Detailed information for compound 1645260

Basic information

Technical information
  • TDR Targets ID: 1645260
  • Name: 4-[(3,4-dioxonaphthalen-1-yl)amino]-N-(1,3-th iazol-2-yl)benzenesulfonamide
  • MW: 411.454 | Formula: C19H13N3O4S2
  • H donors: 2 H acceptors: 5 LogP: 2.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=C(Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)c2c(C1=O)cccc2
  • InChi: 1S/C19H13N3O4S2/c23-17-11-16(14-3-1-2-4-15(14)18(17)24)21-12-5-7-13(8-6-12)28(25,26)22-19-20-9-10-27-19/h1-11,21H,(H,20,22)
  • InChiKey: ZVYPGYFZNKUQNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(3,4-dioxo-1-naphthyl)amino]-N-thiazol-2-yl-benzenesulfonamide
  • 4-[(3,4-dioxo-1-naphthyl)amino]-N-(2-thiazolyl)benzenesulfonamide
  • 4-[(3,4-diketo-1-naphthyl)amino]-N-thiazol-2-yl-benzenesulfonamide
  • 4-[(3,4-Dioxo-3,4-dihydronaphthalen-1-yl)amino]-N-1,3-thiazol-2-ylbenzenesulfonamide
  • AIDS-029390
  • NSC648616
  • NCI60_016897
  • AIDS029390

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0245 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0048 0.0042 0.0472
Loa Loa (eye worm) hypothetical protein 0.0227 0.0541 0.7071
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0048 0.0042 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0227 0.0541 0.0527
Echinococcus granulosus cysteine protease 0.0121 0.0245 0.3147
Entamoeba histolytica cysteine proteinase 1, putative 0.0121 0.0245 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.0763 0.0748
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0048 0.0042 0.0027
Onchocerca volvulus Cathepsin F homolog 0.0227 0.0541 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0121 0.0245 0.0203
Trypanosoma cruzi cruzipain precursor, putative 0.0273 0.0669 0.8696
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0227 0.0541 0.7071
Leishmania major cathepsin L-like protease 0.0273 0.0669 1
Trypanosoma cruzi cysteine peptidase, putative 0.0273 0.0669 0.8696
Onchocerca volvulus 0.0227 0.0541 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0042 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0042 0.0068
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0227 0.0541 0.7071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0245 0.0393
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0121 0.0245 0.0229
Loa Loa (eye worm) fibroinase 0.0227 0.0541 0.7071
Echinococcus granulosus cathepsin b 0.0306 0.0763 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0128 0.0265 0.0426
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0072 0.0109 0.1359
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0042 0.0068
Schistosoma mansoni cathepsin F (C01 family) 0.0227 0.0541 0.0527
Brugia malayi cathepsin Z-like cysteine proteinase 0.0048 0.0042 0.0472
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0227 0.0541 0.0501
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0121 0.0245 0.2808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0245 0.0393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0541 0.087
Giardia lamblia Dipeptidyl-peptidase I precursor 0.14 0.3821 0.3794
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.0763 0.0748
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0541 0.087
Entamoeba histolytica cysteine protease, putative 0.0227 0.0541 1
Onchocerca volvulus Cathepsin L homolog 0.0227 0.0541 1
Plasmodium vivax vivapain-1 0.0121 0.0245 0.0203
Schistosoma mansoni cathepsin s 0.0072 0.0109 0.0094
Brugia malayi cathepsin L-like cysteine proteinase 0.0048 0.0042 0.0472
Brugia malayi cathepsin L precursor 0.0048 0.0042 0.0472
Brugia malayi cathepsin L-like precursor 0.0155 0.0339 0.4396
Echinococcus multilocularis cysteine protease 0.0227 0.0541 0.7071
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0109 0.0931
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0042 0.0472
Schistosoma mansoni cathepsin S (C01 family) 0.0048 0.0042 0.0027
Trypanosoma cruzi cysteine proteinase, putative 0.0121 0.0245 0.2808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0042 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0109 0.1359
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0245 0.2808
Brugia malayi cathepsin B-like cysteine proteinase 0.0306 0.0763 1
Leishmania major cathepsin L-like protease 0.0227 0.0541 0.6842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Giardia lamblia Cathepsin B precursor 0.0128 0.0265 0.0224
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0541 0.087
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0042 0.0027
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0245 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0541 0.087
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0472
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0245 0.4054
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.3611 1 1
Onchocerca volvulus Cathepsin L homolog 0.0227 0.0541 1
Entamoeba histolytica cysteine proteinase, putative 0.0155 0.0339 0.5946
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0072 0.0109 0.1359
