Detailed information for compound 1645122

Basic information

Technical information
  • TDR Targets ID: 1645122
  • Name: 2,6-dioxoadamantane-1,3,5,7-tetracarboxylic a cid
  • MW: 340.239 | Formula: C14H12O10
  • H donors: 4 H acceptors: 10 LogP: -0.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C12CC3(CC(C2=O)(CC(C1)(C3=O)C(=O)O)C(=O)O)C(=O)O
  • InChi: 1S/C14H12O10/c15-5-11(7(17)18)1-12(8(19)20)3-14(5,10(23)24)4-13(2-11,6(12)16)9(21)22/h1-4H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
  • InChiKey: CWNMLUDMKYTMQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,6-diketoadamantane-1,3,5,7-tetracarboxylic acid
  • 40460-17-1
  • NCI117489
  • NCGC00014190
  • NSC-117489
  • NSC117489
  • NCIStruc2_001186
  • NCI60_000419
  • NCIStruc1_001384
  • 2,6-dioxo-1,3,5,7-adamantanetetracarboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0058 0.0051 0.0151
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) GABA receptor subunit 0.0085 0.0246 0.0815
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0456 0.2898 0.2891
Brugia malayi MH2 domain containing protein 0.0259 0.1491 0.5126
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0817 0.5578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0492 0.3422
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0158 0.0769 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0328 0.2147
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0158 0.0766 0.2615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0272 0.1714
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0085 0.0246 0.0815
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0191 0.1008 0.6956
Schistosoma mansoni microtubule-associated protein tau 0.1449 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.007 0.0137 0.0474
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.007 0.0137 0.0619
Schistosoma mansoni tar DNA-binding protein 0.0416 0.261 0.2602
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.0814 0.278
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0456 0.2898 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0334 0.2197
Echinococcus multilocularis glycine receptor subunit beta 0.0158 0.0766 0.0756
Onchocerca volvulus 0.0456 0.2898 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Loa Loa (eye worm) ACC-1 protein 0.0158 0.0766 0.2615
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0086 0.0255 0.1586
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0058 0.0051 0.0151
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0073 0.0159 0.0513
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0078 0.0199 0.0816
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.0085 0.0246 0.0815
Echinococcus multilocularis nAChR subunit 0.0085 0.0246 0.0236
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0439 0.2779 0.2771
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0158 0.0766 0.0756
Schistosoma mansoni acetylcholine receptor-related 0.0073 0.0159 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0492 0.3422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0492 0.3422
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0019 0.0008
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0328 0.2147
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0158 0.0766 0.2615
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0456 0.2898 1
Schistosoma mansoni nAChR subunit 0.0158 0.0766 0.0756
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.0456 0.2898 1
Loa Loa (eye worm) transcription factor SMAD2 0.0259 0.1491 0.5126
Brugia malayi hypothetical protein 0.0073 0.0159 0.0513
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0218 0.0207
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0246 0.0815
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Echinococcus granulosus glycine receptor subunit beta 0.0158 0.0766 0.0756
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0246 0.0236
Loa Loa (eye worm) hypothetical protein 0.0164 0.0814 0.278
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.1875 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0238 0.1342 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0201 0.1077 0.3692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0548 0.3854
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0158 0.0769 0.3941
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0073 0.0159 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0158 0.0769 0.5568
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Giardia lamblia GTOR 0.0158 0.0769 1
Echinococcus multilocularis glycine receptor subunit beta 0.0158 0.0766 0.0756
Brugia malayi Probable ClpP-like protease 0.0081 0.0218 0.0718
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0158 0.0766 0.2616
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0158 0.0766 0.0756
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0255 0.0846
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0158 0.0766 0.0756
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0086 0.0255 0.1586
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0158 0.0766 0.0756
Brugia malayi RNA binding protein 0.0416 0.261 0.9002
Schistosoma mansoni hypothetical protein 0.0112 0.0442 0.0432
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0442 0.1493
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0073 0.0159 0.0513
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0218 0.5
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0218 0.5
Loa Loa (eye worm) LGC-31 protein 0.0158 0.0766 0.2615
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0255 0.008
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0238 0.1342 0.7121
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0158 0.0766 0.0756
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.0051 0.0137
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0158 0.0769 0.0759
Loa Loa (eye worm) hypothetical protein 0.0085 0.0246 0.0815
Onchocerca volvulus 0.0107 0.0405 0.0897
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0439 0.2779 0.2771
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0158 0.0769 0.2627
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0218 0.5
Schistosoma mansoni neurotransmitter gated ion channel 0.0073 0.0159 0.0148
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.0814 0.278
