.7066 0.6153 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.2184 0.1878 0.3356
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.1547 0.1319 0.1316
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.0085 0.0081
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1479 0.126 0.1197
Mycobacterium ulcerans hypothetical protein 0.04 0.0315 0.074
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0085 0.0081
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.04 0.0315 0.0241
Echinococcus multilocularis musashi 0.0075 0.003 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.2225 0.1913 0.3226
Entamoeba histolytica hypothetical protein 0.0698 0.0576 0.0883
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0983 0.0826 0.2108
Loa Loa (eye worm) hypothetical protein 0.0097 0.005 0.0052
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.0126 0.0131
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.04 0.0315 0.0241
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.495 0.43 0.7961
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0355 0.0276 0.0274
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0983 0.0826 0.0822
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.4347 0.3772 0.3739
Trichomonas vaginalis PIKK family atypical protein kinase 0.1664 0.1422 0.2264
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.04 0.0315 0.0313
Echinococcus multilocularis tumor protein p63 0.034 0.0263 0.0259
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0698 0.0576 0.0572
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0698 0.0576 0.0883
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.4062 0.3523 0.352
Onchocerca volvulus Tyrosine kinase homolog 0.0172 0.0115 0.3989
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0039 0.0036
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1101 0.0929 0.1502
Trichomonas vaginalis PIKK family atypical protein kinase 0.2367 0.2038 0.347
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.04 0.0315 0.0311
Entamoeba histolytica hypothetical protein 0.0355 0.0276 0.0312
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0959 0.0805 0.1056
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 1.1413 0.9961 0.9961
Trichomonas vaginalis PIKK family atypical protein kinase 0.293 0.2531 0.4435
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.293 0.2531 0.4108
Echinococcus granulosus epidermal growth factor receptor 0.0098 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0698 0.0576 0.06
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0075 0.003 0.0032
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.04 0.0315 0.0313
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2184 0.1878 0.1954
Giardia lamblia GTOR 0.293 0.2531 0.9477
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0128 0.0077 0.0116
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.4347 0.3772 0.377
Trichomonas vaginalis PIKK family atypical protein kinase 0.2367 0.2038 0.347
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.04 0.0315 0.0328
Schistosoma mansoni acetyl-CoA carboxylase 1.1413 0.9961 0.9961
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0698 0.0576 0.0572
Schistosoma mansoni hypothetical protein 0.0127 0.0076 0.0072
Onchocerca volvulus 0.0355 0.0276 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.2225 0.1913 0.1918
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.04 0.0315 0.0311
Loa Loa (eye worm) hypothetical protein 0.0073 0.0029 0.003
Brugia malayi intermediate filament protein 0.0075 0.003 0.0032
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.04 0.0315 0.0311
Echinococcus granulosus intermediate filament protein 0.0075 0.003 0.0026
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.4062 0.3523 0.352
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0355 0.0276 0.0272
Brugia malayi hypothetical protein 0.0168 0.0112 0.0116
Schistosoma mansoni hypothetical protein 0.0355 0.0276 0.0272
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.4347 0.3772 0.3739
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.1547 0.1319 0.2137
Schistosoma mansoni hypothetical protein 0.0097 0.005 0.0046
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.04 0.0315 0.0313
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.1547 0.1319 0.3475
Loa Loa (eye worm) hypothetical protein 0.0123 0.0073 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.2527 0.2178 0.3745
Leishmania major carbamoyl-phosphate synthase, putative 0.0983 0.0826 0.0757
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.293 0.2531 0.2528
Entamoeba histolytica hypothetical protein 0.0355 0.0276 0.0312
Toxoplasma gondii carbamoylphosphate synthetase 0.0983 0.0826 0.0826
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.04 0.0315 0.0386
Loa Loa (eye worm) MH2 domain-containing protein 0.0107 0.0059 0.0061
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1101 0.0929 0.0862
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.04 0.0315 0.0241
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0355 0.0276 0.0287
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.2184 0.1878 0.1874
Loa Loa (eye worm) hypothetical protein 0.0561 0.0456 0.0475
Loa Loa (eye worm) intermediate filament protein 0.0075 0.003 0.0032
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.4347 0.3772 1
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.4347 0.3772 1
Leishmania major propionyl-coa carboxylase beta chain, putative 0.1547 0.1319 0.1257
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.04 0.0315 0.0311
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0141 0.0089 0.0092
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.04 0.0315 0.0241
Echinococcus multilocularis 0.0056 0.0014 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0916 0.0767 0.0983
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1101 0.0929 0.0925