Loa Loa (eye worm) hypothetical protein 0.0072 0.0109 0.1359
Brugia malayi Cathepsin L-like precursor 0.0155 0.0339 0.4396
Giardia lamblia Encystation-specific protease 0.14 0.3821 0.3794
Giardia lamblia Cathepsin B precursor 0.0128 0.0265 0.0224
Loa Loa (eye worm) hypothetical protein 0.0155 0.0339 0.4396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Toxoplasma gondii preprocathepsin c precursor, putative 0.3611 1 1
Brugia malayi fibroinase precursor 0.0048 0.0042 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0048 0.0042 0.0068
Toxoplasma gondii cathepsin CPC1 0.3611 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0042 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0227 0.0541 0.0501
Brugia malayi Cathepsin L-like precursor 0.0227 0.0541 0.7071
Loa Loa (eye worm) hypothetical protein 0.0306 0.0763 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.0339 0.4396
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0472
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0227 0.0541 0.7071
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0121 0.0245 0.2808
Leishmania major cathepsin L-like protease 0.0227 0.0541 0.6842
Trypanosoma brucei cysteine peptidase C (CPC) 0.0128 0.0265 0.0484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0042 0.0068
Echinococcus granulosus cathepsin L cysteine protease 0.0121 0.0245 0.3147
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0048 0.0042 0.0472
Echinococcus granulosus cathepsin l1 0.0155 0.0339 0.4396
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0541 1
Plasmodium vivax vivapain-2 0.0227 0.0541 0.0501
Echinococcus granulosus cathepsin b 0.0306 0.0763 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0042 0.0472
Echinococcus multilocularis cysteine protease 0.0227 0.0541 0.7071
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0042 0.0027
Echinococcus granulosus cathepsin L 0.0048 0.0042 0.0472
Plasmodium falciparum cysteine proteinase falcipain 3 0.0227 0.0541 0.0501
Leishmania major cathepsin L-like protease 0.0227 0.0541 0.6842
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0306 0.0763 0.0748
Schistosoma mansoni cathepsin B (C01 family) 0.0048 0.0042 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0042 0.0068
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0042 0.0472
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0121 0.0245 0.0229
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0128 0.0265 0.3093
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.0763 0.0748
Brugia malayi Cathepsin L-like precursor 0.0227 0.0541 0.7071
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Leishmania major cathepsin L-like protease 0.0273 0.0669 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.2259 0.6222 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0094 0.017 0.177
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0042 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0227 0.0541 0.087
Trypanosoma cruzi cysteine peptidase, putative 0.0273 0.0669 0.8696
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Giardia lamblia Cathepsin B precursor 0.0128 0.0265 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0472
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0042 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0048 0.0042 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0541 0.087
Loa Loa (eye worm) cysteine protease 0.0227 0.0541 0.7071
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.3611 1 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0048 0.0042 0.0472
Brugia malayi cathepsin Z-like cysteine proteinase 0.0048 0.0042 0.0472
Leishmania major cathepsin L-like protease 0.0227 0.0541 0.6842
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0121 0.0245 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0042 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0042 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0541 0.087
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0042 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Brugia malayi Papain family cysteine protease containing protein 0.0121 0.0245 0.3147
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.14 0.3821 0.3794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.3611 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0048 0.0042 0.0068
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Brugia malayi Cathepsin L-like precursor 0.0155 0.0339 0.4396
Onchocerca volvulus 0.0227 0.0541 1
Brugia malayi Papain family cysteine protease containing protein 0.0121 0.0245 0.3147
Toxoplasma gondii cathepsin CPL 0.0227 0.0541 0.0284
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0541 0.087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.14 0.3821 0.3794
Echinococcus multilocularis cathepsin L 0.0121 0.0245 0.3147
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0541 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0042 0.0472
Echinococcus multilocularis cathepsin L cysteine protease 0.0227 0.0541 0.7071
Brugia malayi Cathepsin L-like precursor 0.0227 0.0541 0.7071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0541 0.087
