Detailed information for compound 1644915

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.241 | Formula: C20H12Cl2N4O
  • H donors: 1 H acceptors: 3 LogP: 5.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc(cc(c1)Cl)Oc1cc(ccc1Cl)Cc1n[nH]c2c1cccn2
  • InChi: 1S/C20H12Cl2N4O/c21-14-6-13(11-23)7-15(10-14)27-19-9-12(3-4-17(19)22)8-18-16-2-1-5-24-20(16)26-25-18/h1-7,9-10H,8H2,(H,24,25,26)
  • InChiKey: UMHXETHRMTWBPR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0022 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0108 0.0108
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Echinococcus granulosus transcription factor eb 0.0096 0.034 0.034
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0916 0.377 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0067 0.0067
Brugia malayi MAP kinase sur-1 0.0055 0.0167 0.0173
Echinococcus multilocularis RUN 0.0018 0.0011 0.0011
Trypanosoma cruzi cruzipain precursor, putative 0.0057 0.0175 0.0284
Onchocerca volvulus 0.0018 0.0011 0.011
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0326 0.1301 0.2905
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0072 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0437 0.1137
Loa Loa (eye worm) hypothetical protein 0.0032 0.0072 0.0075
Loa Loa (eye worm) hypothetical protein 0.004 0.0104 0.0108
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0084 0.029 0.0746
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0167 0.0167
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.2406 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0167 0.0167
Schistosoma mansoni pyruvate carboxylase 0.0916 0.377 0.377
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0207 0.0804 0.2085
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0167 0.0271
Schistosoma mansoni DNA polymerase eta 0.004 0.0104 0.0104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0022 0.0135
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0033 0.0075 0.0751
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0033 0.0075 0.0075
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1741 0.7219 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0167 0.0271
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0084 0.029 0.0402
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.0175 0.0284
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0084 0.029 0.029
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0084 0.029 0.029
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0084 0.029 0.029
Plasmodium vivax SET domain protein, putative 0.0032 0.0072 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Schistosoma mansoni loxhd1 0.0018 0.0011 0.0011
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0326 0.1301 0.3434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0096 0.0338 0.035
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0084 0.029 0.0281
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0033 0.0075 0.0075
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0084 0.029 0.0746
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0033 0.0075 0.0075
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0033 0.0075 0.0075
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0916 0.377 0.377
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0167 0.1663
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.2406 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0437 0.1137
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0084 0.029 0.029
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0916 0.377 0.377
Leishmania major DNA polymerase eta, putative 0.004 0.0104 0.0104
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0916 0.377 0.377
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0075 0.0751
Echinococcus granulosus dna polymerase eta 0.004 0.0104 0.0104
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0104 0.0108
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0084 0.029 0.0301
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0084 0.029 0.0746
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.001 0.001
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0326 0.1301 0.3434
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0084 0.029 0.0715
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0326 0.1301 0.3434
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.0437 0.1137
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1741 0.7219 1
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0916 0.377 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0022 0.0034
Schistosoma mansoni acetyl-CoA carboxylase 0.2406 1 1
Treponema pallidum pyruvate carboxylase subunit B 0.0084 0.029 1
Schistosoma mansoni lipoxygenase 0.0105 0.0377 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0108 0.0108
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0084 0.029 0.047
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0167 0.0173
Echinococcus multilocularis transcription factor eb 0.0096 0.034 0.034
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0022 0.0031
Plasmodium vivax multidomain scavenger receptor, putative 0.0018 0.0011 0.0015
Toxoplasma gondii exonuclease III APE 0.002 0.0022 0.0022
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0084 0.029 0.047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0108 0.0108
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.0011 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.001 0.0015
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0326 0.1301 0.3434
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0916 0.377 0.6114
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0084 0.029 0.029
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0084 0.029 0.0402
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0326 0.1301 0.2905
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0326 0.1301 0.1301
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0437 0.0437
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0084 0.029 0.029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0108 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0011 0.0011
Plasmodium falciparum carbamoyl phosphate synthetase 0.0207 0.0804 0.1114
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0326 0.1301 0.211
Brugia malayi Pre-SET motif family protein 0.0224 0.0874 0.0906
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0084 0.029 0.029