Schistosoma mansoni intermediate filament proteins 0.0075 0.003 0.0026
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.2184 0.1878 0.3156
Trichomonas vaginalis PIKK family atypical protein kinase 0.2367 0.2038 0.347
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0355 0.0276 0.0272
Trypanosoma brucei unspecified product 0.2858 0.2468 0.2419
Leishmania major phosphatidylinositol 3-kinase, putative 0.0959 0.0805 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.1101 0.0929 0.1299
Loa Loa (eye worm) carboxyl transferase domain-containing protein 1.1014 0.961 1
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.4347 0.3772 1
Brugia malayi Protein kinase domain containing protein 0.0059 0.0016 0.0017
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.582 0.5062 0.9409
Loa Loa (eye worm) hypothetical protein 0.0402 0.0317 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.1101 0.0929 0.1299
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0039 0.0034
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1547 0.1319 0.1257
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0959 0.0805 0.107
Schistosoma mansoni hypothetical protein 0.0402 0.0317 0.0313
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.293 0.2531 0.2528
Toxoplasma gondii acetyl-CoA carboxylase ACC1 1.1413 0.9961 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0758 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.4062 0.3523 0.3665
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0355 0.0276 0.0272
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.826 0.7198 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0355 0.0276 0.0287
Schistosoma mansoni tyrosine kinase 0.0096 0.0049 0.0045
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0959 0.0805 0.0805
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0013 0.0009
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.04 0.0315 0.0311
Loa Loa (eye worm) hypothetical protein 0.005 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.2225 0.1913 0.3226
Trichomonas vaginalis PIKK family atypical protein kinase 0.1822 0.1561 0.2536
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2184 0.1878 0.1822
Plasmodium vivax hypothetical protein, conserved 0.0355 0.0276 0.0332
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.04 0.0315 0.0328
Leishmania major phosphatidylinositol 3-kinase, putative 0.1101 0.0929 0.0862
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1101 0.0929 0.0925
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2369 0.204 0.1986
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0355 0.0276 0.0272
Leishmania major mitochondrial DNA polymerase beta 0.027 0.0202 0.0126
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.04 0.0315 0.0386
Toxoplasma gondii pyruvate carboxylase 0.4347 0.3772 0.3785
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.1547 0.1319 0.1316
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.4347 0.3772 0.3739
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.04 0.0315 0.0817
Schistosoma mansoni lamin 0.0075 0.003 0.0026
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1829 0.1567 0.2539
Echinococcus multilocularis serine protein kinase ATM 0.0698 0.0576 0.0572
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0355 0.0276 0.0201
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.4347 0.3772 0.6127
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0343 0.0265 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.1661 0.142 0.2261
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1547 0.1319 0.1257
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.04 0.0315 0.0803
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.1547 0.1319 0.3431
Trichomonas vaginalis PIKK family atypical protein kinase 0.2367 0.2038 0.347
Loa Loa (eye worm) phosphatidylinositol 3 0.293 0.2531 0.2633
Trichomonas vaginalis PIKK family atypical protein kinase 0.2367 0.2038 0.347
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.04 0.0315 0.0241
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0959 0.0805 0.1317
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0983 0.0826 0.0822
Loa Loa (eye worm) phosphatidylinositol kinase 0.0355 0.0276 0.0287
Loa Loa (eye worm) hypothetical protein 0.0084 0.0039 0.004
Echinococcus multilocularis Zinc finger, PHD finger 0.0959 0.0805 0.0801
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0959 0.0805 0.1056
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0983 0.0826 0.1334
Loa Loa (eye worm) hypothetical protein 0.0141 0.0089 0.0092
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.293 0.2531 0.4108
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0959 0.0805 0.0801
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.1547 0.1319 0.3431
Trypanosoma brucei acetyl-CoA carboxylase 1.1413 0.9961 1
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0983 0.0826 0.2108
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0355 0.0276 0.0272
Brugia malayi Probable ClpP-like protease 0.0084 0.0039 0.004
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.2184 0.1878 0.3156
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0959 0.0805 0.1317
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0959 0.0805 0.0801
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.4347 0.3772 0.377
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.04 0.0315 0.074
Echinococcus multilocularis epidermal growth factor receptor 0.0098 0.0051 0.0046
Loa Loa (eye worm) phosphatidylinositol 3 0.0355 0.0276 0.0287
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.04 0.0315 0.0386
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0402 0.0317 0.0313
Schistosoma mansoni aspartate carbamoyltransferase 0.0983 0.0826 0.0822
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.4347 0.3772 0.6127