Loa Loa (eye worm) ACC-1 protein 0.0158 0.0766 0.2615
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0222 0.1223 0.8921
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0073 0.0159 0.0513
Loa Loa (eye worm) hypothetical protein 0.0456 0.2898 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0073 0.0159 0.0148
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.1875 1
Schistosoma mansoni nAChR subunit 0.0158 0.0766 0.0756
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0158 0.0769 0.3941
Entamoeba histolytica hypothetical protein 0.0191 0.1008 0.6956
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0073 0.0159 0.0513
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0058 0.0051 0.004
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0086 0.0255 0.1257
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0456 0.2898 0.2891
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0456 0.2898 0.2891
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0158 0.0766 0.0756
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0456 0.2898 0.2891
Loa Loa (eye worm) hypothetical protein 0.0107 0.0405 0.1364
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.1875 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0272 0.1714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0271 0.1707
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0167 0.083 0.604
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0158 0.0766 0.2615
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0218 0.4434
Onchocerca volvulus 0.0158 0.0766 0.2216
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.0405 0.0394
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Onchocerca volvulus 0.0085 0.0246 0.0319
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.0137 0.0437
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Onchocerca volvulus 0.0085 0.0246 0.0319
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0158 0.0766 0.0756
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0085 0.0246 0.0815
Loa Loa (eye worm) RNA binding protein 0.0416 0.261 0.9002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0051 0.0137
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0158 0.0766 0.2615
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.1449 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0246 0.0815
Brugia malayi Cation transporter family protein 0.0158 0.0766 0.2615
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0073 0.0159 0.0513
Loa Loa (eye worm) hypothetical protein 0.0085 0.0246 0.0815
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0158 0.0766 0.0756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0548 0.3854
Loa Loa (eye worm) phosphatidylinositol 3 0.0393 0.2446 0.8432
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0158 0.0766 0.0756
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0073 0.0159 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0271 0.1707
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0158 0.0769 0.5568
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0456 0.2898 0.2891
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.012 0.0497 0.5984
Echinococcus multilocularis nAChR subunit 0.0158 0.0766 0.0756
Schistosoma mansoni nAChR subunit 0.0158 0.0766 0.0756
Echinococcus granulosus nAChR subunit 0.0085 0.0246 0.0236
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0238 0.1342 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0158 0.0766 0.2615
Schistosoma mansoni neurotransmitter gated ion channel 0.0073 0.0159 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0272 0.1714
Onchocerca volvulus 0.0456 0.2898 1
Loa Loa (eye worm) hypothetical protein 0.0456 0.2898 1
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0073 0.0159 0.0513
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0238 0.1342 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0492 0.3422
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0456 0.2898 0.2891
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0167 0.083 0.604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0272 0.1714
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0158 0.0766 0.0756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0158 0.0769 0.5568
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0218 0.0207
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0158 0.0766 0.2615
Loa Loa (eye worm) MH2 domain-containing protein 0.0259 0.1491 0.5126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0271 0.1707
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0086 0.0255 0.1586
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.1342 0.4608
Brugia malayi hypothetical protein 0.0073 0.0159 0.0513
Brugia malayi TAR-binding protein 0.0416 0.261 0.9002
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2616
Brugia malayi hypothetical protein 0.0073 0.0159 0.0513
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0238 0.1342 0.7121
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0158 0.0766 0.2615
Schistosoma mansoni tar DNA-binding protein 0.0416 0.261 0.2602
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0086 0.0255 0.1122
Echinococcus multilocularis tumor protein p63 0.0731 0.4868 0.4862
Loa Loa (eye worm) hypothetical protein 0.0085 0.0246 0.0815
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0019 0.0008
Echinococcus granulosus glycine receptor subunit beta 0.0158 0.0766 0.0756
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0158 0.0769 0.4776
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0073 0.0159 0.0148
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.1875 1
Mycobacterium ulcerans hypothetical protein 0.0165 0.0817 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0073 0.0159 0.0513
Echinococcus granulosus glycine receptor subunit alpha 1 0.0158 0.0766 0.0756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.039 0.2629
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0218 0.5
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0158 0.0766 0.0756
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0158 0.0766 0.2615
Loa Loa (eye worm) acetylcholine receptor protein 0.0073 0.0159 0.0513
Schistosoma mansoni tar DNA-binding protein 0.0416 0.261 0.2602
Schistosoma mansoni neurotransmitter gated ion channel 0.0085 0.0246 0.0236
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0218 0.5
