Detailed information for compound 1645329

Basic information

Technical information
  • TDR Targets ID: 1645329
  • Name: 1-methyl-1H-indole-2,3-dione 3-[O-(2-chlorobe nzoyl)oxime]
  • MW: 314.723 | Formula: C16H11ClN2O3
  • H donors: 0 H acceptors: 2 LogP: 3.55 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1Cl)O/N=C\1/c2ccccc2N(C1=O)C
  • InChi: 1S/C16H11ClN2O3/c1-19-13-9-5-3-7-11(13)14(15(19)20)18-22-16(21)10-6-2-4-8-12(10)17/h2-9H,1H3/b18-14-
  • InChiKey: LYDYYASATHDZAB-JXAWBTAJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000684266
  • SMR000268070
  • ZINC05074022

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Muscleblind-like protein 0.0313 0.9496 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0419 0.2
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1905 0.9095
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0217
Brugia malayi nuclear receptor NHR-88 0.0022 0.029 0.0305
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1905 0.9095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.029 0.0305
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.029 0.0305
Schistosoma mansoni intermediate filament proteins 0.0057 0.1401 0.1401
Mycobacterium leprae Polyketide synthase Pks13 0.0079 0.2094 0.2567
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3198 0.9058
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.029 0.0305
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3198 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.1368 0.1441
Echinococcus granulosus FTZ F1 alpha 0.0022 0.029 0.0305
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0129 0.0136
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.2839 0.299
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0305
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0708 0.2493
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0305
Loa Loa (eye worm) hypothetical protein 0.009 0.244 0.257
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0016 0.0095 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0708 0.2213
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0708 0.2213
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0043 0.0932 0.4452
Brugia malayi RNA binding protein 0.0076 0.2005 0.2112
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0708 0.338
Loa Loa (eye worm) hypothetical protein 0.0057 0.1401 0.1476
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1905 0.9095
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.029 0.0305
Loa Loa (eye worm) hypothetical protein 0.0028 0.0458 0.0482
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3198 0.3368
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0044 0.0981 0.1129
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.029 0.0305
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.029 0.0305
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.1401 0.1476
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0419 0.0441
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3198 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0419 0.0441
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0038 0.0787 0.0905
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.2839 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.029 0.0305
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0708 0.0745
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.029 0.029
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.2839 0.888
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.7849 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.3517 0.3703
Loa Loa (eye worm) hypothetical protein 0.0027 0.0424 0.0447
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0708 0.2213
Schistosoma mansoni nuclear hormone receptor 0.0022 0.029 0.029
Schistosoma mansoni kinase 0.0058 0.1417 0.1417
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0043 0.0932 0.4452
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.029 0.0305
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0708 0.2213
Brugia malayi AMP-binding enzyme family protein 0.0057 0.1398 0.1472
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.7019 0.8931
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0051 0.121 0.1449
Plasmodium vivax glutathione reductase, putative 0.0103 0.2839 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0419 0.0404
Plasmodium falciparum glutathione reductase 0.0103 0.2839 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0056 0.1366 0.165
Schistosoma mansoni coup transcription factor 0.0022 0.029 0.029
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0419 0.2
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0708 0.2493
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3198 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.029 0.029
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0101 0.2769 0.2916
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0419 0.2
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0708 0.2213
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.7849 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2005 0.2005
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1905 0.1905
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.029 0.0305
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0708 0.0745
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0056 0.1366 0.165
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0708 0.2213
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3198 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0217
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0305
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0419 0.043
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0708 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0305
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0708 0.2213
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3198 0.3198
Mycobacterium ulcerans polyketide synthase 0.0053 0.1261 0.6023
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0079 0.2094 0.2588
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.029 0.0305
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2005 0.2112
Onchocerca volvulus 0.0057 0.1401 0.3752
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.029 0.029
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0021 0.0258 0.0224
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0708 0.2213
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0419 0.2
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.029 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.029 0.0305
Echinococcus multilocularis lamin dm0 0.0057 0.1401 0.1476
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.137 0.4127
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3198 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0053 0.1261 0.1492
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.029 0.0305
Brugia malayi hypothetical protein 0.0124 0.3517 0.3703
Entamoeba histolytica acyl-CoA synthetase, putative 0.0032 0.0589 0.0612