Trichomonas vaginalis PIKK family atypical protein kinase 0.1806 0.1546 0.2508
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0355 0.0276 0.044
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0983 0.0826 0.0757
Trichomonas vaginalis PIKK family atypical protein kinase 0.1822 0.1561 0.2536
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.04 0.0315 0.0241
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0141 0.0089 0.0092
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.293 0.2531 0.2633
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0355 0.0276 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.293 0.2531 0.4435
Brugia malayi latrophilin 2 splice variant baaae 0.0097 0.005 0.0052
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.1547 0.1319 0.3431
Mycobacterium leprae conserved hypothetical protein 0.0355 0.0276 0.0699
Echinococcus granulosus lamin 0.0075 0.003 0.0026
Schistosoma mansoni tyrosine kinase 0.0096 0.0049 0.0045
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.6176 0.5373 0.8731
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0959 0.0805 0.0805
Loa Loa (eye worm) phosphatidylinositol 3 0.1829 0.1567 0.163
Trichomonas vaginalis PIKK family atypical protein kinase 0.1661 0.142 0.2261
Brugia malayi Latrophilin receptor protein 2 0.0045 0.0004 0.0004
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1547 0.1319 0.2137
Mycobacterium ulcerans pyruvate carboxylase 0.4347 0.3772 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0355 0.0276 0.0272
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.04 0.0315 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0698 0.0576 0.0609
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.04 0.0315 0.0817
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.1547 0.1319 0.3431
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.04 0.0315 0.0503
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0355 0.0276 0.0287
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0959 0.0805 0.0736
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.1946 0.167 0.5857
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0355 0.0276 0.0287
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0355 0.0276 0.0332
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.1547 0.1319 0.3475
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.6176 0.5373 0.8731
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0355 0.0276 0.0332
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.04 0.0315 0.0803
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 1.1458 1 1
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.04 0.0315 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0758 0.0628 0.0711
Trichomonas vaginalis PIKK family atypical protein kinase 0.1664 0.1422 0.2264
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.04 0.0315 0.074
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0355 0.0276 0.0332
Echinococcus multilocularis lamin 0.0075 0.003 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0085 0.0081
Schistosoma mansoni tyrosine kinase 0.0059 0.0016 0.0012
Echinococcus multilocularis insulin receptor 0.0059 0.0016 0.0012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0142 0.009 0.0203
Brugia malayi Calcitonin receptor-like protein seb-1 0.0141 0.0089 0.0092
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0039 0.0034
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0698 0.0576 0.0929
Trichomonas vaginalis PIKK family atypical protein kinase 0.2225 0.1913 0.3226
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 1.1458 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0698 0.0576 0.0609
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.293 0.2531 0.2483
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.293 0.2531 0.2483
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0076 0.0072
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.4297 0.3728 0.6779
Onchocerca volvulus 0.0075 0.003 0.0815
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.1547 0.1319 0.3431
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0698 0.0576 0.0929
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0959 0.0805 0.13
Leishmania major hypothetical protein, conserved 0.0355 0.0276 0.0201
Trypanosoma cruzi target of rapamycin kinase 3 0.2369 0.204 0.3309
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0199 0.014 0.0336
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.04 0.0315 0.0817
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.6176 0.5373 1
Mycobacterium ulcerans hypothetical protein 0.0142 0.009 0.0137
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.04 0.0315 0.074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.0126 0.0131
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.5283 0.4592 0.4778
Schistosoma mansoni tyrosine kinase 0.0096 0.0049 0.0045
Loa Loa (eye worm) transcription factor SMAD2 0.0107 0.0059 0.0061
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0355 0.0276 0.0272
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0698 0.0576 0.0505
Leishmania major hypothetical protein, unknown function 0.0355 0.0276 0.0201
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0355 0.0276 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0402 0.0317 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.1101 0.0929 0.1299
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.04 0.0315 0.0503
Onchocerca volvulus 0.0075 0.003 0.0815
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.04 0.0315 0.0241
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0039 0.0034
Schistosoma mansoni lamin 0.0075 0.003 0.0026
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.1547 0.1319 0.3431
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.826 0.7198 1
Loa Loa (eye worm) hypothetical protein 0.0758 0.0628 0.0654