Schistosoma mansoni nAChR subunit 0.0158 0.0766 0.0756
Loa Loa (eye worm) hypothetical protein 0.0383 0.2379 0.82
Onchocerca volvulus 0.0166 0.0824 0.2425
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0697 0.3546
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.008 0.0215 0.0705
Schistosoma mansoni nAChR subunit 0.0158 0.0766 0.0756
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0158 0.0766 0.0756
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0127 0.0549 0.2732
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0158 0.0766 0.2615
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0158 0.0766 0.0756
Brugia malayi hypothetical protein 0.0073 0.0159 0.0513
Schistosoma mansoni nAChR subunit 0.0073 0.0159 0.0148
Loa Loa (eye worm) phosphatidylinositol 3 0.0158 0.0769 0.2627
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0158 0.0769 0.4776
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.0085 0.0246 0.0815
Echinococcus granulosus glycine receptor subunit alpha 1 0.0158 0.0766 0.0756
Onchocerca volvulus Putative nachr subunit 0.0456 0.2898 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.0112 0.0442 0.1493
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0238 0.1342 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0334 0.2197
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0456 0.2898 0.2891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0492 0.3422
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0158 0.0766 0.0756
Schistosoma mansoni nAChR subunit 0.0158 0.0766 0.0756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0413 0.281
Brugia malayi RNA recognition motif domain containing protein 0.0416 0.261 0.9002
Brugia malayi Cation transporter family protein 0.0456 0.2898 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0246 0.0815
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0439 0.2779 0.2771
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0158 0.0766 0.0756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0548 0.3854
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.0814 0.278
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0697 0.3643
Echinococcus granulosus tumor protein p63 0.0731 0.4868 0.4862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0136 0.0611 0.4343
Onchocerca volvulus 0.0158 0.0766 0.2216
Echinococcus granulosus nAChR subunit 0.0158 0.0766 0.0756
Trypanosoma cruzi target of rapamycin kinase 3 0.0127 0.0549 0.2842
Schistosoma mansoni acetylcholine receptor subunit beta 0.0073 0.0159 0.0148
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0158 0.0766 0.0756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0548 0.3854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0492 0.3422
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0058 0.0051 0.004
Echinococcus granulosus tar DNA binding protein 0.0416 0.261 0.2602
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0158 0.0769 0.4032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0158 0.0766 0.2615
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0158 0.0769 0.3941
Schistosoma mansoni nAChR subunit 0.0073 0.0159 0.0148
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0073 0.0159 0.0148
Loa Loa (eye worm) hypothetical protein 0.0166 0.0824 0.2814
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0158 0.0766 0.0756
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Loa Loa (eye worm) TAR-binding protein 0.0416 0.261 0.9002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0158 0.0766 0.2615
Schistosoma mansoni tar DNA-binding protein 0.0416 0.261 0.2602
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0255 0.0245
Loa Loa (eye worm) hypothetical protein 0.0158 0.0766 0.2615
Loa Loa (eye worm) hypothetical protein 0.0085 0.0246 0.0815
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Brugia malayi hypothetical protein 0.0166 0.0824 0.2814
Schistosoma mansoni nAChR subunit 0.0158 0.0766 0.0756
Brugia malayi excitatory GABA receptor EXP-1A 0.0158 0.0766 0.2615
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0697 0.3546
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0058 0.0051 0.004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0158 0.0769 0.3941
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0218 0.5
Schistosoma mansoni tar DNA-binding protein 0.0416 0.261 0.2602
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0127 0.0549 0.2732
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0158 0.0766 0.2615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0548 0.3854
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0416 0.261 0.9002
Toxoplasma gondii target of rapamycin (TOR), putative 0.0119 0.0492 1
Brugia malayi hypothetical protein 0.0073 0.0159 0.0513
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0085 0.0246 0.0236
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0456 0.2898 0.2891
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0218 0.4434
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0218 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0218 0.0718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0334 0.2197
Echinococcus multilocularis microtubule associated protein 2 0.1449 1 1
Brugia malayi Cation transporter family protein 0.0158 0.0766 0.2615
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0158 0.0769 0.0759
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0218 0.0207
Echinococcus granulosus glycine receptor subunit alpha 1 0.0158 0.0766 0.0756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0492 0.3422
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0158 0.0769 0.4032
Loa Loa (eye worm) hypothetical protein 0.0073 0.0159 0.0513
Loa Loa (eye worm) hypothetical protein 0.0085 0.0246 0.0815
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0255 0.008
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0073 0.0159 0.0513
Onchocerca volvulus 0.0456 0.2898 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0433 0.1704
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0158 0.0766 0.2615
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0158 0.0766 0.0756
Onchocerca volvulus 0.0158 0.0766 0.2216
Echinococcus multilocularis tar DNA binding protein 0.0416 0.261 0.2602

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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