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0056 0.1366 0.6522
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0463 0.163
Loa Loa (eye worm) hypothetical protein 0.0313 0.9496 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.029 0.0305
Brugia malayi ecdysteroid receptor 0.0022 0.029 0.0305
Loa Loa (eye worm) hypothetical protein 0.0124 0.3517 0.3703
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.029 0.0305
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0017 0.0106 0.0028
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0708 0.2493
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0217
Echinococcus multilocularis musashi 0.0057 0.1401 0.1476
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.029 0.0305
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0053 0.1261 0.6023
Mycobacterium tuberculosis Probable thioesterase TesA 0.0044 0.0981 0.1154
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.029 0.0305
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0305
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.7019 0.8928
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0172 0.0112
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0172 0.0112
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0708 0.2213
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0034 0.067 0.2359
Mycobacterium ulcerans thioesterase TesA 0.0044 0.0981 0.4682
Mycobacterium ulcerans hypothetical protein 0.0027 0.0419 0.2
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2005 0.2005
Echinococcus multilocularis muscleblind protein 1 0.0313 0.9496 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0458 0.0482
Loa Loa (eye worm) glutathione reductase 0.0103 0.2839 0.299
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0419 0.0441
Brugia malayi MH2 domain containing protein 0.0116 0.3267 0.3441
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0708 0.338
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0555 0.0584
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2005 0.2112
Plasmodium falciparum thioredoxin reductase 0.0036 0.0708 0.2493
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.7019 0.8931
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3198 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.029 0.0305
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0708 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0708 0.2002
Brugia malayi intermediate filament protein 0.0057 0.1401 0.1476
Echinococcus granulosus intermediate filament protein 0.0057 0.1401 0.1476
Schistosoma mansoni lamin 0.0057 0.1401 0.1401
Mycobacterium ulcerans polyketide synthase MbtD 0.0016 0.0095 0.0454
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.029 0.0305
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.029 0.0305
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0053 0.1261 0.1515
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1905 0.2344
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.029 0.029
Onchocerca volvulus Fatty acid synthase homolog 0.0096 0.2613 0.733
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1905 0.2006
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3198 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.029 0.0305
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0056 0.1366 0.1627
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0053 0.1261 0.1492
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3198 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0053 0.1261 0.1515
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3198 0.3368
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.029 0.0305
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0419 0.1309
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0057 0.1398 0.1472
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2005 0.2112
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.029 0.0305
Echinococcus granulosus lamin 0.0057 0.1401 0.1476
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0708 0.2213
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2005 0.2005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0708 0.2213
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.1261 0.6023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0708 0.2213
Loa Loa (eye worm) hypothetical protein 0.0313 0.9496 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0708 0.0803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0708 1
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0708 0.2493
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.029 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0708 0.2213
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.029 0.029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.029 0.0305
Brugia malayi glutathione reductase 0.0103 0.2839 0.299
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.7849 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.2005 0.2112
Echinococcus granulosus lamin dm0 0.0057 0.1401 0.1476
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3198 1
Onchocerca volvulus 0.0027 0.0419 0.0848
Mycobacterium ulcerans polyketide synthase Pks13 0.0079 0.2094 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.029 0.0305
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0352 0.037
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0708 0.0708
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0206 0.2911
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.029 0.0305
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.029 0.029
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0035 0.0691 0.0755
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0043 0.0954 0.112
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.7849 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0057 0.14 0.4931
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0708 0.0745
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0708 0.338
Loa Loa (eye worm) hypothetical protein 0.0027 0.0424 0.0447
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0172 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.137 0.4127
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.029 0.0305
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0305
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1905 0.1905
Mycobacterium leprae Probable polyketide synthase Pks1 0.0056 0.1366 0.1627
Schistosoma mansoni lamin 0.0057 0.1401 0.1401
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0419 0.2
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0051 0.121 0.1449
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0419 0.0404
Onchocerca volvulus 0.0057 0.1398 0.374
Brugia malayi Methyltransferase-like protein 4 0.0016 0.0085 0.0089
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.2859 0.3011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0708 0.2213
Plasmodium falciparum thioredoxin reductase 0.0103 0.2839 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0053 0.1261 0.1328
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2005 0.2112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.029 0.0305