Trichomonas vaginalis PIKK family atypical protein kinase 0.1661 0.142 0.2261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.0276 0.0021
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.6176 0.5373 1
Entamoeba histolytica acetyl-coA carboxylase, putative 0.1946 0.167 0.2961
Loa Loa (eye worm) hypothetical protein 0.0355 0.0276 0.0287
Brugia malayi Intermediate filament tail domain containing protein 0.0075 0.003 0.0032
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0355 0.0276 0.044
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.4347 0.3772 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0355 0.0276 0.0332
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.293 0.2531 0.2528
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.04 0.0315 0.0503
Brugia malayi MH2 domain containing protein 0.0107 0.0059 0.0061
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.04 0.0315 0.0803
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.2837 0.245 0.4444
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.2184 0.1878 0.3045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0168 0.0112 0.0108
Onchocerca volvulus 0.0167 0.0111 0.3828
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.4347 0.3772 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0402 0.0317 0.0313
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.293 0.2531 0.2483
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.4347 0.3772 0.377
Brugia malayi Carboxyl transferase domain containing protein 1.1014 0.961 1
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.04 0.0315 0.074
Echinococcus granulosus lamin dm0 0.0075 0.003 0.0026
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.04 0.0315 0.0313
Echinococcus granulosus serine protein kinase ATM 0.0698 0.0576 0.0572
Loa Loa (eye worm) phosphatidylinositol 3 0.0355 0.0276 0.0287
Echinococcus granulosus tumor protein p63 0.034 0.0263 0.0259
Echinococcus granulosus acetyl coenzyme A carboxylase 1 1.1413 0.9961 0.9961
Trichomonas vaginalis PIKK family atypical protein kinase 0.2225 0.1913 0.3226
Plasmodium vivax hypothetical protein 0.0355 0.0276 0.0332
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1101 0.0929 0.0862
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1101 0.0929 0.0966
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0959 0.0805 0.0837
Echinococcus granulosus Biotin lipoyl attachment 0.04 0.0315 0.0311
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.1547 0.1319 0.3431
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0045 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0075 0.003 0.0032
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0355 0.0276 0.044
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0959 0.0805 0.0801
Mycobacterium tuberculosis Conserved hypothetical protein 0.0355 0.0276 0.0699
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.1547 0.1319 0.3475
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.2184 0.1878 0.3356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0698 0.0576 0.0609
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0355 0.0276 0.0272
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.158 0.1349 0.4509
Onchocerca volvulus 0.0123 0.0073 0.2397
Loa Loa (eye worm) hypothetical protein 0.2113 0.1816 0.1889
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0698 0.0576 0.06
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.04 0.0315 0.0386
Echinococcus granulosus insulin receptor 0.0059 0.0016 0.0012
Schistosoma mansoni transcription factor LCR-F1 0.0168 0.0112 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.2225 0.1913 0.3226
Trichomonas vaginalis PIKK family atypical protein kinase 0.1806 0.1546 0.2508
Schistosoma mansoni tyrosine kinase 0.0059 0.0016 0.0012
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.04 0.0315 0.0503
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.1547 0.1319 0.1316
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0059 0.0016 0.0012
Onchocerca volvulus 0.0355 0.0276 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2369 0.204 0.1986
Chlamydia trachomatis biotin carboxylase 0.3948 0.3422 1
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0983 0.0826 0.1099
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0059 0.0016 0.0012
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.3072 0.2655 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0355 0.0276 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.1964 0.1685 0.278
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.04 0.0315 0.0817
Schistosoma mansoni tyrosine kinase 0.0181 0.0124 0.0119
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0013 0.0009
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0959 0.0805 0.0736
Entamoeba histolytica hypothetical protein 0.495 0.43 0.7961
Echinococcus multilocularis epidermal growth factor receptor 0.0181 0.0124 0.0119
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.04 0.0315 0.0503
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0039 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.2225 0.1913 0.3226
Echinococcus multilocularis microtubule associated protein 2 0.385 0.3337 0.3334
Toxoplasma gondii FATC domain-containing protein 0.0698 0.0576 0.0576
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.027 0.0202 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.1101 0.0929 0.1299
Leishmania major phosphatidylinositol 4-kinase, putative 0.0355 0.0276 0.0201
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0983 0.0826 0.1334
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.04 0.0315 0.0386
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.04 0.0315 0.0313
Loa Loa (eye worm) hypothetical protein 0.0343 0.0265 0.0276
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.04 0.0315 0.0311