Echinococcus multilocularis microtubule associated protein 2 0.0615 0.2509 0.2509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0108 0.0108
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0084 0.029 0.047
Trypanosoma cruzi acetyl-CoA carboxylase 0.149 0.6167 1
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0084 0.029 0.0281
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.001 0.001
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0084 0.029 0.029
Trypanosoma brucei unspecified product 0.0602 0.2457 0.245
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0052 0.0155 0.0251
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.0175 0.0284
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0072 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0167 0.1663
Toxoplasma gondii carbamoylphosphate synthetase 0.0207 0.0804 0.0804
Leishmania major cathepsin L-like protease 0.0057 0.0175 0.0175
Leishmania major acetyl-CoA carboxylase, putative 0.2406 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0022 0.0077
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0916 0.377 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0022 0.0031
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0326 0.1301 0.1301
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0326 0.1301 0.1301
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0084 0.029 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0207 0.0804 0.0804
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0084 0.029 0.0402
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0916 0.377 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0084 0.029 0.029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.0036
Mycobacterium ulcerans hypothetical protein 0.0084 0.029 0.0746
Trypanosoma cruzi major cysteine proteinase, putative 0.0045 0.0124 0.0202
Brugia malayi hypothetical protein 0.0135 0.0501 0.0519
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0084 0.029 0.029
Mycobacterium ulcerans pyruvate carboxylase 0.0916 0.377 1
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0084 0.029 0.029
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0033 0.0075 0.0751
Echinococcus granulosus ubiquitin specific protease 41 0.0033 0.0075 0.0075
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0105 0.0377 0.0377
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0055 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0326 0.1301 0.2905
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0167 0.0158
Loa Loa (eye worm) hypothetical protein 0.0084 0.029 0.0301
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0084 0.029 0.0715
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0084 0.029 0.029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.0437 0.1137
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0075 0.0066
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0075 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0072 0.0072
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0167 0.0957
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0017 0.001 0.0095
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0084 0.029 0.047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Leishmania major carbamoyl-phosphate synthase, putative 0.0207 0.0804 0.0804
Schistosoma mansoni microtubule-associated protein tau 0.0615 0.2509 0.2509
Leishmania major DNA polymerase kappa, putative 0.0017 0.001 0.001
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0326 0.1301 0.1293
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.001 0.001
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0084 0.029 0.0402
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0033 0.0075 0.0401
Echinococcus granulosus Biotin lipoyl attachment 0.0084 0.029 0.029
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0916 0.377 0.6114
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0326 0.1301 0.3233
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0022 0.0022
Onchocerca volvulus 0.0032 0.0072 0.0717
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.001 0.001
Brugia malayi Pre-SET motif family protein 0.0032 0.0072 0.0075
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.001 0.001
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0022 0.0222
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.0011 0.0011
Schistosoma mansoni aspartate carbamoyltransferase 0.0207 0.0804 0.0804
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0326 0.1301 0.211
Loa Loa (eye worm) hypothetical protein 0.0096 0.0338 0.035
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0207 0.0804 0.0804
Chlamydia trachomatis biotin carboxylase 0.0832 0.3418 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0501 0.0519
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0207 0.0804 0.2112
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0108 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.001 0.0015
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0084 0.029 0.0281
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0207 0.0804 0.1304
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0916 0.377 0.377
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0167 0.1663
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0167 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0072 0.0072
Leishmania major carboxylase, putative 0.0916 0.377 0.377
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0084 0.029 0.029
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.0437 0.0437
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0084 0.029 0.0301
Loa Loa (eye worm) doublecortin family protein 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0326 0.1301 0.3434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0108 0.0112
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0022 0.0023
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0916 0.377 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0017 0.001 0.0095
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0326 0.1301 0.1301
Schistosoma mansoni lipoxygenase 0.0073 0.0245 0.0245
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0167 0.0271
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0104 0.0169
Loa Loa (eye worm) hypothetical protein 0.0084 0.029 0.0301
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0072 0.0072
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0033 0.0075 0.0075