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.2839 0.3548
Echinococcus granulosus muscleblind protein 0.0313 0.9496 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0419 0.1309
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1905 0.6708
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0419 0.043
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.029 0.0467
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.7019 0.8931
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0206 0.0726
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2005 0.2005
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0079 0.2094 0.2588
Toxoplasma gondii thioredoxin reductase 0.0103 0.2839 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0419 0.0441
Mycobacterium ulcerans thioesterase 0.0044 0.0981 0.4682
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0708 0.2213
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0408 0.0429
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0708 0.2002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0305
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0419 0.0441
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0217
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.029 0.0305
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.3267 0.3441
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.3198 1
Leishmania major hypothetical protein, conserved 0.0016 0.0085 0.0265
Echinococcus granulosus tar DNA binding protein 0.0076 0.2005 0.2112
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.029 0.0305
Brugia malayi steroid hormone receptor 0.0022 0.029 0.0305
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0056 0.1366 0.1627
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.029 0.0305
Onchocerca volvulus Huntingtin homolog 0.0124 0.3517 1
Loa Loa (eye worm) intermediate filament protein 0.0057 0.1401 0.1476
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.1261 0.6023
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0458 0.0482
Mycobacterium tuberculosis Probable reductase 0.0234 0.7019 0.8931
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.029 0.0305
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1905 0.5956
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0206 0.0984
Brugia malayi TAR-binding protein 0.0076 0.2005 0.2112
Brugia malayi nuclear hormone receptor 0.0022 0.029 0.0305
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.1401 0.1476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.029 0.0305
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.1261 0.6023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.029 0.0305
Loa Loa (eye worm) fatty acid synthase 0.0052 0.1239 0.1305
Loa Loa (eye worm) hypothetical protein 0.0027 0.0419 0.0441
Onchocerca volvulus 0.01 0.2755 0.7751
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0018 0.0156 0.0092
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.029 0.0305
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0555 0.0584
Toxoplasma gondii type I fatty acid synthase, putative 0.0038 0.0776 0.2733
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0056 0.1366 0.165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0172 0.0112
Schistosoma mansoni thyroid hormone receptor 0.0022 0.029 0.029
Mycobacterium ulcerans fatty acid synthase Fas 0.0017 0.0106 0.0508
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0408 0.0429
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0708 0.2493
Giardia lamblia Kinase, PLK 0.0114 0.3198 1
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0708 0.2002
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0056 0.1366 0.6522
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0206 0.0726
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.029 0.0467
Trypanosoma brucei polo-like protein kinase 0.0114 0.3198 1
Onchocerca volvulus 0.0022 0.029 0.0467
Brugia malayi Thioredoxin reductase 0.0103 0.2839 0.299
Mycobacterium ulcerans polyketide synthase 0.0056 0.1366 0.6522
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0057 0.1398 0.1691
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0708 0.2493
Loa Loa (eye worm) hypothetical protein 0.002 0.0206 0.0217
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.029 0.0305
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1905 0.2006
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.2859 0.3011
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0419 0.2
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.3267 0.3441
Loa Loa (eye worm) hypothetical protein 0.003 0.0521 0.0548
Schistosoma mansoni methyltransferase-related 0.0016 0.0085 0.0085
Onchocerca volvulus 0.0057 0.1401 0.3752
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.029 0.0305
Mycobacterium ulcerans polyketide synthase Pks9 0.0035 0.0691 0.3299
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0035 0.0691 0.3299
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3198 0.3368
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.029 0.029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0708 0.2213
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.029 0.029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.029 0.0305
Trypanosoma brucei trypanothione reductase 0.0103 0.2839 0.888
Schistosoma mansoni thyroid hormone receptor 0.0022 0.029 0.029
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0043 0.0932 0.1067
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0053 0.1261 0.1515
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3198 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.7019 0.8931
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.003 0.0535 0.058
Plasmodium falciparum glutathione reductase 0.0036 0.0708 0.2493
Onchocerca volvulus Huntingtin homolog 0.0124 0.3517 1
Echinococcus multilocularis muscleblind protein 0.0313 0.9496 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0419 0.2
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0206 0.0156
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0419 0.1309
Leishmania major trypanothione reductase 0.0103 0.2839 0.888
Echinococcus multilocularis lamin 0.0057 0.1401 0.1476
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0305
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.029 0.0305
Treponema pallidum NADH oxidase 0.0036 0.0708 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2005 0.2005
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3198 0.3368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.029 0.0305
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0708 0.2213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.029 0.0305
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.7019 0.8931

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.6679 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Beta-Lactamase Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Texas Red Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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