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.4347 0.3772 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0959 0.0805 0.1056
Brugia malayi Furin-like cysteine rich region family protein 0.0181 0.0124 0.0129
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0959 0.0805 0.0837
Trypanosoma brucei mitochondrial DNA polymerase beta 0.027 0.0202 0.0126
Leishmania major phosphatidylinositol kinase related protein, putative 0.0355 0.0276 0.0201
Loa Loa (eye worm) hypothetical protein 0.0045 0.0004 0.0004
Schistosoma mansoni fkbp-rapamycin associated protein 0.0698 0.0576 0.0572
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0098 0.0051 0.0046
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1101 0.0929 0.1502
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0959 0.0805 0.0801
Leishmania major carboxylase, putative 0.4347 0.3772 0.3739
Loa Loa (eye worm) phosphatidylinositol 3 1.0233 0.8927 0.9289
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.6176 0.5373 1
Toxoplasma gondii acetyl-coA carboxylase ACC2 1.1413 0.9961 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0698 0.0576 0.06
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1547 0.1319 0.2137
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.1547 0.1319 0.1322
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.293 0.2531 0.4598
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.04 0.0315 0.0328
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.04 0.0315 0.0311
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.04 0.0315 0.0803
Plasmodium falciparum carbamoyl phosphate synthetase 0.0983 0.0826 0.1099
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.6176 0.5373 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0039 0.0036
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.4347 0.3772 0.377
Treponema pallidum pyruvate carboxylase subunit B 0.04 0.0315 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0355 0.0276 0.0332
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1101 0.0929 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.293 0.2531 0.4435
Loa Loa (eye worm) TK/INSR protein kinase 0.0059 0.0016 0.0017
Schistosoma mansoni hypothetical protein 0.0168 0.0112 0.0108
Echinococcus granulosus microtubule associated protein 2 0.385 0.3337 0.3334
Trichomonas vaginalis PIKK family atypical protein kinase 0.2024 0.1737 0.2882
Loa Loa (eye worm) hypothetical protein 0.04 0.0315 0.0328
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.2184 0.1878 0.3156
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0355 0.0276 0.0021
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0355 0.0276 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.2225 0.1913 0.3226
Loa Loa (eye worm) phosphatidylinositol 3 0.0355 0.0276 0.0287
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.293 0.2531 0.2483
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0355 0.0276 0.0201
Loa Loa (eye worm) TK/EGFR protein kinase 0.0181 0.0124 0.0129
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0355 0.0276 0.0312
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0959 0.0805 0.13
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1321 0.1122 0.1057
Trichomonas vaginalis PIKK family atypical protein kinase 0.1664 0.1422 0.2264
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0355 0.0276 0.044
Loa Loa (eye worm) hypothetical protein 0.04 0.0315 0.0328
Brugia malayi hypothetical protein 0.0123 0.0073 0.0076
Echinococcus granulosus epidermal growth factor receptor 0.0181 0.0124 0.0119
Entamoeba histolytica protein kinase rad3, putative 0.0698 0.0576 0.0883
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.293 0.2531 0.4598
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.1547 0.1319 0.3785
Loa Loa (eye worm) latrophilin receptor protein 2 0.0045 0.0004 0.0004
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.04 0.0315 0.0311
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0076 0.0072
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.1547 0.1319 0.3475
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0355 0.0276 0.0272
Brugia malayi FAT domain containing protein 0.0402 0.0317 0.033
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0959 0.0805 0.0801
Schistosoma mansoni pyruvate carboxylase 0.4347 0.3772 0.377
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1101 0.0929 0.0925
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0355 0.0276 0.044
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.04 0.0315 0.0803
Entamoeba histolytica hypothetical protein 0.0355 0.0276 0.0312
Echinococcus multilocularis lamin dm0 0.0075 0.003 0.0026
Schistosoma mansoni tyrosine kinase 0.0098 0.0051 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.1822 0.1561 0.2536
Loa Loa (eye worm) hypothetical protein 0.04 0.0315 0.0328
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.4297 0.3728 0.6779
Trichomonas vaginalis PIKK family atypical protein kinase 0.1664 0.1422 0.2264
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0168 0.0112 0.0108
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.027 0.0202 0.0319
Echinococcus multilocularis Biotin lipoyl attachment 0.04 0.0315 0.0311
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.4347 0.3772 1
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.1547 0.1319 0.3475
Leishmania major phosphatidylinositol kinase, putative 0.0355 0.0276 0.0201

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.7 uM Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting ChEMBL. 22229669
IC50 (binding) > 10 uM Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting ChEMBL. 22229669
Inhibition (functional) = 0 % Antiproliferative activity against human PC3 cells at 10 uM after 72 hrs by MTS assay ChEMBL. 22229669

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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