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0042 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0227 0.0541 0.7071
Onchocerca volvulus 0.0227 0.0541 1
Schistosoma mansoni cathepsin C 0.0048 0.0042 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0339 0.0545
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Loa Loa (eye worm) ctsf protein 0.0227 0.0541 0.7071
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Echinococcus granulosus cathepsin L 0.0121 0.0245 0.3147
Trypanosoma cruzi cysteine peptidase, putative 0.0273 0.0669 0.8696
Echinococcus multilocularis cathepsin L cysteine protease 0.0227 0.0541 0.7071
Onchocerca volvulus 0.0227 0.0541 1
Onchocerca volvulus 0.0227 0.0541 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0227 0.0541 0.7071
Giardia lamblia Dipeptidyl-peptidase I precursor 0.14 0.3821 0.3794
Schistosoma mansoni cathepsin F (C01 family) 0.0155 0.0339 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.3611 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0306 0.0763 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.0339 0.4396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0273 0.0669 1
Onchocerca volvulus 0.0227 0.0541 1
Brugia malayi Cathepsin L-like precursor 0.0227 0.0541 0.7071
Onchocerca volvulus 0.0227 0.0541 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0048 0.0042 0.0027
Leishmania major cathepsin L-like protease 0.0227 0.0541 0.6842
Brugia malayi cathepsin F-like cysteine proteinase 0.0072 0.0109 0.1359
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0048 0.0042 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0042 0.0472
Brugia malayi Cathepsin L-like cysteine proteinase 0.0155 0.0339 0.4396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0042 0.0068
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.3611 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0541 0.087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Leishmania major cathepsin L-like protease 0.0273 0.0669 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0042 0.0027
Plasmodium vivax unspecified product 0.0121 0.0245 0.0203
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0245 0.4054
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Trypanosoma cruzi cysteine protease, putative 0.0121 0.0245 0.2808
Toxoplasma gondii cathepsin CPC2 0.14 0.3821 0.3652
Entamoeba histolytica cysteine proteinase 2 0.0121 0.0245 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0042 0.0068
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.02 0.0467 0.5888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Brugia malayi Cathepsin L-like precursor 0.0072 0.0109 0.1359
Echinococcus granulosus cathepsin l1 0.0227 0.0541 0.7071
Echinococcus granulosus cathepsin l cysteine peptidase 0.0227 0.0541 0.7071
Plasmodium vivax unspecified product 0.0072 0.0109 0.0067
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Brugia malayi Cathepsin L-like precursor 0.0227 0.0541 0.7071
Leishmania major cysteine peptidase A (CPA) 0.0227 0.0541 0.6842
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0109 0.0931
Echinococcus multilocularis cathepsin b 0.0306 0.0763 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0472
Loa Loa (eye worm) hypothetical protein 0.0048 0.0042 0.0472
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0541 0.7071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087
Echinococcus multilocularis cathepsin b 0.0306 0.0763 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0128 0.0265 0.025
Plasmodium vivax vivapain-2 0.0227 0.0541 0.0501
Onchocerca volvulus 0.0155 0.0339 0.5946
Brugia malayi Cathepsin L-like precursor 0.0227 0.0541 0.7071
Loa Loa (eye worm) cathepsin B 0.0128 0.0265 0.3418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.0339 0.0545
Trypanosoma cruzi cysteine peptidase, putative 0.0227 0.0541 0.6926
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0042 0.0068
Echinococcus multilocularis cathepsin L 0.0048 0.0042 0.0472
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Loa Loa (eye worm) hypothetical protein 0.0072 0.0109 0.1359
Entamoeba histolytica cysteine protease, putative 0.0121 0.0245 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0227 0.0541 0.087
Plasmodium vivax vivapain-3 0.0121 0.0245 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0541 0.087

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.725 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.702 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.678 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.677 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.676 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.609 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.607 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.462 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.449 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.245 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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