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0167 0.0167
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0326 0.1301 0.1301
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0916 0.377 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0108 0.0112
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0084 0.029 0.029
Echinococcus multilocularis dna polymerase eta 0.004 0.0104 0.0104
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.001 0.001
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0084 0.029 0.047
Leishmania major DNA polymerase eta, putative 0.0028 0.0055 0.0055
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0033 0.0075 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0108 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.0437 0.0437
Entamoeba histolytica acetyl-coA carboxylase, putative 0.041 0.1654 1
Echinococcus granulosus RUN 0.0018 0.0011 0.0011
Schistosoma mansoni polycystin 1-related 0.0018 0.0011 0.0011
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0326 0.1301 0.3434
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0033 0.0075 0.0078
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0084 0.029 0.0301
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.001 0.0015
Plasmodium falciparum LCCL domain-containing protein 0.0018 0.0011 0.0015
Trypanosoma brucei acetyl-CoA carboxylase 0.2406 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.001 0.0058
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0022
Echinococcus multilocularis Biotin lipoyl attachment 0.0084 0.029 0.029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0072 0.0072
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0916 0.377 0.377
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0033 0.0075 0.0075
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0084 0.029 0.0746
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0022 0.0023
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0084 0.029 0.029
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0326 0.1301 0.211
Onchocerca volvulus 0.0255 0.1003 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0167 0.0167
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0096 0.034 0.0352
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0084 0.029 0.029
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0022
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0916 0.377 0.3764
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.0874 0.0906
Onchocerca volvulus 0.0135 0.0501 0.4988
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.0057 0.0175 0.0175
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.0437 0.0437
Brugia malayi Doublecortin family protein 0.0018 0.0011 0.0011
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0084 0.029 0.047
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0033 0.0075 0.0456
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0011
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0326 0.1301 0.3434
Trypanosoma cruzi DNA polymerase eta, putative 0.0028 0.0055 0.0089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.001 0.0015
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.0075 0.0122
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0326 0.1301 0.1301
Schistosoma mansoni rab6-interacting 0.0018 0.0011 0.0011
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0084 0.029 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0175 0.0166
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0916 0.377 0.3764
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0207 0.0804 0.1114
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0167 0.1663
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0872 0.3586 0.3586
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0207 0.0804 0.0795
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0167 0.0167
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.0175 0.0284
Trypanosoma brucei protein kinase, putative 0.0055 0.0167 0.0158
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.2322 0.9648 1
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0207 0.0804 0.1304
Trichomonas vaginalis set domain proteins, putative 0.0255 0.1003 1
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0084 0.029 0.0746
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0072 0.0072
Brugia malayi Carboxyl transferase domain containing protein 0.2322 0.9648 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.0437 0.0437
Echinococcus multilocularis ubiquitin specific protease 41 0.0033 0.0075 0.0075
Toxoplasma gondii pyruvate carboxylase 0.0916 0.377 0.377
Echinococcus granulosus microtubule associated protein 2 0.0615 0.2509 0.2509
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0916 0.377 1
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0326 0.1301 0.3434
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0167 0.0271
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0022 0.0222
Echinococcus multilocularis dna polymerase kappa 0.0017 0.001 0.001
Schistosoma mansoni rab6-interacting 0.0018 0.0011 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.0437 0.0437
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0167 0.0167
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0072 0.0072
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0104 0.0095
Loa Loa (eye worm) hypothetical protein 0.0084 0.029 0.0301
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.041 0.1654 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.001 0.001
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0326 0.1301 0.3412
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0105 0.0377 0.0377
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0084 0.029 0.047
Leishmania major cathepsin L-like protease 0.0057 0.0175 0.0175
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0022 0.0034
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0022 0.0022
Onchocerca volvulus 0.0018 0.0011 0.011
Echinococcus granulosus dna polymerase kappa 0.0017 0.001 0.001
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0084 0.029 0.0402
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0078
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0022 0.0022
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.2406 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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