Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 22.2 % | Cytotoxicity against human HepG2 cells at 20 to 25 uM after 48 hrs by MTT assay | ChEMBL. | 22440626 |
MIC (functional) | = 0.25 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar dilution method | ChEMBL. | 22440626 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.